DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sh and kcnc4

DIOPT Version :9

Sequence 1:	NP_001303569.1	Gene:	Sh / 32780	FlyBaseID:	FBgn0003380	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	XP_002933043.1	Gene:	kcnc4 / 100492941	XenbaseID:	XB-GENE-6032635	Length:	598	Species:	Xenopus tropicalis

Alignment Length:	545	Identity:	194/545 - (35%)
Similarity:	283/545 - (51%)	Gaps:	104/545 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    98 RVVINVSGLRFETQLRTLNQFPDT---LLGDP-ARRLRYFDPLRNEYFFDRSRPSFDAILYYYQS 158
            ::.|||.|.|.||...||...|.|   .|.|| .......|..|.|:||||....|..:|.||::
Frog    37 KITINVGGTRHETYKSTLRTLPGTRLAWLADPDTASNSESDSQRTEFFFDRHPGIFSYVLNYYRT 101

  Fly   159 GGRLRRPVNVPLDVFSEEIKFYEL------------------GDQAINKF---------REDEGF 196
             |:|..|.::...:|.||:.|:.:                  .::|::.|         .|::|.
Frog   102 -GKLHCPADICGPLFEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDIFENVEPEDGEEENKGS 165

  Fly   197 IKE----EERPLPDNEK------QRKVWLLFEYPESSQAARVVAIISVFVILLSIVIFCLETLPE 251
            ..|    |||  .|..:      |.|:|.|||.|.||:||||||.:|:|.||:||..|||||...
Frog   166 SPELLCIEER--TDRSRGCWKVWQPKMWALFEDPYSSRAARVVAFVSLFFILMSITTFCLETHES 228

  Fly   252 F-KHYKVFNTTTNGTKIEEDEVPDI-TDPFF-LIETLCIIWFTFELTVRFLACPNKLNFCRDVMN 313
            | ....|..|.|.|...|...|.:: |:|.. .||.:|:.|||.|..||.:.||:|:.|.::::|
Frog   229 FIVDRNVTETVTIGNMTEILVVREVETEPILTYIEGVCVFWFTLEFLVRIICCPDKVFFVKNLLN 293

  Fly   314 VIDIIAIIPYFITLATVVAEEEDTLNLPKAPVSPQDKSSNQAMS-LAILRVIRLVRVFRIFKLSR 377
            :||.:||:|:::                  .|.....||..|.. |..|||:|.||:.|||||:|
Frog   294 IIDFVAILPFYL------------------EVGLSGLSSKAARDVLGFLRVVRFVRILRIFKLTR 340

  Fly   378 HSKGLQILGRTLKASMRELGLLIFFLFIGVVLFSSAVYFAE---------AGSDSSFFKSIPDGF 433
            |..||::||.||:||..|..|||.||.:||::|::.:|:||         :||:.:.||:||.||
Frog   341 HFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGANPTDPSGSNHTHFKNIPIGF 405

  Fly   434 WWAVVTMTTVGYGDMRPVGVWGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETDQEEMQSQN 498
            |||||||||:|||||.|....|.:||:|||:|||||||:||||||:||..:|.....:::
Frog   406 WWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQK----- 465

  Fly   499 FNHVTSCPYLPGTLGQHMKKSSLSESSSDMMDLDDGVESTPGLTETHPGRSAVAPFLGAQQQQQQ 563
                     ||....:|:.|:|..:|.:.:...|:        :..:..:|...| |.|::..::
Frog   466 ---------LPKKKKKHVPKTSQMDSQTTLKSEDN--------SHRNSTQSDTCP-LAAEELTEK 512

  Fly   564 PVASSL------SMSIDKQLQHPLQ 582
            ..:.|.      ::..|:..:.|||
Frog   513 KRSDSKQNGDANAVMSDEDHEDPLQ 537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sh	NP_001303569.1	BTB_2	99..187	CDD:280393	32/109 (29%)
		BTB	99..182	CDD:197585	32/86 (37%)
		Ion_trans	274..488	CDD:278921	104/225 (46%)
		Ion_trans_2	403..479	CDD:285168	48/84 (57%)
kcnc4	XP_002933043.1	Potassium_chann	1..29	CDD:314363
		BTB_POZ	34..150	CDD:365784	33/113 (29%)
		Ion_trans	203..461	CDD:366146	127/275 (46%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910