DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sh and kcnc2

DIOPT Version :9

Sequence 1:	NP_001303569.1	Gene:	Sh / 32780	FlyBaseID:	FBgn0003380	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	NP_001082998.2	Gene:	kcnc2 / 100037377	ZFINID:	ZDB-GENE-070410-118	Length:	597	Species:	Danio rerio

Alignment Length:	632	Identity:	205/632 - (32%)
Similarity:	289/632 - (45%)	Gaps:	152/632 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    97 ERVVINVSGLRFETQLRTLNQFPDT---LLGDPARRLRYFDPLR------------NEYFFDRSR 146
            |||::||.|.|.||...||...|.|   ||...:......|.|:            |||||||..
Zfish     8 ERVILNVGGTRHETYRSTLKTLPGTRLALLASESDLELVLDQLQQVPGFIEYSARSNEYFFDRHP 72

  Fly   147 PSFDAILYYYQSGGRLRRPVNVPLDVFSEEIKFYEL------------------GDQAINKF--- 190
            ..|..:|.||:: |:|..|.:|...:|.||:.|:.:                  .::|::.|
Zfish    73 GVFAYVLNYYRT-GKLHCPADVCGPLFEEELSFWGIDETDVEPCCWMTYRQHRDAEEALDVFEMN 136

  Fly   191 ---REDEGFIKE---EERPLPDNEKQR------KVWLLFEYPESSQAARVVAIISVFVILLSIVI 243
               .||:.:.|.   |:....|....|      .:|.||:.|.||:|||.:|..|:|.|::||..
Zfish   137 VDTEEDDEYGKRLGIEDVVSADGTVSRWRRWQPVIWNLFDDPYSSRAARFIAFASLFFIMVSITT 201

  Fly   244 FCLETLPEFKHYKVFNTTTNGT-KIEEDEVPDI-------TDP-FFLIETLCIIWFTFELTVRFL 299
            |||||      ::.|||..|.| .:..:.:.||       ||| ...:|.:|::|||||..||..
Zfish   202 FCLET------HEAFNTIINKTDPLRNETLTDISQQYEIETDPALTYVEGVCVLWFTFEFLVRIT 260

  Fly   300 ACPNKLNFCRDVMNVIDIIAIIPYFITLATVVAEEEDTLNLPKAPVSPQDKSSNQAMS-LAILRV 363
            ..|:||.|.:.|:|:||.:||:|:::                  .|.....||..|.. |..|||
Zfish   261 FSPDKLEFIKSVLNIIDFVAILPFYL------------------EVGLSGLSSKAAKDVLGFLRV 307

  Fly   364 IRLVRVFRIFKLSRHSKGLQILGRTLKASMRELGLLIFFLFIGVVLFSSAVYFAE---------A 419
            :|.||:.|||||:||..||::||.||:||..|..|||.||.:||::|::.:|:||         .
Zfish   308 VRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGASPNDPT 372

  Fly   420 GSDSSFFKSIPDGFWWAVVTMTTVGYGDMRPVGVWGKIVGSLCAIAGVLTIALPVPVIVSNFNYF 484
            .|..:.||:||.|||||||||||:|||||.|....|.:||:|||:|||||||:||||||:||..:
Zfish   373 ASHHTMFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMVVGALCALAGVLTIAMPVPVIVNNFGMY 437

  Fly   485 YHRETDQEEMQSQNFNHV-----TSCPYLPGTLGQHMKKSSLSESSSDMMDLDDGVESTP----- 539
            |.....::::..:...|:     |..|....|                  ||.....||.
Zfish   438 YSLAMAKQKLPKKRKKHIPQAVQTGSPLYCRT------------------DLSTACNSTQGELCI 484

  Fly   540 ----GLTETHPGRSAVAPFLGAQQQQQQPVASSLSMSIDKQLQHPLQQLTQTQLYQQQQQQQQQQ 600
                ||.....|.:.|  .|.|.........|.:|||                    .:::...:
Zfish   485 GQSRGLERHRSGETLV--HLHAVLSADCSAGSDISMS--------------------PEERMPMR 527

  Fly   601 QNGFKQQQQQTQQQ--LQQQQSHTINASAAAATSGSGSSGLTMRHNN 645
            .:..::|...|:..  |.....:|..|.||.......|..|    ||
Zfish   528 HSSVREQDHHTEGTCFLLAPSDYTCTADAAIRKGSEKSRSL----NN 570

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sh	NP_001303569.1	BTB_2	99..187	CDD:280393	34/120 (28%)
		BTB	99..182	CDD:197585	34/97 (35%)
		Ion_trans	274..488	CDD:278921	107/231 (46%)
		Ion_trans_2	403..479	CDD:285168	47/84 (56%)
kcnc2	NP_001082998.2	amino terminal assembly domain	1..185		51/177 (29%)
		BTB	10..123	CDD:197585	34/113 (30%)
		BTB_2	10..115	CDD:280393	34/105 (32%)
		S1-S6 membrane domain	186..504		136/361 (38%)
		Ion_trans	235..442	CDD:278921	105/224 (47%)
		Ion_trans_2	<385..432	CDD:285168	35/46 (76%)
		post S6 proximal carboxyl terminal domain	505..560		11/74 (15%)
		distal carboxyl terminus	561..597		4/14 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810