DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG6847 and LPL

DIOPT Version :10

Sequence 1:NP_573259.2 Gene:CG6847 / 32778 FlyBaseID:FBgn0030884 Length:1000 Species:Drosophila melanogaster
Sequence 2:NP_000228.1 Gene:LPL / 4023 HGNCID:6677 Length:475 Species:Homo sapiens


Alignment Length:388 Identity:119/388 - (30%)
Similarity:185/388 - (47%) Gaps:58/388 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly   194 VIVHGFG-SACPHVWIYEMKTALMAVE-DCIVICVDWENGATFPNYVRAAANTRLVGKQLAMLLR 256
            :::||:. :.....|:.::..||...| |..||.|||.:.|. .:|..:|..|:|||:.:|..:.
Human    77 MVIHGWTVTGMYESWVPKLVAALYKREPDSNVIVVDWLSRAQ-EHYPVSAGYTKLVGQDVARFIN 140

  Fly   257 NLQQHKGLDLMRTHVIGFSLGAHVSGFAGA-ELPGLSRITGLDPAGPLFEAQHPKVRLDSSDAEF 320
            .:::.....|...|::|:|||||.:|.||: ....::||||||||||.||......||...||:|
Human   141 WMEEEFNYPLDNVHLLGYSLGAHAAGIAGSLTNKKVNRITGLDPAGPNFEYAEAPSRLSPDDADF 205

  Fly   321 VDVIHSNGENLILGGLGSWQPMGHVDYYPNGGRVQTGCSNLFVGAVTDFIWSAQAAEDEEGRSLC 385
            |||:|:.........:|..:|:||||.|||||..|.||:   :|.....| :.:...|.:....|
Human   206 VDVLHTFTRGSPGRSIGIQKPVGHVDIYPNGGTFQPGCN---IGEAIRVI-AERGLGDVDQLVKC 266

  Fly   386 NHRRAYKFFIDSVA----PRCLFPAFPCGNYDDFLKGRCFPCAQDDEDLAEGVPRCGNMGYYAD- 445
            :|.|:...||||:.    |.   .|:.|.:.:.|.||.|..|.::         ||.|:||..: 
Human   267 SHERSIHLFIDSLLNEENPS---KAYRCSSKEAFEKGLCLSCRKN---------RCNNLGYEINK 319

  Fly   446 -RSTGRGQLYLLTREEEPFCAHQFQLQIFNSFNDLPLRTIGRLEAILEGDGGLNETFEIS----- 504
             |:....::||.||.:.|:....:|::|..|..:....|              |:.||||     
Human   320 VRAKRSSKMYLKTRSQMPYKVFHYQVKIHFSGTESETHT--------------NQAFEISLYGTV 370

  Fly   505 -EKDDAEFFAGDI-----VSKIIVPHPALGFPTTLSLHYK-----SYSGWLSKGLPHWDIDKV 556
             |.::..|...::     .|.:|.....:|....|.|.:|     |:|.|.|.  |.:.|.|:
Human   371 AESENIPFTLPEVSTNKTYSFLIYTEVDIGELLMLKLKWKSDSYFSWSDWWSS--PGFAIQKI 431

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG6847NP_573259.2 Pancreat_lipase_like 185..459 CDD:238363 93/273 (34%)
LPLNP_000228.1 Interaction with GPIHBP1. /evidence=ECO:0000269|PubMed:30559189 32..53
lipo_lipase 33..473 CDD:132274 119/388 (31%)
Essential for determining substrate specificity. /evidence=ECO:0000269|PubMed:7592706 243..266 4/26 (15%)
Important for interaction with lipoprotein particles. /evidence=ECO:0000269|PubMed:27929370 417..421 1/3 (33%)
Important for heparin binding. /evidence=ECO:0000269|PubMed:11342582 430..434 1/2 (50%)
Interaction with GPIHBP1. /evidence=ECO:0000269|PubMed:26725083, ECO:0000269|PubMed:30559189 443..467
Blue background indicates that the domain is not in the aligned region.

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