DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Vps4 and Katnal2

DIOPT Version :9

Sequence 1:NP_001285396.1 Gene:Vps4 / 32777 FlyBaseID:FBgn0283469 Length:442 Species:Drosophila melanogaster
Sequence 2:NP_001355584.1 Gene:Katnal2 / 71206 MGIID:1924234 Length:539 Species:Mus musculus


Alignment Length:513 Identity:177/513 - (34%)
Similarity:251/513 - (48%) Gaps:125/513 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MAAGTTLQKAIDLVTKATEEDRNKNYAEALRLYEHGVEYFLHTIKYEAQGEKAKDSI-------- 57
            |.|...|::...|..:..|...|.:....|..||.  .||:...||....:||.|.:        
Mouse    43 MDAAKALEEETKLGLRRFEVCDNVDLETILMEYES--YYFVKFQKYPKVVKKAPDPVENNLPSRS 105

  Fly    58 --RAKCL-----QYLDR-----------------AEKLKEYLKKGKKKPIKEGGESS-------- 90
              :.|.|     |.|.:                 .:.:||:||:.|:.......||:        
Mouse   106 GGKNKRLTNDSCQNLPKICHQKSRPKTSAVKTGDTKSVKEHLKQVKESVTDTQAESTDFGLNISK 170

  Fly    91 -AKDDKDKKSD-------------SDD-------------EDGDDP----------------EKK 112
             .||..::|:.             ||.             |...||                |.:
Mouse   171 IHKDQPEEKAQPRRGQIIDFRGLLSDAIKGATSEFALNTFECNPDPSERLLKPLSAFIGMNSEMR 235

  Fly   113 KLQSKLEDAIVIEKPKVQWSDVAGLDAAKEALKEAVILPIKFPQLFTGKRIPWKGILLFGPPGTG 177
            :|.:.:...|.:..|.::|:|:.||||||:.:||||:.||::||||||...||||:||:||||||
Mouse   236 ELAAVVSRDIYLHNPNIKWNDIIGLDAAKQLVKEAVVYPIRYPQLFTGILSPWKGLLLYGPPGTG 300

  Fly   178 KSYLAKAVATEANRSTFFSVSSSDLMSKWLGESEKLVKNLFELARQHKPSIIFIDEIDSMCSARS 242
            |:.||||||||. ::|||::|:|.::|||.|:|||||:.||||||.|.||.||:||::|:.|.|.
Mouse   301 KTLLAKAVATEC-KTTFFNISASTIVSKWRGDSEKLVRVLFELARYHAPSTIFLDELESVMSQRG 364

  Fly   243 ---DNENDSVRRIKTEFLVQMQGVGNDTDGILVLGATNIPWVLDSAIRRRFEKRIYIPLPEAHAR 304
               ..|::...|:|||.||||.|:....|.:.||.|:|:||.||.|:.||.||||.:.||...||
Mouse   365 MVPGGEHEGSLRMKTELLVQMDGLARSEDLVFVLAASNLPWELDCAMLRRLEKRILVDLPSQEAR 429

  Fly   305 LVMFKIHLG--NTTHVL---TEQDLKELAGKTEGYSGADISIVVRDALMEPVRKVQTATHFKRVS 364
            ..|....|.  :..|.|   |:.:...|:.:||||||:||.:|.|:|.|.||||:.:...     
Mouse   430 QAMIYHWLPPVSKNHALELHTQLEYSVLSQETEGYSGSDIKLVCREAAMRPVRKIFSVLE----- 489

  Fly   365 GPSPTNHEEIVNDLLVPCSPGDQGAVEMNWMDVPSDKLFEPPVTMRDMLKSLSRTKPT 422
                 |::...|:|     ||.|       :|.         ||.:|.|..|:.|||:
Mouse   490 -----NNQSESNNL-----PGIQ-------LDT---------VTTQDFLDVLAHTKPS 521

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Vps4NP_001285396.1 MIT_VPS4 6..69 CDD:239141 18/94 (19%)
RecA-like_VPS4 126..296 CDD:410929 98/172 (57%)
AAA_lid_3 323..361 CDD:407720 17/37 (46%)
Vps4_C 379..439 CDD:401324 12/44 (27%)
Katnal2NP_001355584.1 LisH 25..55 CDD:128913 3/11 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 93..121 5/27 (19%)
SpoVK <239..523 CDD:223540 140/315 (44%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D787710at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.920

Return to query results.
Submit another query.