DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6847 and pla1a

DIOPT Version :9

Sequence 1:	NP_001285397.1	Gene:	CG6847 / 32778	FlyBaseID:	FBgn0030884	Length:	1000	Species:	Drosophila melanogaster
Sequence 2:	NP_996939.1	Gene:	pla1a / 334017	ZFINID:	ZDB-GENE-030131-5949	Length:	456	Species:	Danio rerio

Alignment Length:	349	Identity:	119/349 - (34%)
Similarity:	172/349 - (49%)	Gaps:	54/349 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   190 LSVRVIVHGF---GSACPHVWIYEMKTALMAVEDCIVICVDWENGATFPNYVRAAANTRLVGKQL 251
            |..:|||||:   ||. |. |:..:..||:..||..|:.|||..||:|. |.....|.:.|..|:
Zfish    85 LPTKVIVHGYRALGSK-PS-WVSGLAQALLREEDVNVLVVDWVYGASFA-YNLVVENYKEVAVQI 146

  Fly   252 AMLLRNLQQHKGLDLMRTHVIGFSLGAHVSGFAGAELPG-LSRITGLDPAGPLFEAQHPKVRLDS 315
            ::|:..|.:: |..|...|.||.|||||||||.|....| |.||||||||||:|::..|..||||
Zfish   147 SVLINQLTKY-GSTLESFHFIGVSLGAHVSGFVGTLFHGKLGRITGLDPAGPMFKSADPFDRLDS 210

  Fly   316 SDAEFVDVIHSNGENLILGGLGSWQPMGHVDYYPNGGRVQTGCSNLFVGAVTDFIWSAQAAEDEE 380
            |||.||:.||::.:.     .|...|:||||::.|||..|.||:.....::..::
Zfish   211 SDALFVEAIHTDSDY-----FGISIPVGHVDFFLNGGMDQAGCARSRFASMYGYV---------- 260

  Fly   381 GRSLCNHRRAYKFFIDSVAPRCLFPAFPCGNYDDFLKGRCFPCAQDDEDLAEGVPRCG---NMGY 442
               :|:|.||...::.::...|....|||..|::||.|:|..|   |:......|:.|   |.|.
Zfish   261 ---ICDHMRALHVYMSALNGSCPLIGFPCSGYEEFLAGKCITC---DDPFNGTCPQIGLLKNSGI 319

  Fly   443 YADRSTGRGQLYLLTREEEPFCAHQFQLQIFNSFND------LPLRTIGRLEAILEGDGGLNETF 501
            .|.....:.::||||....|||||...:::..|..|      |.|::||..|..|
Zfish   320 TATPLPNQEKVYLLTTASGPFCAHHILVELNVSRLDKTAEVQLILKSIGHPETEL---------- 374

  Fly   502 EISEKDDAEFFAGDIVSKIIVPHP 525
                  :.:.:..:...|.:..||
Zfish   375 ------NLKLYTDETRYKTVAAHP 392

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6847	NP_001285397.1	Lipase	70..463	CDD:278576	103/279 (37%)
CG6847	NP_001285397.1	Pancreat_lipase_like	185..459	CDD:238363	103/275 (37%)
pla1a	NP_996939.1	Lipase	21..340	CDD:278576	103/279 (37%)
pla1a	NP_996939.1	Pancreat_lipase_like	48..336	CDD:238363	103/275 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	161	1.000	Domainoid score	I3973
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D247005at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm6371
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11610
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5841
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	6.050