DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6847 and Lpl

DIOPT Version :9

Sequence 1:	NP_001285397.1	Gene:	CG6847 / 32778	FlyBaseID:	FBgn0030884	Length:	1000	Species:	Drosophila melanogaster
Sequence 2:	NP_036730.1	Gene:	Lpl / 24539	RGDID:	3017	Length:	474	Species:	Rattus norvegicus

Alignment Length:	388	Identity:	120/388 - (30%)
Similarity:	184/388 - (47%)	Gaps:	58/388 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   194 VIVHGFG-SACPHVWIYEMKTALMAVE-DCIVICVDWENGATFPNYVRAAANTRLVGKQLAMLLR 256
            |::||:. :.....|:.::..||...| |..||.|||...|. .:|..:|..|:|||..:|..:.
  Rat    77 VVIHGWTVTGMYESWVPKLVAALYKREPDSNVIVVDWLYRAQ-QHYPVSAGYTKLVGNDVARFIN 140

  Fly   257 NLQQHKGLDLMRTHVIGFSLGAHVSGFAGA-ELPGLSRITGLDPAGPLFEAQHPKVRLDSSDAEF 320
            .|::.....|...|::|:|||||.:|.||: ....::||||||||||.||......||...||:|
  Rat   141 WLEEEFNYPLDNVHLLGYSLGAHAAGVAGSLTNKKVNRITGLDPAGPNFEYAEAPSRLSPDDADF 205

  Fly   321 VDVIHSNGENLILGGLGSWQPMGHVDYYPNGGRVQTGCSNLFVGAVTDFIWSAQAAEDEEGRSLC 385
            |||:|:.........:|..:|:||||.|||||..|.||:   :|.....| :.:...|.:....|
  Rat   206 VDVLHTFTRGSPGRSIGIQKPVGHVDIYPNGGTFQPGCN---IGEAIRVI-AEKGLGDVDQLVKC 266

  Fly   386 NHRRAYKFFIDSVA----PRCLFPAFPCGNYDDFLKGRCFPCAQDDEDLAEGVPRCGNMGYYAD- 445
            :|.|:...||||:.    |.   .|:.|.:.:.|.||.|..|.::         ||.|:||..:
  Rat   267 SHERSIHLFIDSLLNEENPS---KAYRCNSKEAFEKGLCLSCRKN---------RCNNVGYEINK 319

  Fly   446 -RSTGRGQLYLLTREEEPFCAHQFQLQIFNSFNDLPLRTIGRLEAILEGDGGLNETFEIS----- 504
             |:....::||.||.:.|:....:|::|..|..              |.|...|:.||||
  Rat   320 VRAKRSSKMYLKTRSQMPYKVFHYQVKIHFSGT--------------ENDKQNNQAFEISLYGTV 370

  Fly   505 -EKDDAEFFAGDIV-----SKIIVPHPALGFPTTLSLHYKS-----YSGWLSKGLPHWDIDKV 556
             |.::..|...::.     |.:|.....:|....:.|.:|:     :|.|.|.  |.:.|:|:
  Rat   371 AESENIPFTLPEVATNKTYSFLIYTEVDIGELLMMKLKWKNDSYFRWSDWWSS--PSFVIEKI 431

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6847	NP_001285397.1	Lipase	70..463	CDD:278576	96/277 (35%)
CG6847	NP_001285397.1	Pancreat_lipase_like	185..459	CDD:238363	95/273 (35%)
Lpl	NP_036730.1	Interaction with GPIHBP1. /evidence=ECO:0000250\|UniProtKB:P06858	32..53
		lipo_lipase	33..472	CDD:132274	120/388 (31%)
		Pancreat_lipase_like	37..334	CDD:238363	95/273 (35%)
		Essential for determining substrate specificity. /evidence=ECO:0000250\|UniProtKB:P06858	243..266		4/26 (15%)
		PLAT_LPL	341..465	CDD:238856	23/107 (21%)
		Important for interaction with lipoprotein particles. /evidence=ECO:0000250\|UniProtKB:P06858	417..421		1/3 (33%)
		Important for heparin binding. /evidence=ECO:0000250\|UniProtKB:P06858	430..434		1/2 (50%)
		Interaction with GPIHBP1. /evidence=ECO:0000250\|UniProtKB:P06858	443..467
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D247005at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11610
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.020