DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sh and kcna4

DIOPT Version :9

Sequence 1:	NP_001303569.1	Gene:	Sh / 32780	FlyBaseID:	FBgn0003380	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	XP_004913509.1	Gene:	kcna4 / 100495646	XenbaseID:	XB-GENE-492827	Length:	688	Species:	Xenopus tropicalis

Alignment Length:	545	Identity:	322/545 - (59%)
Similarity:	391/545 - (71%)	Gaps:	59/545 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 EQLEQKEEQKKIAERKLQLREQQLQRNSLDGYGSLPKLSSQDEEGGAGHGFGGGPQHFEPIPHDH 93
            |::..|||..:..::|..|.|     :..|..|||.:..|..|:|            :.|:..:.
Frog   142 EEMMLKEEVSEEEDQKFYLCE-----DDEDEAGSLHRRRSPKEDG------------YHPVYSEF 189

  Fly    94 DFCERVVINVSGLRFETQLRTLNQFPDTLLGDPARRLRYFDPLRNEYFFDRSRPSFDAILYYYQS 158
            :.|||||||||||||||||:||.|||:||||||.:|:||||||||||||||:|||||||||||||
Frog   190 ECCERVVINVSGLRFETQLKTLTQFPETLLGDPEKRMRYFDPLRNEYFFDRNRPSFDAILYYYQS 254

  Fly   159 GGRLRRPVNVPLDVFSEEIKFYELGDQAINKFREDEGFIKEEERPLPDNEKQRKVWLLFEYPESS 223
            ||||:||||||.|:||||:||||||::|:.|:||||||:||||:.||:||.:::|||||||||||
Frog   255 GGRLKRPVNVPFDIFSEEVKFYELGEEALLKYREDEGFVKEEEKQLPENEFKKQVWLLFEYPESS 319

  Fly   224 QAARVVAIISVFVILLSIVIFCLETLPEFKHYK---------------------VFNTT---TNG 264
            ..||.:||:||.|||:|||||||||||||:..|                     .:|.|   |:.
Frog   320 GPARGIAIVSVLVILISIVIFCLETLPEFRDDKDSLLSPLGMGDDGTGEDGEGGAYNATFLLTDH 384

  Fly   265 TKIEEDEVPDITDPFFLIETLCIIWFTFELTVRFLACPNKLNFCRDVMNVIDIIAIIPYFITLAT 329
            |.        ..||||::||:||:||:||..||..|||:|..|.:|:||:|||::|:||||||.|
Frog   385 TA--------FNDPFFIVETVCIVWFSFEFAVRLFACPSKPGFFKDIMNIIDIVSILPYFITLGT 441

  Fly   330 VVAE----EEDTLNLPKAPVSPQDK-SSNQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGRTL 389
            .:.:    ::..|.|......||.. ...||||.||||:|||||||||||||||||||||||.||
Frog   442 ELGQQHPPQQQHLALGTGQQLPQGTGQQQQAMSFAILRIIRLVRVFRIFKLSRHSKGLQILGHTL 506

  Fly   390 KASMRELGLLIFFLFIGVVLFSSAVYFAEAGSDSSFFKSIPDGFWWAVVTMTTVGYGDMRPVGVW 454
            :|||||||||||||||||:|||||||||||...::.|.||||.||||||||||||||||:|:.|.
Frog   507 RASMRELGLLIFFLFIGVILFSSAVYFAEADEPTTHFHSIPDAFWWAVVTMTTVGYGDMKPITVG 571

  Fly   455 GKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETDQEEMQSQNFNHVTSCPYLPGTLGQHMKKS 519
            ||||||||||||||||||||||||||||||||||||.|| |:|.....:||||||..|.:.::
Frog   572 GKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETDNEE-QTQLTQSSSSCPYLPTNLLKKLR-- 633

  Fly   520 SLSESSSDMMDLDDGVESTPGLTET 544
              |.:||.:.|..:.:|...||.|:
Frog   634 --SSTSSSLQDKSEYLEMEEGLKES 656

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sh	NP_001303569.1	BTB_2	99..187	CDD:280393	74/87 (85%)
		BTB	99..182	CDD:197585	71/82 (87%)
		Ion_trans	274..488	CDD:278921	153/218 (70%)
		Ion_trans_2	403..479	CDD:285168	62/75 (83%)
kcna4	XP_004913509.1	K_channel_TID	1..83	CDD:369607
		BTB_POZ	193..319	CDD:365784	101/125 (81%)
		Ion_trans	322..605	CDD:366146	180/290 (62%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	361	1.000	Domainoid score	I949
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	624	1.000	Inparanoid score	I853
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D307298at33208
OrthoFinder	1	1.000	-	-		FOG0000074
OrthoInspector	1	1.000	-	-		otm49432
Panther	1	1.100	-	-	O	PTHR11537
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	9.070