DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sh and kcna1

DIOPT Version :9

Sequence 1:	NP_001303569.1	Gene:	Sh / 32780	FlyBaseID:	FBgn0003380	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	XP_004912857.1	Gene:	kcna1 / 100492822	XenbaseID:	XB-GENE-991584	Length:	489	Species:	Xenopus tropicalis

Alignment Length:	460	Identity:	320/460 - (69%)
Similarity:	373/460 - (81%)	Gaps:	20/460 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    81 GGPQ-HFEPIPHDHDFCERVVINVSGLRFETQLRTLNQFPDTLLGDPARRLRYFDPLRNEYFFDR 144
            |.|| .:.|...||:.||||||||:||||||||:||:|||:||||:|.:|:||||||||||||||
Frog    17 GHPQDSYHPDQDDHECCERVVINVAGLRFETQLKTLSQFPNTLLGNPKKRMRYFDPLRNEYFFDR 81

  Fly   145 SRPSFDAILYYYQSGGRLRRPVNVPLDVFSEEIKFYELGDQAINKFREDEGFIKEEERPLPDNEK 209
            :||||||||||||||||||||||||||:|||||||||||::|:.|||||||||:|||||||:.|.
Frog    82 NRPSFDAILYYYQSGGRLRRPVNVPLDMFSEEIKFYELGEEAMEKFREDEGFIREEERPLPEKEF 146

  Fly   210 QRKVWLLFEYPESSQAARVVAIISVFVILLSIVIFCLETLPEFKHYKVFN-TTTNGTKIEEDEVP 273
            ||:|||||||||||..||::||:||.|||:||||||||||||.|..::|: ...|.|...:..:
Frog   147 QRQVWLLFEYPESSGPARIIAIVSVMVILISIVIFCLETLPELKDERIFSRRVNNSTVFYKSNI- 210

  Fly   274 DITDPFFLIETLCIIWFTFELTVRFLACPNKLNFCRDVMNVIDIIAIIPYFITLATVVAEEEDTL 338
             .|||||::||||||||:|||.|||.|||:|..|.:::||.|||:|||||||||.|.:||:|
Frog   211 -FTDPFFVVETLCIIWFSFELVVRFFACPSKPEFFKNIMNFIDIVAIIPYFITLGTEMAEQE--- 271

  Fly   339 NLPKAPVSPQDKSSNQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGRTLKASMRELGLLIFFL 403
                   .||  ...||.||||||||||||||||||||||||||||||:||||||||||||||||
Frog   272 -------GPQ--KGEQATSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFL 327

  Fly   404 FIGVVLFSSAVYFAEAGSDSSFFKSIPDGFWWAVVTMTTVGYGDMRPVGVWGKIVGSLCAIAGVL 468
            ||||:|||||||||||..|.|.|.||||.||||||:|||||||||.||.:.||||||||||||||
Frog   328 FIGVILFSSAVYFAEAEEDESHFASIPDAFWWAVVSMTTVGYGDMYPVTIGGKIVGSLCAIAGVL 392

  Fly   469 TIALPVPVIVSNFNYFYHRETDQEEMQSQNFNHVTSCPYLPGTLGQHMKKSSLSESSSDMMDLDD 533
            |||||||||||||||||||||:.|| |:| ..|| |.|.|... ....::||.:.|.|:.|::::
Frog   393 TIALPVPVIVSNFNYFYHRETEGEE-QAQ-LLHV-STPNLASD-SDLSRRSSSTMSKSEYMEIEE 453

  Fly   534 GVEST 538
            .:.::
Frog   454 DLNNS 458

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sh	NP_001303569.1	BTB_2	99..187	CDD:280393	75/87 (86%)
		BTB	99..182	CDD:197585	72/82 (88%)
		Ion_trans	274..488	CDD:278921	163/213 (77%)
		Ion_trans_2	403..479	CDD:285168	63/75 (84%)
kcna1	XP_004912857.1	BTB_POZ	34..160	CDD:365784	106/125 (85%)
kcna1	XP_004912857.1	Ion_trans	163..412	CDD:366146	188/262 (72%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	361	1.000	Domainoid score	I949
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	624	1.000	Inparanoid score	I853
OMA	1	1.010	-	-		QHG48093
OrthoDB	1	1.010	-	-		D307298at33208
OrthoFinder	1	1.000	-	-		FOG0000074
OrthoInspector	1	1.000	-	-		otm49432
Panther	1	1.100	-	-	O	PTHR11537
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3654
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	11.110