DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sh and kcns3

DIOPT Version :9

Sequence 1:	NP_001303569.1	Gene:	Sh / 32780	FlyBaseID:	FBgn0003380	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	XP_031758930.1	Gene:	kcns3 / 100497261	XenbaseID:	XB-GENE-952059	Length:	490	Species:	Xenopus tropicalis

Alignment Length:	510	Identity:	165/510 - (32%)
Similarity:	261/510 - (51%)	Gaps:	104/510 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    97 ERVVINVSGLRFETQLRTLNQFPDTLLG------DPARRLRYFDPLR---NEYFFDRSRPSFDAI 152
            |.|.:||.|.:.....:||.:||.|.||      .....|...|...   .||:|||:...|..|
Frog    15 ELVKLNVGGFKQSVDQKTLLRFPHTRLGKLLNCRSEEAILELCDDYNVADKEYYFDRNPSLFRYI 79

  Fly   153 LYYYQSGGRLRRPVNVPLDVFSEEIKFYELGDQAI-----NKFRE-------------------- 192
            |.:|.: |:|.....:.:..||:||:::.:.:..|     ||::|
Frog    80 LNFYYT-GKLHVMEELCVFSFSQEIEYWGINELFIDSCCSNKYQEKKEIIAEKDWDQKSDIISLG 143

  Fly   193 ----DEGFIKEEERPLPDNEK----QRKVWLLFEYPESSQAARVVAIISVFVILLSIVIFCLETL 249
                |:..:.|.|..:.|..|    :||:|:..|.|..|.:|::.||.|:.|:|.|||..|:.::
Frog   144 SSSSDQSSVFERELEMFDTLKFGDIRRKIWIRLENPAYSLSAKLFAIASLSVVLTSIVAMCIHSM 208

  Fly   250 PEFKHYKVFNTTTNGTKIEEDEVPDITDPFF-LIETLCIIWFTFELTVRFLACPNKLNFCRDVMN 313
            ||||            |::.:: .::.||.. ::|.:||||||.||.:|.:..|::..|.::.||
Frog   209 PEFK------------KLDAND-RELEDPVLAVVEIVCIIWFTSELVIRLIVAPSQKKFWKNPMN 260

  Fly   314 VIDIIAIIPYFITLATVVAEEED--TLNLPKAPVSPQDKSSNQAMSLAILRVIRLVRVFRIFKLS 376
            :||.::|||::.||...|.:||:  ..|:.|                 :::::||:|:|||.||:
Frog   261 IIDFVSIIPFYATLVVDVNDEENEGIENMGK-----------------VVQILRLMRIFRILKLA 308

  Fly   377 RHSKGLQILGRTLKASMRELGLLIFFLFIGVVLFSSAVYFAEAGSDSSFFKSIPDGFWWAVVTMT 441
            |||.||:.||.|||.|..|:|||:.||.:|:.:||..||:.|...|.|...|||..:|||.::||
Frog   309 RHSVGLRSLGATLKHSYHEVGLLLLFLAVGISIFSVLVYYVEKDEDQSGLHSIPMCWWWATISMT 373

  Fly   442 TVGYGDMRPVGVWGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRE--------TDQEEMQSQN 498
            ||||||..||.::||:||::|.|.|:|.:|||:.:|.:.|:.:|.::        .|.|  |...
Frog   374 TVGYGDTHPVTLFGKLVGTVCIICGILVVALPITIIFNKFSKYYQKQKAIDVDGCNDDE--QKDK 436

  Fly   499 FNHVTSCPY--LPGTLGQHMKK--SSLSE-----------SSSDMMDLDDGVEST 538
            ||.:   ||  :.....:.|..  ||||.           .:|.:.:::|....|
Frog   437 FNDL---PYFNIRDIYARRMNSFISSLSSVGIIASGNDSTDASSIQEIEDAFPPT 488

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sh	NP_001303569.1	BTB_2	99..187	CDD:280393	28/96 (29%)
		BTB	99..182	CDD:197585	28/91 (31%)
		Ion_trans	274..488	CDD:278921	91/216 (42%)
		Ion_trans_2	403..479	CDD:285168	37/75 (49%)
kcns3	XP_031758930.1	BTB_POZ_KCNS3	15..122	CDD:349735	32/107 (30%)
kcns3	XP_031758930.1	Ion_trans	185..421	CDD:395416	106/265 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000074
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910