DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sh and kcnd1

DIOPT Version :9

Sequence 1:	NP_001303569.1	Gene:	Sh / 32780	FlyBaseID:	FBgn0003380	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	NP_001119942.1	Gene:	kcnd1 / 100001681	ZFINID:	ZDB-GENE-081105-40	Length:	632	Species:	Danio rerio

Alignment Length:	433	Identity:	167/433 - (38%)
Similarity:	250/433 - (57%)	Gaps:	61/433 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    88 PIPHDHDFCERVVINVSGLRFETQLRTLNQFPDTLLGDPARRLRYFDPLRNEYFFDRSRPSFDAI 152
            ||...:...|.:.:|||||||:|...||:::||||||...:...|.:..: ||||||....|..|
Zfish    31 PIDKKNRNDEILFVNVSGLRFQTWKNTLDRYPDTLLGSSEKEFFYNEDTQ-EYFFDRDPEMFRHI 94

  Fly   153 LYYYQSGGRLRRPVNVPLDVFSEEIKFYE-----LGDQAINKFREDEGFIKE-EER--------- 202
            |.:|:: |||..|....:..|.||:.||.     :||..:.::|:.:   || :||
Zfish    95 LNFYRT-GRLHYPRQECIQAFDEELAFYGIVPDIIGDCCMEEYRDRK---KENQERLAVDTEAEM 155

  Fly   203 ----PLPDNEKQR-KVWLLFEYPESSQAARVVAIISVFVILLSIVIFCLETLPEFKHYKVFNTTT 262
                |||.:...| ::|..||.|.:|..|.|...::.|.|.:|::...:||:|           .
Zfish   156 ATDTPLPPHSTHRERLWRAFENPHTSTMALVFYYVTGFFIAVSVIANVVETVP-----------C 209

  Fly   263 NGTKIEEDEVP---DITDPFFLIETLCIIWFTFELTVRFLACPNKLNFCRDVMNVIDIIAIIPYF 324
            ...|..:.::|   ..:..||.::|.|::.||||..:|..|.|::..|.|.||:|||::||:||:
Zfish   210 RPLKGSKKDLPCGEKYSLAFFCMDTACVLIFTFEYLMRLFAAPSRCKFMRSVMSVIDVVAIMPYY 274

  Fly   325 ITLATVVAEEEDTLNLPKAPVSPQDKSSNQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGRTL 389
            |.|  |:.|.||                   :|.|.: .:|:.|||||||.||||:||:|||.||
Zfish   275 IGL--VMPENED-------------------VSGAFV-TLRVFRVFRIFKFSRHSQGLRILGYTL 317

  Fly   390 KASMRELGLLIFFLFIGVVLFSSAVYFAEAGSDSSFFKSIPDGFWWAVVTMTTVGYGDMRPVGVW 454
            |:...|||.|:|.|.:.:::|::.:::||.|:..:.|.|||..||:.:|||||:|||||.|..:.
Zfish   318 KSCASELGFLLFSLTMAIIIFATVMFYAEKGTKGTNFTSIPASFWYTIVTMTTLGYGDMVPNTIA 382

  Fly   455 GKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETDQEEMQSQ 497
            |||.||:|:::|||.||||||||||||:..||:....::|::|
Zfish   383 GKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQRADKMRAQ 425

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sh	NP_001303569.1	BTB_2	99..187	CDD:280393	38/92 (41%)
		BTB	99..182	CDD:197585	36/87 (41%)
		Ion_trans	274..488	CDD:278921	100/213 (47%)
		Ion_trans_2	403..479	CDD:285168	39/75 (52%)
kcnd1	NP_001119942.1	Shal-type	3..28	CDD:288455
		BTB_2	42..131	CDD:280393	37/90 (41%)
		BTB	44..132	CDD:197585	38/89 (43%)
		Ion_trans	217..415	CDD:278921	100/219 (46%)
		Ion_trans_2	331..411	CDD:285168	43/79 (54%)
		DUF3399	445..542	CDD:288712
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.810