Protein Alignment Sh and kcnd1

DIOPT Version :10

• Sequence 1: NP_728123.1
• Gene: Sh / 32780
• FlyBaseID: FBgn0003380
• Length: 655
• Species: Drosophila melanogaster
• Sequence 2: XP_031747765.1
• Gene: kcnd1 / 100488387
• XenbaseID: XB-GENE-6047565
• Length: 631
• Species: Xenopus tropicalis
• Alignment Length: 596
• Identity: 182/596 - (30%)
• Similarity: 296/596 - (49%)
• Gaps: 133/596 - (22%)

  Fly    97 ERVVINVSGLRFETQLRTLNQFPDTLLGDPARRLRYFDPLRNEYFFDRSRPSFDAILYYYQSGGR 161
            |.:|:||||.:|:|...||:::||||||...:.. :|:....||||||....|..||.:|:: |:
 Frog    40 EILVVNVSGRKFQTWKNTLDRYPDTLLGSTEKDF-FFNQDTQEYFFDRDPEMFRHILNFYRT-GK 102

  Fly   162 LRRPVNVPLDVFSEEIKFYE-----LGDQAINKFR-----------EDEGFIKEEERPL-PDNEK 209
            |..|.:..:..|.||:.||.     :||..:.::|           ||.......:.|| ||:..
 Frog   103 LHYPRHECIQAFDEELSFYGIIPEIIGDCCLEEYRDRKKENLERLAEDTEAETAGDTPLPPDSTF 167

  Fly   210 QRKVWLLFEYPESSQAARVVAIISVFVILLSIVIFCLETLP---------EFKHYKVFNTTTNGT 265
            ::::|..||.|.:|..|.|...::.|.|.:|::...:||:|         |....:.:|..
 Frog   168 RQRLWRAFENPHTSTMALVFYYVTGFFIAVSVIANVVETVPCRPPAGRLKELPCGEKYNLA---- 228

  Fly   266 KIEEDEVPDITDPFFLIETLCIIWFTFELTVRFLACPNKLNFCRDVMNVIDIIAIIPYFITLATV 330
                         |..::|.|::.||||..:|..|.|::..|.|.||::||::||:|::|.|
 Frog   229 -------------FVCMDTACVLIFTFEYLMRLFAAPSRCKFMRSVMSIIDVVAIMPFYIGL--- 277

  Fly   331 VAEEEDTLNLPKAPVSPQDKSSNQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGRTLKASMRE 395
                          |.|:    |:.:|.|.: .:|:.|||||||.||||:||:|||.|||:...|
 Frog   278 --------------VMPE----NENVSGAFV-TLRVFRVFRIFKFSRHSQGLRILGYTLKSCASE 323

  Fly   396 LGLLIFFLFIGVVLFSSAVYFAEAGSENSFFKSIPDAFWWAVVTMTTVGYGDMTPVGVWGKIVGS 460
            ||.|:|.|.:.:::|::.:::||.|:..:.|.|||.|||:.:|||||:|||||.|..:.|||.||
 Frog   324 LGFLLFSLTMAIIIFATVMFYAEKGTSKTKFTSIPAAFWYTIVTMTTLGYGDMVPDTIAGKIFGS 388

  Fly   461 LCAIAGVLTIALPVPVIVSNFNYFYHRETDQEEMQSQNFNHVTSCPYLPGTLGQHMKKSSLSESS 525
            :|:::|||.||||||||||||:..||:....::.::|                |.::.:.:..:.
 Frog   389 ICSLSGVLVIALPVPVIVSNFSRIYHQNQRADKRRAQ----------------QKIRLARIRLAK 437

  Fly   526 SDMMDLDDGVESTPGL---TETH----PGRSAVAPFLGAQQQQQQPVASSLSMSIDKQLQHPLQQ 583
            |:........:.:.||   ||:|    ..|||                      .:.|..|.|..
 Frog   438 SNTTGAFLRYKESGGLEEGTESHALCVKNRSA----------------------FELQHHHLLHC 480

  Fly   584 LTQTQLYQQQQQQQQQQQNGFKQQQQQTQQQLQQQQSH-TINASAAAATSGSGSSGLTMRH---- 643
            |.:|..::            |..|...::..:.:...: |..:::.::..|.|:|....|:
 Frog   481 LEKTTCHE------------FTDQHTYSEALMTESIGYRTSRSTSVSSQQGFGTSCCPRRNKRRA 533

  Fly   644 ----NNALAVS 650
                |:.::||
 Frog   534 IRLANSTVSVS 544

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sh	NP_728123.1	BTB_POZ	97..223	CDD:453885	48/142 (34%)
		Ion_trans	226..488	CDD:459842	107/270 (40%)
kcnd1	XP_031747765.1	BTB_POZ_KCND1	6..143	CDD:349724	38/104 (37%)
		Ion_trans	184..415	CDD:459842	106/269 (39%)
		DUF3399	466..542	CDD:463381	16/109 (15%)