Protein Alignment CG6847 and LIPC

DIOPT Version :10

• Sequence 1: NP_573259.2
• Gene: CG6847 / 32778
• FlyBaseID: FBgn0030884
• Length: 1000
• Species: Drosophila melanogaster
• Sequence 2: NP_000227.2
• Gene: LIPC / 3990
• HGNCID: 6619
• Length: 499
• Species: Homo sapiens
• Alignment Length: 469
• Identity: 147/469 - (31%)
• Similarity: 222/469 - (47%)
• Gaps: 104/469 - (22%)

  Fly   182 DDLE--GFD-ELSVRVIVHGFG-SACPHVWIYEMKTALMA--VEDCIVICVDWENGATFPNYVRA 240
            |.|:  ||: .|.:.:|:||:. ......||::|..||.:  .:...|..|||...| ..:|..|
Human    70 DTLQECGFNSSLPLVMIIHGWSVDGVLENWIWQMVAALKSQPAQPVNVGLVDWITLA-HDHYTIA 133

  Fly   241 AANTRLVGKQLAMLLRNLQQHKGLDLMRTHVIGFSLGAHVSGFAGAELPG---LSRITGLDPAGP 302
            ..|||||||::|.|||.|::...|.....|:||:|||||||||||:.:.|   :.||||||.|||
Human   134 VRNTRLVGKEVAALLRWLEESVQLSRSHVHLIGYSLGAHVSGFAGSSIGGTHKIGRITGLDAAGP 198

  Fly   303 LFEAQHPKVRLDSSDAEFVDVIHS-NGENLILGGLGSWQPMGHVDYYPNGGRVQTGCSNLFV--- 363
            |||...|..||...||.|||.||: ..|::.| .:|..||:||.|:|||||..|.||..|.:
Human   199 LFEGSAPSNRLSPDDANFVDAIHTFTREHMGL-SVGIKQPIGHYDFYPNGGSFQPGCHFLELYRH 262

  Fly   364 ------GAVTDFIWSAQAAEDEEGRSLCNHRRAYKFFIDSV---APRCLFPAFPCGNYDDFLKGR 419
                  .|:|..|             .|:|.|:...||||:   ..:.:  |:|||:.:.|.:|.
Human   263 IAQHGFNAITQTI-------------KCSHERSVHLFIDSLLHAGTQSM--AYPCGDMNSFSQGL 312

  Fly   420 CFPCAQDDEDLAEGVPRCGNMGYYA---DRSTGRGQLYLLTREEEPFCA--HQFQLQIFNSFNDL 479
            |..|.:.         ||..:||:.   .||..: :|:|:||.:.||..  :||::|..|. .:.
Human   313 CLSCKKG---------RCNTLGYHVRQEPRSKSK-RLFLVTRAQSPFKVYHYQFKIQFINQ-TET 366

  Fly   480 PLRT------IGRLE-----AILEGDG-GLNETFEISEKDDAEFFAGDIVSKIIVPHPALGFPTT 532
            |::|      :|..|     .|..|.| ..|:|:......|.:.  |:::              .
Human   367 PIQTTFTMSLLGTKEKMQKIPITLGKGIASNKTYSFLITLDVDI--GELI--------------M 415

  Fly   533 LSLHYKSYSGWLSKGLPHWDIDKVVLTDSFGRSHSLCRPSTKLSSGSPVR-LRLQAGNCE----- 591
            :...:::.:.|.:.    ||..:.::..|.|..|          ||..:: :|::||..:
Human   416 IKFKWENSAVWANV----WDTVQTIIPWSTGPRH----------SGLVLKTIRVKAGETQQRMTF 466

  Fly   592 -LDNQEDYGAYTTQ 604
             .:|.:|.....||
Human   467 CSENTDDLLLRPTQ 480

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6847	NP_573259.2	Pancreat_lipase_like	185..459	CDD:238363	112/298 (38%)
LIPC	NP_000227.2	Lipase	24..349	CDD:395099	115/305 (38%)
		Essential for determining substrate specificity. /evidence=ECO:0000269|PubMed:7592706	254..277		5/35 (14%)
		PLAT_LPL	352..487	CDD:238856	30/160 (19%)