Protein Alignment Sh and LOC100004160

DIOPT Version :10

• Sequence 1: NP_728123.1
• Gene: Sh / 32780
• FlyBaseID: FBgn0003380
• Length: 655
• Species: Drosophila melanogaster
• Sequence 2: XP_021330984.1
• Gene: LOC100004160 / 100004160
• -ID: -
• Length: 545
• Species: Danio rerio
• Alignment Length: 537
• Identity: 313/537 - (58%)
• Similarity: 383/537 - (71%)
• Gaps: 45/537 - (8%)

  Fly     9 GLGEDRQHRKK-QQQQQQHQKEQLEQKEEQKKIAERKLQLREQQLQRNSLDGYGSLPKLSSQDEE 72
            |.||..|::.. ...:..|.||...:..:|.......:.........|::|.|.  |.|..:|
Zfish    18 GDGESYQNQNSLDHPRLVHNKEVFPRSPQQSSWKMNDMNSTIMGSTENTVDYYS--PHLFEED-- 78

  Fly    73 GGAGHGFGGGPQHFEPIPHDHDFCERVVINVSGLRFETQLRTLNQFPDTLLGDPARRLRYFDPLR 137
                         ...:..||:..|||:||::||||||||.|||||||||||||.:|::||||||
Zfish    79 -------------ILDMDLDHENNERVLINIAGLRFETQLGTLNQFPDTLLGDPDKRIKYFDPLR 130

  Fly   138 NEYFFDRSRPSFDAILYYYQSGGRLRRPVNVPLDVFSEEIKFYELGDQAINKFREDEGFIKEEER 202
            |||||||:|||||.|||:|||||::||||||.:|||::||:||:||::|:::||||||||||||:
Zfish   131 NEYFFDRNRPSFDGILYFYQSGGKIRRPVNVSIDVFADEIRFYQLGEEAMDRFREDEGFIKEEEK 195

  Fly   203 PLPDNEKQRKVWLLFEYPESSQAARVVAIISVFVILLSIVIFCLETLPEFKHYK---VFNTTTNG 264
            |||.||.|::|||:|||||||..||.:||:||.||.:||:.|||||||||:..:   |.:...||
Zfish   196 PLPQNEFQKQVWLIFEYPESSSPARGIAIVSVIVITISIITFCLETLPEFRDERELPVTSRAVNG 260

  Fly   265 TKIEEDEVPDI--TDPFFLIETLCIIWFTFELTVRFLACPNKLNFCRDVMNVIDIIAIIPYFITL 327
            |:    |.|.:  |||||:|||.|:|||||||.|||.|||:|..|.:.:||:|||::|:|||||:
Zfish   261 TQ----ERPSLTFTDPFFIIETTCVIWFTFELFVRFFACPSKSEFSKTIMNIIDIMSIMPYFITV 321

  Fly   328 ATVVAEEEDTLNLPKAPVSPQDKSSNQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGRTLKAS 392
            .|.:||::          ..:..:..|||||||||||||||||||||||||||||||||:|||||
Zfish   322 GTELAEQQ----------GQEHNNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKAS 376

  Fly   393 MRELGLLIFFLFIGVVLFSSAVYFAEAGSENSFFKSIPDAFWWAVVTMTTVGYGDMTPVGVWGKI 457
            |||||||||||||||:||||||:||||....|.|.|||||||||||||||||||||.||.|.|||
Zfish   377 MRELGLLIFFLFIGVILFSSAVFFAEADEPESHFSSIPDAFWWAVVTMTTVGYGDMRPVTVGGKI 441

  Fly   458 VGSLCAIAGVLTIALPVPVIVSNFNYFYHRETDQEEMQSQNFNHVTSCPYLPGTLGQHMKKSSLS 522
            ||||||||||||||||||||||||||||||||||::...::.      |...||..|......|.
Zfish   442 VGSLCAIAGVLTIALPVPVIVSNFNYFYHRETDQDQASLRDE------PNNGGTSNQSDDLHGLR 500

  Fly   523 ESSSDMMDLDDGVESTP 539
            :||.|:...:|  .:||
Zfish   501 KSSKDVERNED--SNTP 515

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sh	NP_728123.1	BTB_POZ	97..223	CDD:453885	95/125 (76%)
		Ion_trans	226..488	CDD:459842	184/266 (69%)
LOC100004160	XP_021330984.1	BTB_POZ	90..216	CDD:453885	95/125 (76%)
		Ion_trans	265..472	CDD:459842	160/216 (74%)