Protein Alignment CG6847 and Lpl

DIOPT Version :10

• Sequence 1: NP_573259.2
• Gene: CG6847 / 32778
• FlyBaseID: FBgn0030884
• Length: 1000
• Species: Drosophila melanogaster
• Sequence 2: NP_032535.2
• Gene: Lpl / 16956
• MGIID: 96820
• Length: 474
• Species: Mus musculus
• Alignment Length: 423
• Identity: 125/423 - (29%)
• Similarity: 191/423 - (45%)
• Gaps: 85/423 - (20%)

  Fly   194 VIVHGFG-SACPHVWIYEMKTALMAVE-DCIVICVDWENGATFPNYVRAAANTRLVGKQLAMLLR 256
            |::||:. :.....|:.::..||...| |..||.|||...|. .:|..:|..|:|||..:|..:.
Mouse    77 VVIHGWTVTGMYESWVPKLVAALYKREPDSNVIVVDWLYRAQ-QHYPVSAGYTKLVGNDVARFIN 140

  Fly   257 NLQQHKGLDLMRTHVIGFSLGAHVSGFAGA-ELPGLSRITGLDPAGPLFEAQHPKVRLDSSDAEF 320
            .:::.....|...|::|:|||||.:|.||: ....::||||||||||.||......||...||:|
Mouse   141 WMEEEFNYPLDNVHLLGYSLGAHAAGVAGSLTNKKVNRITGLDPAGPNFEYAEAPSRLSPDDADF 205

  Fly   321 VDVIHSNGENLILGGLGSWQPMGHVDYYPNGGRVQTGCSNLFVGAVTDFIWSAQAAEDEEGRSLC 385
            |||:|:.........:|..:|:||||.|||||..|.||:   :|.....| :.:...|.:....|
Mouse   206 VDVLHTFTRGSPGRSIGIQKPVGHVDIYPNGGTFQPGCN---IGEAIRVI-AERGLGDVDQLVKC 266

  Fly   386 NHRRAYKFFIDSVA----PRCLFPAFPCGNYDDFLKGRCFPCAQDDEDLAEGVPRCGNMGYYAD- 445
            :|.|:...||||:.    |.   .|:.|.:.:.|.||.|..|.::         ||.|:||..:
Mouse   267 SHERSIHLFIDSLLNEENPS---KAYRCNSKEAFEKGLCLSCRKN---------RCNNLGYEINK 319

  Fly   446 -RSTGRGQLYLLTREEEPFCAHQFQLQI-FNSFNDLPLRTIGRLEAILEGDGGLNETFEIS---- 504
             |:....::||.||.:.|:....:|::| |:...|      |:..         |:.||||
Mouse   320 VRAKRSSKMYLKTRSQMPYKVFHYQVKIHFSGTED------GKQH---------NQAFEISLYGT 369

  Fly   505 --EKDDAEFFAGDI-----VSKIIVPHPALGFPTTLSLHY--KSYSGWLSKGLPHWDIDKVVLTD 560
              |.::..|...::     .|.:|.....:|....:.|.:  .||..|     |.|
Mouse   370 VAESENIPFTLPEVSTNKTYSFLIYTEVDIGELLMMKLKWISDSYFSW-----PDW--------- 420

  Fly   561 SFGRSHSLCRPSTKLSSGSPV--RLRLQAGNCE 591
                          .||.|.|  |:|::||..:
Mouse   421 --------------WSSPSFVIERIRVKAGETQ 439

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6847	NP_573259.2	Pancreat_lipase_like	185..459	CDD:238363	94/273 (34%)
Lpl	NP_032535.2	Interaction with GPIHBP1. /evidence=ECO:0000250|UniProtKB:P06858	32..53
		lipo_lipase	33..472	CDD:132274	125/423 (30%)
		Essential for determining substrate specificity. /evidence=ECO:0000250|UniProtKB:P06858	243..266		4/26 (15%)
		Important for interaction with lipoprotein particles. /evidence=ECO:0000250|UniProtKB:P06858	417..421		3/31 (10%)
		Important for heparin binding. /evidence=ECO:0000250|UniProtKB:P06858	430..434		2/3 (67%)
		Interaction with GPIHBP1. /evidence=ECO:0000250|UniProtKB:P06858	443..467