DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vps4 and VPS4

DIOPT Version :9

Sequence 1:	NP_001285396.1	Gene:	Vps4 / 32777	FlyBaseID:	FBgn0283469	Length:	442	Species:	Drosophila melanogaster
Sequence 2:	NP_015499.1	Gene:	VPS4 / 856303	SGDID:	S000006377	Length:	437	Species:	Saccharomyces cerevisiae

Alignment Length:	447	Identity:	261/447 - (58%)
Similarity:	333/447 - (74%)	Gaps:	16/447 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAAGTTLQKAIDLVTKATEEDRNKNYAEALRLYEHGVEYFLHTIKYEAQGEKAKDSIRAKCLQYL 65
            |:.|..|.|.|:||.||.:.|....|.||...|.:|::|.:..:||| :..|:||.||||..:||
Yeast     1 MSTGDFLTKGIELVQKAIDLDTATQYEEAYTAYYNGLDYLMLALKYE-KNPKSKDLIRAKFTEYL 64

  Fly    66 DRAEKLKEYLKK-----GKKKPIKEGGESSAKDDKDKKSDSDDEDGDDPEKKKLQSKLEDAIVIE 125
            :|||:||::|:.     .||.| ..|..|:..:.|..:.:.:|..|:|  .|||:..|..||:.|
Yeast    65 NRAEQLKKHLESEEANAAKKSP-SAGSGSNGGNKKISQEEGEDNGGED--NKKLRGALSSAILSE 126

  Fly   126 KPKVQWSDVAGLDAAKEALKEAVILPIKFPQLFTGKRIPWKGILLFGPPGTGKSYLAKAVATEAN 190
            ||.|:|.|||||:.||||||||||||:|||.||.|.|.|..||||:|||||||||||||||||||
Yeast   127 KPNVKWEDVAGLEGAKEALKEAVILPVKFPHLFKGNRKPTSGILLYGPPGTGKSYLAKAVATEAN 191

  Fly   191 RSTFFSVSSSDLMSKWLGESEKLVKNLFELARQHKPSIIFIDEIDSMCSARSDNENDSVRRIKTE 255
             |||||||||||:|||:||||||||.||.:||::|||||||||:|::...|.:.|:::.||||||
Yeast   192 -STFFSVSSSDLVSKWMGESEKLVKQLFAMARENKPSIIFIDEVDALTGTRGEGESEASRRIKTE 255

  Fly   256 FLVQMQGVGNDTDGILVLGATNIPWVLDSAIRRRFEKRIYIPLPEAHARLVMFKIHLGNTTHVLT 320
            .||||.|||||:.|:||||||||||.||||||||||:|||||||:..||..||:|::|:|..|||
Yeast   256 LLVQMNGVGNDSQGVLVLGATNIPWQLDSAIRRRFERRIYIPLPDLAARTTMFEINVGDTPCVLT 320

  Fly   321 EQDLKELAGKTEGYSGADISIVVRDALMEPVRKVQTATHFKRVSGPSPTNHEEIVNDLLVPCSPG 385
            ::|.:.|...||||||:||::||:||||:|:||:|:|||||.||    |..:|  ...|.|||||
Yeast   321 KEDYRTLGAMTEGYSGSDIAVVVKDALMQPIRKIQSATHFKDVS----TEDDE--TRKLTPCSPG 379

  Fly   386 DQGAVEMNWMDVPSDKLFEPPVTMRDMLKSLSRTKPTVNEDDLKKLRKFTEDFGQEG 442
            |.||:||:|.|:.:|:|.||.:|::|.||::..|:||||||||.|..:||.||||||
Yeast   380 DDGAIEMSWTDIEADELKEPDLTIKDFLKAIKSTRPTVNEDDLLKQEQFTRDFGQEG 436

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vps4	NP_001285396.1	MIT_VPS4	6..69	CDD:239141	27/62 (44%)
		RecA-like_VPS4	126..296	CDD:410929	128/169 (76%)
		AAA_lid_3	323..361	CDD:407720	23/37 (62%)
		Vps4_C	379..439	CDD:401324	34/59 (58%)
VPS4	NP_015499.1	SpoVK	<11..418	CDD:223540	242/417 (58%)
		RecA-like_VPS4	127..296	CDD:410929	128/169 (76%)
		Vps4_C	373..433	CDD:401324	34/59 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157345819
Domainoid	1	1.000	207	1.000	Domainoid score	I525
eggNOG	1	0.900	-	-		E1_KOG0739
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	501	1.000	Inparanoid score	I207
Isobase	1	0.950	-	0	Normalized mean entropy	S185
OMA	1	1.010	-	-		QHG53561
OrthoFinder	1	1.000	-	-		FOG0002106
OrthoInspector	1	1.000	-	-		oto99467
orthoMCL	1	0.900	-	-		OOG6_100670
Panther	1	1.100	-	-	LDO	PTHR23074
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1655
SonicParanoid	1	1.000	-	-		X1557
TreeFam	1	0.960	-	-
	15	14.740