DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6847 and CG5966

DIOPT Version :9

Sequence 1:	NP_001285397.1	Gene:	CG6847 / 32778	FlyBaseID:	FBgn0030884	Length:	1000	Species:	Drosophila melanogaster
Sequence 2:	NP_572286.1	Gene:	CG5966 / 31532	FlyBaseID:	FBgn0029831	Length:	540	Species:	Drosophila melanogaster

Alignment Length:	475	Identity:	142/475 - (29%)
Similarity:	209/475 - (44%)	Gaps:	124/475 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 HRSRRAVKRV---------------CYGELGCFEDSGPF----AYLEMLPSSPEEINTKFYFYST 108
            |.||.||..:               |:|..|||..:||:    ..:.:.|..|.||...|..: |
  Fly    21 HTSRAAVNTLVDLPPAPKSDINEVKCFGVYGCFPINGPWNTVTRSINVHPQKPSEIEPHFTLH-T 84

  Fly   109 RQRSDRPLMELSFLNMTNAFRGKRETEVSTSSPEGTSGRSSVASAPSSMSAVNATTFTTERPGGG 173
            |:..|:|    .:|::              :.||...|...                   .|.|
  Fly    85 RRALDQP----KYLDL--------------NDPESVQGMGM-------------------NPKG- 111

  Fly   174 QKKPTPSIDDLEGFDELSVRVIVHGFGSACPHVWIYEMKTALMAVED---CIVICVDWENGATFP 235
                             .:.::|||:..:....|:::|..||:|.|.   ..|:.:||..||: |
  Fly   112 -----------------KIFLLVHGYLESGEIPWMWDMAKALLAHEPEGRASVVLIDWGGGAS-P 158

  Fly   236 NYVRAAANTRLVGKQLAMLLRNLQQHKGL-DLMRTHVIGFSLGAHVSGFAGAELP---GL--SRI 294
            .||:|.||.||||...|.::..|.:...| :|...|:||.|||||:||:||..|.   ||  :||
  Fly   159 PYVQAVANIRLVGAITAHVVHMLYEELRLPNLDNVHIIGHSLGAHLSGYAGYHLQHDFGLKPARI 223

  Fly   295 TGLDPAGPLFEAQHPKVRLDSSDAEFVDVIHSNGENLILGGLGSWQPMGHVDYYPNGGRVQTGCS 359
            ||||||.|||....|.||||.:||.|||::|::...|:.||||....:||||::||||....||:
  Fly   224 TGLDPAAPLFTDTDPIVRLDKTDAHFVDIVHTDANPLMKGGLGINMRLGHVDFFPNGGFDNPGCN 288

  Fly   360 NLFVGAV---TDFIWSAQAAEDEEGRSLCNHRRAYKFFIDSVAPRCLFPAFPCGNYDDFLKGRCF 421
            ..|...|   |.|:    ..::..|   |||.|:.::|.:|:..:|.|....|.:::.|...:|.
  Fly   289 KKFQDVVKKKTLFL----TMQEFLG---CNHIRSQQYFTESIGSQCPFLGITCDSFESFKDTKCT 346

  Fly   422 PCAQDDEDLAEGVPRCGNMGYYA----DRSTGRGQL---------YLLTREEEPFCAHQFQLQIF 473
            .|.:...       .|..|||::    ......|||         ||.|.:.:|||...:::.:
  Fly   347 SCEEPGH-------TCLRMGYHSQEDYQEQVDLGQLQQGDSPGVFYLWTGDSKPFCRLHYRITV- 403

  Fly   474 NSFNDLPLRTIGRLEAILEG 493
                    |..|..|:.|.|
  Fly   404 --------RVSGHDESTLHG 415

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6847	NP_001285397.1	Lipase	70..463	CDD:278576	129/436 (30%)
CG6847	NP_001285397.1	Pancreat_lipase_like	185..459	CDD:238363	107/298 (36%)
CG5966	NP_572286.1	Lipase	46..394	CDD:278576	129/418 (31%)
CG5966	NP_572286.1	Pancreat_lipase_like	76..390	CDD:238363	119/384 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28N19
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S7341
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D247005at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm6371
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11610
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5841
SonicParanoid	1	1.000	-	-		X699
	8	7.900