Protein Alignment Sh and kcna4

DIOPT Version :10

• Sequence 1: NP_728123.1
• Gene: Sh / 32780
• FlyBaseID: FBgn0003380
• Length: 655
• Species: Drosophila melanogaster
• Sequence 2: XP_004913509.1
• Gene: kcna4 / 100495646
• XenbaseID: XB-GENE-492827
• Length: 688
• Species: Xenopus tropicalis
• Alignment Length: 545
• Identity: 323/545 - (59%)
• Similarity: 390/545 - (71%)
• Gaps: 59/545 - (10%)

  Fly    29 EQLEQKEEQKKIAERKLQLREQQLQRNSLDGYGSLPKLSSQDEEGGAGHGFGGGPQHFEPIPHDH 93
            |::..|||..:..::|..|.|     :..|..|||.:..|..|:|            :.|:..:.
 Frog   142 EEMMLKEEVSEEEDQKFYLCE-----DDEDEAGSLHRRRSPKEDG------------YHPVYSEF 189

  Fly    94 DFCERVVINVSGLRFETQLRTLNQFPDTLLGDPARRLRYFDPLRNEYFFDRSRPSFDAILYYYQS 158
            :.|||||||||||||||||:||.|||:||||||.:|:||||||||||||||:|||||||||||||
 Frog   190 ECCERVVINVSGLRFETQLKTLTQFPETLLGDPEKRMRYFDPLRNEYFFDRNRPSFDAILYYYQS 254

  Fly   159 GGRLRRPVNVPLDVFSEEIKFYELGDQAINKFREDEGFIKEEERPLPDNEKQRKVWLLFEYPESS 223
            ||||:||||||.|:||||:||||||::|:.|:||||||:||||:.||:||.:::|||||||||||
 Frog   255 GGRLKRPVNVPFDIFSEEVKFYELGEEALLKYREDEGFVKEEEKQLPENEFKKQVWLLFEYPESS 319

  Fly   224 QAARVVAIISVFVILLSIVIFCLETLPEFKHYK---------------------VFNTT---TNG 264
            ..||.:||:||.|||:|||||||||||||:..|                     .:|.|   |:.
 Frog   320 GPARGIAIVSVLVILISIVIFCLETLPEFRDDKDSLLSPLGMGDDGTGEDGEGGAYNATFLLTDH 384

  Fly   265 TKIEEDEVPDITDPFFLIETLCIIWFTFELTVRFLACPNKLNFCRDVMNVIDIIAIIPYFITLAT 329
            |.        ..||||::||:||:||:||..||..|||:|..|.:|:||:|||::|:||||||.|
 Frog   385 TA--------FNDPFFIVETVCIVWFSFEFAVRLFACPSKPGFFKDIMNIIDIVSILPYFITLGT 441

  Fly   330 VVAE----EEDTLNLPKAPVSPQDK-SSNQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGRTL 389
            .:.:    ::..|.|......||.. ...||||.||||:|||||||||||||||||||||||.||
 Frog   442 ELGQQHPPQQQHLALGTGQQLPQGTGQQQQAMSFAILRIIRLVRVFRIFKLSRHSKGLQILGHTL 506

  Fly   390 KASMRELGLLIFFLFIGVVLFSSAVYFAEAGSENSFFKSIPDAFWWAVVTMTTVGYGDMTPVGVW 454
            :|||||||||||||||||:|||||||||||....:.|.|||||||||||||||||||||.|:.|.
 Frog   507 RASMRELGLLIFFLFIGVILFSSAVYFAEADEPTTHFHSIPDAFWWAVVTMTTVGYGDMKPITVG 571

  Fly   455 GKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETDQEEMQSQNFNHVTSCPYLPGTLGQHMKKS 519
            ||||||||||||||||||||||||||||||||||||.|| |:|.....:||||||..|.:.::
 Frog   572 GKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETDNEE-QTQLTQSSSSCPYLPTNLLKKLR-- 633

  Fly   520 SLSESSSDMMDLDDGVESTPGLTET 544
              |.:||.:.|..:.:|...||.|:
 Frog   634 --SSTSSSLQDKSEYLEMEEGLKES 656

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sh	NP_728123.1	BTB_POZ	97..223	CDD:453885	101/125 (81%)
		Ion_trans	226..488	CDD:459842	181/290 (62%)
kcna4	XP_004913509.1	K_channel_TID	1..83	CDD:429748
		BTB_POZ	193..319	CDD:453885	101/125 (81%)
		Ion_trans	322..605	CDD:459842	181/290 (62%)