DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG6847 and Lpl

DIOPT Version :9

Sequence 1:NP_001285397.1 Gene:CG6847 / 32778 FlyBaseID:FBgn0030884 Length:1000 Species:Drosophila melanogaster
Sequence 2:NP_032535.2 Gene:Lpl / 16956 MGIID:96820 Length:474 Species:Mus musculus


Alignment Length:423 Identity:125/423 - (29%)
Similarity:191/423 - (45%) Gaps:85/423 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly   194 VIVHGFG-SACPHVWIYEMKTALMAVE-DCIVICVDWENGATFPNYVRAAANTRLVGKQLAMLLR 256
            |::||:. :.....|:.::..||...| |..||.|||...|. .:|..:|..|:|||..:|..:.
Mouse    77 VVIHGWTVTGMYESWVPKLVAALYKREPDSNVIVVDWLYRAQ-QHYPVSAGYTKLVGNDVARFIN 140

  Fly   257 NLQQHKGLDLMRTHVIGFSLGAHVSGFAGA-ELPGLSRITGLDPAGPLFEAQHPKVRLDSSDAEF 320
            .:::.....|...|::|:|||||.:|.||: ....::||||||||||.||......||...||:|
Mouse   141 WMEEEFNYPLDNVHLLGYSLGAHAAGVAGSLTNKKVNRITGLDPAGPNFEYAEAPSRLSPDDADF 205

  Fly   321 VDVIHSNGENLILGGLGSWQPMGHVDYYPNGGRVQTGCSNLFVGAVTDFIWSAQAAEDEEGRSLC 385
            |||:|:.........:|..:|:||||.|||||..|.||:   :|.....| :.:...|.:....|
Mouse   206 VDVLHTFTRGSPGRSIGIQKPVGHVDIYPNGGTFQPGCN---IGEAIRVI-AERGLGDVDQLVKC 266

  Fly   386 NHRRAYKFFIDSVA----PRCLFPAFPCGNYDDFLKGRCFPCAQDDEDLAEGVPRCGNMGYYAD- 445
            :|.|:...||||:.    |.   .|:.|.:.:.|.||.|..|.::         ||.|:||..: 
Mouse   267 SHERSIHLFIDSLLNEENPS---KAYRCNSKEAFEKGLCLSCRKN---------RCNNLGYEINK 319

  Fly   446 -RSTGRGQLYLLTREEEPFCAHQFQLQI-FNSFNDLPLRTIGRLEAILEGDGGLNETFEIS---- 504
             |:....::||.||.:.|:....:|::| |:...|      |:..         |:.||||    
Mouse   320 VRAKRSSKMYLKTRSQMPYKVFHYQVKIHFSGTED------GKQH---------NQAFEISLYGT 369

  Fly   505 --EKDDAEFFAGDI-----VSKIIVPHPALGFPTTLSLHY--KSYSGWLSKGLPHWDIDKVVLTD 560
              |.::..|...::     .|.:|.....:|....:.|.:  .||..|     |.|         
Mouse   370 VAESENIPFTLPEVSTNKTYSFLIYTEVDIGELLMMKLKWISDSYFSW-----PDW--------- 420

  Fly   561 SFGRSHSLCRPSTKLSSGSPV--RLRLQAGNCE 591
                          .||.|.|  |:|::||..:
Mouse   421 --------------WSSPSFVIERIRVKAGETQ 439

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG6847NP_001285397.1 Lipase 70..463 CDD:278576 95/277 (34%)
Pancreat_lipase_like 185..459 CDD:238363 94/273 (34%)
LplNP_032535.2 Interaction with GPIHBP1. /evidence=ECO:0000250|UniProtKB:P06858 32..53
lipo_lipase 33..472 CDD:132274 125/423 (30%)
Pancreat_lipase_like 37..334 CDD:238363 94/273 (34%)
Essential for determining substrate specificity. /evidence=ECO:0000250|UniProtKB:P06858 243..266 4/26 (15%)
PLAT_LPL 341..465 CDD:238856 29/142 (20%)
Important for interaction with lipoprotein particles. /evidence=ECO:0000250|UniProtKB:P06858 417..421 3/31 (10%)
Important for heparin binding. /evidence=ECO:0000250|UniProtKB:P06858 430..434 2/3 (67%)
Interaction with GPIHBP1. /evidence=ECO:0000250|UniProtKB:P06858 443..467
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11610
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
22.010

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