Protein Alignment Sh and kcna6

DIOPT Version :10

• Sequence 1: NP_728123.1
• Gene: Sh / 32780
• FlyBaseID: FBgn0003380
• Length: 655
• Species: Drosophila melanogaster
• Sequence 2: XP_004912861.1
• Gene: kcna6 / 100492986
• XenbaseID: XB-GENE-1010669
• Length: 481
• Species: Xenopus tropicalis
• Alignment Length: 480
• Identity: 324/480 - (67%)
• Similarity: 369/480 - (76%)
• Gaps: 39/480 - (8%)

  Fly    62 SLPKLSSQDEEGGAGHGFGGGPQHFEPIPHDHDFCERVVINVSGLRFETQLRTLNQFPDTLLGDP 126
            :|..||:..:||            ::|.....|.|||||||:||||||||||||:|||.||||||
 Frog    12 TLVSLSALGQEG------------YDPDRATQDCCERVVINISGLRFETQLRTLSQFPQTLLGDP 64

  Fly   127 ARRLRYFDPLRNEYFFDRSRPSFDAILYYYQSGGRLRRPVNVPLDVFSEEIKFYELGDQAINKFR 191
            .:|:|:||||||||||||:||||||||||||||||||||||||:|:|.|||||||||::.|..||
 Frog    65 RKRMRFFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPVDIFLEEIKFYELGEEVIEIFR 129

  Fly   192 EDEGFIKEEERPLPDNEKQRKVWLLFEYPESSQAARVVAIISVFVILLSIVIFCLETLPEFK--- 253
            :|||||||||||||:|:.||:|||||||||||..||.:||:||.:||:|||||||||||||:
 Frog   130 DDEGFIKEEERPLPENDFQRQVWLLFEYPESSGPARGIAIVSVLIILISIVIFCLETLPEFREEA 194

  Fly   254 HYKVFNTTTNGTKIEEDEVPDITDPFFLIETLCIIWFTFELTVRFLACPNKLNFCRDVMNVIDII 318
            .........|||....:.  ..||||||.||||||||:|||.|||.|||:|..|.:::||||||:
 Frog   195 RQSGGQPAVNGTHTFTNS--PFTDPFFLTETLCIIWFSFELLVRFFACPSKPAFFKNMMNVIDIV 257

  Fly   319 AIIPYFITLATVVAEEEDTLNLPKAPVSPQDKSSNQAMSLAILRVIRLVRVFRIFKLSRHSKGLQ 383
            |||||||||.|.:||:             |..:..||||||||||||||||||||||||||||||
 Frog   258 AIIPYFITLGTELAEQ-------------QGSNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQ 309

  Fly   384 ILGRTLKASMRELGLLIFFLFIGVVLFSSAVYFAEAGSENSFFKSIPDAFWWAVVTMTTVGYGDM 448
            |||:||:|||||||||||||||||:||||||||||.....|.|.|||||||||||:|||||||||
 Frog   310 ILGKTLQASMRELGLLIFFLFIGVILFSSAVYFAETDDPESLFTSIPDAFWWAVVSMTTVGYGDM 374

  Fly   449 TPVGVWGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETDQEEMQSQNFNHVTSCPYLPGTLG 513
            .|:.:.||||||||||||||||||||||||||||||||||||.|| ||| :.||| |...|.:.|
 Frog   375 YPMTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETDHEE-QSQ-YTHVT-CGQQPSSYG 436

  Fly   514 QHMKKSSLSES--SSDMM---DLDD 533
            . :|||...:|  .||.|   :|||
 Frog   437 D-LKKSESKQSFNRSDYMESEELDD 460

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sh	NP_728123.1	BTB_POZ	97..223	CDD:453885	104/125 (83%)
		Ion_trans	226..488	CDD:459842	185/264 (70%)
kcna6	XP_004912861.1	BTB_POZ	35..161	CDD:453885	104/125 (83%)
		Ion_trans	206..414	CDD:459842	162/222 (73%)