DRSC/TRiP Functional Genomics Resources

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Protein Alignment Vps4 and VPS4B

DIOPT Version :9

Sequence 1:NP_001285396.1 Gene:Vps4 / 32777 FlyBaseID:FBgn0283469 Length:442 Species:Drosophila melanogaster
Sequence 2:NP_004860.2 Gene:VPS4B / 9525 HGNCID:10895 Length:444 Species:Homo sapiens


Alignment Length:439 Identity:332/439 - (75%)
Similarity:378/439 - (86%) Gaps:5/439 - (1%)


- Green bases have known domain annotations that are detailed below.


  Fly     7 LQKAIDLVTKATEEDRNKNYAEALRLYEHGVEYFLHTIKYEAQGEKAKDSIRAKCLQYLDRAEKL 71
            |||||||.:||.:||:..||.|||:||:|.|:||||.:||||||:|||.||||||.:||||||||
Human     8 LQKAIDLASKAAQEDKAGNYEEALQLYQHAVQYFLHVVKYEAQGDKAKQSIRAKCTEYLDRAEKL 72

  Fly    72 KEYLKKGKK---KPIKEGGESSAKDDKDKKSDSDDEDGDDPEKKKLQSKLEDAIVIEKPKVQWSD 133
            |||||..:|   ||:|||..|.| |:|...||.:.| .|||||||||::|:.|||||:|.|:|||
Human    73 KEYLKNKEKKAQKPVKEGQPSPA-DEKGNDSDGEGE-SDDPEKKKLQNQLQGAIVIERPNVKWSD 135

  Fly   134 VAGLDAAKEALKEAVILPIKFPQLFTGKRIPWKGILLFGPPGTGKSYLAKAVATEANRSTFFSVS 198
            ||||:.||||||||||||||||.||||||.||:||||||||||||||||||||||||.|||||:|
Human   136 VAGLEGAKEALKEAVILPIKFPHLFTGKRTPWRGILLFGPPGTGKSYLAKAVATEANNSTFFSIS 200

  Fly   199 SSDLMSKWLGESEKLVKNLFELARQHKPSIIFIDEIDSMCSARSDNENDSVRRIKTEFLVQMQGV 263
            ||||:|||||||||||||||:|||::||||||||||||:|.:||:||:::.||||||||||||||
Human   201 SSDLVSKWLGESEKLVKNLFQLARENKPSIIFIDEIDSLCGSRSENESEAARRIKTEFLVQMQGV 265

  Fly   264 GNDTDGILVLGATNIPWVLDSAIRRRFEKRIYIPLPEAHARLVMFKIHLGNTTHVLTEQDLKELA 328
            |.|.|||||||||||||||||||||||||||||||||.|||..|||:|||.|.:.|||.|.:||.
Human   266 GVDNDGILVLGATNIPWVLDSAIRRRFEKRIYIPLPEPHARAAMFKLHLGTTQNSLTEADFRELG 330

  Fly   329 GKTEGYSGADISIVVRDALMEPVRKVQTATHFKRVSGPSPTNHEEIVNDLLVPCSPGDQGAVEMN 393
            .||:|||||||||:||||||:||||||:|||||:|.|||..:...:|:|||.||||||.||:||.
Human   331 RKTDGYSGADISIIVRDALMQPVRKVQSATHFKKVRGPSRADPNHLVDDLLTPCSPGDPGAIEMT 395

  Fly   394 WMDVPSDKLFEPPVTMRDMLKSLSRTKPTVNEDDLKKLRKFTEDFGQEG 442
            |||||.|||.||.|:|.|||:|||.|||||||.||.||:||||||||||
Human   396 WMDVPGDKLLEPVVSMSDMLRSLSNTKPTVNEHDLLKLKKFTEDFGQEG 444

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Vps4NP_001285396.1 MIT_VPS4 6..69 CDD:239141 43/61 (70%)
RecA-like_VPS4 126..296 CDD:410929 145/169 (86%)
AAA_lid_3 323..361 CDD:407720 29/37 (78%)
Vps4_C 379..439 CDD:401324 45/59 (76%)
VPS4BNP_004860.2 MIT_VPS4 6..81 CDD:239141 52/72 (72%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 77..117 21/41 (51%)
SpoVK <124..355 CDD:223540 190/230 (83%)
Vps4_C 381..441 CDD:312737 45/59 (76%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165158072
Domainoid 1 1.000 239 1.000 Domainoid score I2282
eggNOG 1 0.900 - - E1_KOG0739
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 666 1.000 Inparanoid score I761
Isobase 1 0.950 - 0 Normalized mean entropy S185
OMA 1 1.010 - - QHG53561
OrthoDB 1 1.010 - - D321685at33208
OrthoFinder 1 1.000 - - FOG0002106
OrthoInspector 1 1.000 - - otm41101
orthoMCL 1 0.900 - - OOG6_100670
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1655
SonicParanoid 1 1.000 - - X1557
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1514.650

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