Protein Alignment Sh and kcnb2

DIOPT Version :10

• Sequence 1: NP_728123.1
• Gene: Sh / 32780
• FlyBaseID: FBgn0003380
• Length: 655
• Species: Drosophila melanogaster
• Sequence 2: XP_002937117.3
• Gene: kcnb2 / 100489419
• XenbaseID: XB-GENE-989392
• Length: 901
• Species: Xenopus tropicalis
• Alignment Length: 582
• Identity: 189/582 - (32%)
• Similarity: 295/582 - (50%)
• Gaps: 112/582 - (19%)

  Fly    98 RVVINVSGLRFETQLRTLNQFPDTLLGDPARRLR-------------YFDPLRNEYFFDRSRPSF 149
            ||.|||.||..|...|||::.|.|.||    :||             .::...|||||||...:|
 Frog    36 RVKINVGGLNHEVLWRTLDRLPRTRLG----KLRDCNTHESLLEVCDDYNLNENEYFFDRHPGAF 96

  Fly   150 DAILYYYQSGGRLRRPVNVPLDVFSEEI----------------KFYELGDQAINKFREDEGFIK 198
            .:||.:|:: |:|.....:....|.:|:                ::::..:|...:.|.:...::
 Frog    97 TSILNFYRT-GKLHMMEEMCALSFGQELDYWGIDEIYLESCCQARYHQKKEQMNEELRREAETLR 160

  Fly   199 EEERPLPDN----EKQRKVWLLFEYPESSQAARVVAIISVFVILLSIVIFCLETLPEFKHYKVFN 259
            |.|....||    ||::|:|.|.|.|.||.||:::||||:..|:||.:...|.|||:.:....|.
 Frog   161 EREGEEFDNTCCPEKRKKLWDLLEKPNSSVAAKILAIISILFIVLSTIALSLNTLPDLQETDEFG 225

  Fly   260 TTTNGTKIEEDEVPDITDPFFLIETLCIIWFTFELTVRFLACPNKLNFCRDVMNVIDIIAIIPYF 324
            ...:..::..            :|.:||.|||.|..:|||:.|||..|.:..:|:||::||:||:
 Frog   226 QPNDNPQLAH------------VEAVCIAWFTMEYLLRFLSSPNKWKFFKGPLNIIDLLAILPYY 278

  Fly   325 ITLATVVAEEEDTLNLPKAPVSPQDKSSNQAMSL-AILRVIRLVRVFRIFKLSRHSKGLQILGRT 388
            :|:.                ::..:||..|..:: .::::.|::|:.||.||:|||.|||.||.|
 Frog   279 VTIF----------------LTESNKSVLQFQNVRRVVQIFRIMRILRILKLARHSTGLQSLGFT 327

  Fly   389 LKASMRELGLLIFFLFIGVVLFSSAVYFAEAGSENSFFKSIPDAFWWAVVTMTTVGYGDMTPVGV 453
            |:.|..||||||.||.:|:::|||.|:|||...:.:.|.|||.:||||.:|||||||||:.|..:
 Frog   328 LRRSYNELGLLILFLAMGIMIFSSLVFFAEKDEDATKFTSIPASFWWATITMTTVGYGDIYPKTL 392

  Fly   454 WGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETDQEEMQSQNFNHVTSCPYLPGTLGQHMKK 518
            .|||||.||.|||||.||||:|:||:||:.||..:..||:.                     :|:
 Frog   393 LGKIVGGLCCIAGVLVIALPIPIIVNNFSEFYKEQKRQEKA---------------------IKR 436

  Fly   519 SSLSE-----SSSDMMDLDDGVESTPGLTETHPGRSAVAPFLGAQQQQQQPVASSLSMSIDKQLQ 578
            ....|     .|...|:|.|....:..|.:....:||     ....:.::|..:.||.|..|..:
 Frog   437 REALERAKRNGSIVSMNLKDAFARSMELIDVVVDKSA-----DGSNKMEKPSDNHLSPSRWKWSR 496

  Fly   579 HPLQQLTQTQLYQQQQQQ------QQQQQNGFKQQQQQTQQQLQQ-------QQSH-TINAS 626
            ..|.:.:..:.:..:.|:      |:|..|.....|..:.|:|::       .||| ::|:|
 Frog   497 RTLSETSSNKSFDNKYQEVSQHDSQEQLNNASSSPQHLSAQKLEELYNEITKAQSHPSVNSS 558

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sh	NP_728123.1	BTB_POZ	97..223	CDD:453885	45/157 (29%)
		Ion_trans	226..488	CDD:459842	112/262 (43%)
kcnb2	XP_002937117.3	BTB_POZ_KCNB2	19..145	CDD:349719	32/113 (28%)
		Ion_trans	192..428	CDD:459842	112/263 (43%)
		Kv2channel	471..755	CDD:397541	20/93 (22%)