Protein Alignment Vps4 and KATNAL2

DIOPT Version :10

• Sequence 1: NP_573258.1
• Gene: Vps4 / 32777
• FlyBaseID: FBgn0283469
• Length: 442
• Species: Drosophila melanogaster
• Sequence 2: NP_001340828.1
• Gene: KATNAL2 / 83473
• HGNCID: 25387
• Length: 564
• Species: Homo sapiens
• Alignment Length: 455
• Identity: 168/455 - (36%)
• Similarity: 243/455 - (53%)
• Gaps: 70/455 - (15%)

  Fly     5 TTLQKAIDLVTKA-TEEDRNKNYAEALRLYEHGVEYFLHTIKYEAQGEKAKDSIRAKCLQYLDRA 68
            ||..|..|  ||: .:|..|:...:..||  ....:.||..:  .:.:..:::...:..|.:|..
Human   158 TTAGKTGD--TKSLNKEHPNQEVVDNTRL--ESANFGLHISR--IRKDSGEENAHPRRGQIIDFQ 216

  Fly    69 EKLKEYLKKGKKKPIKEGGESS-AKDDKDKKSDSDDE--------DGDDPEKKKLQSKLEDAIVI 124
            ..|.:.:|         |..|. |.:..|...|..:.        .|.:.|.::|.:.:...|.:
Human   217 GLLTDAIK---------GATSELALNTFDHNPDPSERLLKPLSAFIGMNSEMRELAAVVSRDIYL 272

  Fly   125 EKPKVQWSDVAGLDAAKEALKEAVILPIKFPQLFTGKRIPWKGILLFGPPGTGKSYLAKAVATEA 189
            ..|.::|:|:.||||||:.:||||:.||::||||||...||||:||:|||||||:.||||||||.
Human   273 HNPNIKWNDIIGLDAAKQLVKEAVVYPIRYPQLFTGILSPWKGLLLYGPPGTGKTLLAKAVATEC 337

  Fly   190 NRSTFFSVSSSDLMSKWLGESEKLVKNLFELARQHKPSIIFIDEIDSMCSAR---SDNENDSVRR 251
             ::|||::|:|.::|||.|:|||||:.||||||.|.||.||:||::|:.|.|   |..|::...|
Human   338 -KTTFFNISASTIVSKWRGDSEKLVRVLFELARYHAPSTIFLDELESVMSQRGTASGGEHEGSLR 401

  Fly   252 IKTEFLVQMQGVGNDTDGILVLGATNIPWVLDSAIRRRFEKRIYIPLPEAHARLVMF-----KIH 311
            :|||.||||.|:....|.:.||.|:|:||.||.|:.||.||||.:.||...||..|.     .:.
Human   402 MKTELLVQMDGLARSEDLVFVLAASNLPWELDCAMLRRLEKRILVDLPSREARQAMIYHWLPPVS 466

  Fly   312 LGNTTHVLTEQDLKELAGKTEGYSGADISIVVRDALMEPVRKVQTATHFKRVSGPSPTNHEEIVN 376
            ......:.||.:...|:.:||||||:||.:|.|:|.|.||||:..|..          ||:...:
Human   467 KSRALELHTELEYSVLSQETEGYSGSDIKLVCREAAMRPVRKIFDALE----------NHQSESS 521

  Fly   377 DLLVPCSPGDQGAVEMNWMDVPSDKLFEPPVTMRDMLKSLSRTKPTVNEDDLKKLRKFTEDFGQE 441
            ||     |..|       :|:         ||..|.|..|:.|||:.     |.|.:...|:.:|
Human   522 DL-----PRIQ-------LDI---------VTTADFLDVLTHTKPSA-----KNLAQRYSDWQRE 560

  Fly   442  441
            Human   561  560

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vps4	NP_573258.1	MIT_VPS4	6..69	CDD:239141	13/63 (21%)
		RecA-like_VPS4	126..296	CDD:410929	99/172 (58%)
		AAA_lid_3	323..361	CDD:465537	18/37 (49%)
		Vps4_C	379..439	CDD:462762	14/59 (24%)
KATNAL2	NP_001340828.1	LisH	51..81	CDD:128913
		RPT1	212..548	CDD:440835	151/381 (40%)
		RecA-like_VPS4-like	282..446	CDD:410917	96/164 (59%)