DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sh and kcnf1

DIOPT Version :9

Sequence 1:	NP_001303569.1	Gene:	Sh / 32780	FlyBaseID:	FBgn0003380	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	NP_001096396.1	Gene:	kcnf1 / 100124998	XenbaseID:	XB-GENE-979363	Length:	484	Species:	Xenopus tropicalis

Alignment Length:	486	Identity:	147/486 - (30%)
Similarity:	233/486 - (47%)	Gaps:	94/486 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    87 EPIPHDHDFCE---RVVINVSGLRFETQLRTLNQFPDTLLGDPARRLR--Y---------FDPLR 137
            |.:..|...|.   .:.:||.|:|.......||::|:|.|.:....:.  |         :||.:
Frog     8 EELSGDGSDCSEEVEITVNVGGIRQVLYGDVLNRYPETRLAELVNCMAGGYDAIFSLCDDYDPGK 72

  Fly   138 NEYFFDRSRPSFDAILYYYQSGGRLRRPVNVPLDVFSEEIKFYELGDQAIN---------KFRED 193
            .|::|||...:|..|:..|..|....:....|: .|..|:.|:.:....::         |..|.
Frog    73 KEFYFDRDPDAFKCIIEVYLYGEVHMKKGICPI-CFKNEMDFWRVDLDLLDDCCKSHLNEKNLEL 136

  Fly   194 EGFIKEEERPLPD----------NEKQRKVWLLFEYPESSQAARVVAIISVFVILLSIVIFCLET 248
            |...|..:..|.|          ...|:.:|...|.||||..||:.||:|...||:|..:.|:.|
Frog   137 EEIAKRVQTILDDLGGDTSESKWKRFQKCLWKFMEKPESSFPARITAILSFLFILISSTVMCIGT 201

  Fly   249 LPEFKHYKVFNTTTNGTKIEEDEVPDITDPFFLIETLCIIWFTFELTVRFLACPNKLNFCRDVMN 313
            :||.:...:     .|..:|...:..       |||:||.|||.|..:|.::.||:|:|....||
Frog   202 IPEMQVEDL-----QGNHVEHPTLDS-------IETVCIGWFTLEYLLRLISSPNRLHFALSFMN 254

  Fly   314 VIDIIAIIPYFITL------ATVVAEEEDTLNLPKAPVSPQDKSSNQAMSLAILRVIRLVRVFRI 372
            :||::||:|:::::      ||::.    ..|:.:|                 ::.:|::|:.||
Frog   255 IIDVLAILPFYVSIILTNLGATIMG----LTNVQQA-----------------IQALRIMRIARI 298

  Fly   373 FKLSRHSKGLQILGRTLKASMRELGLLIFFLFIGVVLFSSAVYFAEAGSDSSFFKSIPDGFWWAV 437
            |||:|||.|||.|...||:|.:|||||:.:|.:|:.:||:..|..|.....:.|||||..||||:
Frog   299 FKLARHSSGLQTLTYALKSSFKELGLLLMYLAVGIFVFSALGYTMEQSHPDTLFKSIPQSFWWAI 363

  Fly   438 VTMTTVGYGDMRPVGVWGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHR----------ETDQE 492
            :|||||||||:.|....||:..:...:.||:.||||:..|::||..:|::          |.:..
Frog   364 ITMTTVGYGDIYPKTTLGKLNAATSFLCGVIAIALPIHPIINNFVKYYNKQRVLETATKHELELM 428

  Fly   493 EMQSQNFNHVTSCPYLPGTLGQHMKKSSLSE 523
            |:.|..           |.||.:.....|||
Frog   429 ELHSNG-----------GYLGTNGSSKELSE 448

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sh	NP_001303569.1	BTB_2	99..187	CDD:280393	24/98 (24%)
		BTB	99..182	CDD:197585	24/93 (26%)
		Ion_trans	274..488	CDD:278921	84/229 (37%)
		Ion_trans_2	403..479	CDD:285168	34/75 (45%)
kcnf1	NP_001096396.1	BTB	23..124	CDD:321966	24/101 (24%)
kcnf1	NP_001096396.1	Ion_trans	179..415	CDD:306908	98/268 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000074
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910