Protein Alignment Sh and kcns3

DIOPT Version :10

• Sequence 1: NP_728123.1
• Gene: Sh / 32780
• FlyBaseID: FBgn0003380
• Length: 655
• Species: Drosophila melanogaster
• Sequence 2: XP_031758930.1
• Gene: kcns3 / 100497261
• XenbaseID: XB-GENE-952059
• Length: 490
• Species: Xenopus tropicalis
• Alignment Length: 510
• Identity: 164/510 - (32%)
• Similarity: 261/510 - (51%)
• Gaps: 104/510 - (20%)

  Fly    97 ERVVINVSGLRFETQLRTLNQFPDTLLG------DPARRLRYFDPLR---NEYFFDRSRPSFDAI 152
            |.|.:||.|.:.....:||.:||.|.||      .....|...|...   .||:|||:...|..|
 Frog    15 ELVKLNVGGFKQSVDQKTLLRFPHTRLGKLLNCRSEEAILELCDDYNVADKEYYFDRNPSLFRYI 79

  Fly   153 LYYYQSGGRLRRPVNVPLDVFSEEIKFYELGDQAI-----NKFRE-------------------- 192
            |.:|.: |:|.....:.:..||:||:::.:.:..|     ||::|
 Frog    80 LNFYYT-GKLHVMEELCVFSFSQEIEYWGINELFIDSCCSNKYQEKKEIIAEKDWDQKSDIISLG 143

  Fly   193 ----DEGFIKEEERPLPDNEK----QRKVWLLFEYPESSQAARVVAIISVFVILLSIVIFCLETL 249
                |:..:.|.|..:.|..|    :||:|:..|.|..|.:|::.||.|:.|:|.|||..|:.::
 Frog   144 SSSSDQSSVFERELEMFDTLKFGDIRRKIWIRLENPAYSLSAKLFAIASLSVVLTSIVAMCIHSM 208

  Fly   250 PEFKHYKVFNTTTNGTKIEEDEVPDITDPFF-LIETLCIIWFTFELTVRFLACPNKLNFCRDVMN 313
            ||||            |::.:: .::.||.. ::|.:||||||.||.:|.:..|::..|.::.||
 Frog   209 PEFK------------KLDAND-RELEDPVLAVVEIVCIIWFTSELVIRLIVAPSQKKFWKNPMN 260

  Fly   314 VIDIIAIIPYFITLATVVAEEED--TLNLPKAPVSPQDKSSNQAMSLAILRVIRLVRVFRIFKLS 376
            :||.::|||::.||...|.:||:  ..|:.|                 :::::||:|:|||.||:
 Frog   261 IIDFVSIIPFYATLVVDVNDEENEGIENMGK-----------------VVQILRLMRIFRILKLA 308

  Fly   377 RHSKGLQILGRTLKASMRELGLLIFFLFIGVVLFSSAVYFAEAGSENSFFKSIPDAFWWAVVTMT 441
            |||.||:.||.|||.|..|:|||:.||.:|:.:||..||:.|...:.|...|||..:|||.::||
 Frog   309 RHSVGLRSLGATLKHSYHEVGLLLLFLAVGISIFSVLVYYVEKDEDQSGLHSIPMCWWWATISMT 373

  Fly   442 TVGYGDMTPVGVWGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRE--------TDQEEMQSQN 498
            ||||||..||.::||:||::|.|.|:|.:|||:.:|.:.|:.:|.::        .|.|  |...
 Frog   374 TVGYGDTHPVTLFGKLVGTVCIICGILVVALPITIIFNKFSKYYQKQKAIDVDGCNDDE--QKDK 436

  Fly   499 FNHVTSCPY--LPGTLGQHMKK--SSLSE-----------SSSDMMDLDDGVEST 538
            ||.:   ||  :.....:.|..  ||||.           .:|.:.:::|....|
 Frog   437 FNDL---PYFNIRDIYARRMNSFISSLSSVGIIASGNDSTDASSIQEIEDAFPPT 488

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sh	NP_728123.1	BTB_POZ	97..223	CDD:453885	43/167 (26%)
		Ion_trans	226..488	CDD:459842	105/264 (40%)
kcns3	XP_031758930.1	BTB_POZ_KCNS3	15..122	CDD:349735	32/107 (30%)
		Ion_trans	185..421	CDD:459842	105/265 (40%)