Protein Alignment Vps4 and spast

DIOPT Version :10

• Sequence 1: NP_573258.1
• Gene: Vps4 / 32777
• FlyBaseID: FBgn0283469
• Length: 442
• Species: Drosophila melanogaster
• Sequence 2: XP_012818464.1
• Gene: spast / 549207
• XenbaseID: XB-GENE-947839
• Length: 603
• Species: Xenopus tropicalis
• Alignment Length: 519
• Identity: 163/519 - (31%)
• Similarity: 250/519 - (48%)
• Gaps: 130/519 - (25%)

  Fly    11 IDLVTKATEEDRNKNYAEALRLYEHGVE------------------------------------- 38
            |.:..:..||::::. .:|::.|:.|:|
 Frog   121 ISMALRIDEEEKDQK-EQAIQWYKKGIEELEKGIAVTITGKGEQYDRARRLQAKMSTNLLMAKDR 184

  Fly    39 -YFLHTIKYEAQG-----EKAKDSIRAKCLQYLDRAEKLKEYLKK-------------------- 77
             ..|..:|.:.||     |...|:....|...|.:.||.....||
 Frog   185 LQLLAKLKADIQGQHSQMEVCSDNTNLPCRNGLLKPEKGAVPKKKDPPSISSNSYSRVKAAPKSG 249

  Fly    78 -------------------GKKKPIKEG--GESSAKDDKDKKSDSDDEDGDDPEKKKLQSKLEDA 121
                               |...|...|  |:::.:.:|.....:.....|....:.:.|.|.:.
 Frog   250 SLGNRIPNCTGVSSSARQAGPNAPSNRGAAGKNNTRTNKPTTPTTAVRKKDMKNLRNVDSNLANL 314

  Fly   122 IVIE----KPKVQWSDVAGLDAAKEALKEAVILPIKFPQLFTGKRIPWKGILLFGPPGTGKSYLA 182
            |:.|    .|.|:::|:||.|.||:||:|.||||...|:||||.|.|.:|:|||||||.||:.||
 Frog   315 ILNEIVDSGPTVKFADIAGQDLAKQALQEIVILPSIRPELFTGLRAPARGLLLFGPPGNGKTMLA 379

  Fly   183 KAVATEANRSTFFSVSSSDLMSKWLGESEKLVKNLFELARQHKPSIIFIDEIDSMCSARSDNEND 247
            ||||.|:| :|||::|::.|.||::||.||||:.||.:||:.:||||||||:||:...|.:.|:|
 Frog   380 KAVAAESN-ATFFNISAASLTSKYVGEGEKLVRALFSVARELQPSIIFIDEVDSLLCERREGEHD 443

  Fly   248 SVRRIKTEFLVQMQGV--GNDTDGILVLGATNIPWVLDSAIRRRFEKRIYIPLPEAHARLVMFKI 310
            :.||:|||||::..||  |.| |.:||:||||.|..||.|:.|||.||:|:.||....||::.|.
 Frog   444 ASRRLKTEFLIEFDGVQSGGD-DRVLVMGATNRPQELDDAVLRRFTKRVYVSLPNEETRLLLLKN 507

  Fly   311 HLGNTTHVLTEQDLKELAGKTEGYSGADISIVVRDALMEPVRKVQTATHFKRVSGPSPTNHEEIV 375
            .|....:.|.|::|.:|:..||||||:||:.:.:||.:.|:|:::.               |::.
 Frog   508 LLSKQGNPLNEKELTQLSRLTEGYSGSDITALAKDAALGPIRELKP---------------EQVK 557

  Fly   376 NDLLVPCSPGDQGAVEMNWMDVPSDKLFEPPVTMRDMLKSLSRTKPTVNEDDLKKLRKFTEDFG 439
            |          ..|.||.            .:...|.|.||.:.|.:|:...|:...::.::||
 Frog   558 N----------MAASEMR------------NIKYSDFLSSLKKIKCSVSPSTLESYIRWNKEFG 599

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vps4	NP_573258.1	MIT_VPS4	6..69	CDD:239141	15/100 (15%)
		RecA-like_VPS4	126..296	CDD:410929	97/171 (57%)
		AAA_lid_3	323..361	CDD:465537	14/37 (38%)
		Vps4_C	379..439	CDD:462762	10/59 (17%)
spast	XP_012818464.1	MIT_spastin	110..188	CDD:239142	7/67 (10%)
		RecA-like_spastin	330..493	CDD:410932	95/164 (58%)
		AAA_lid_3	520..554	CDD:465537	14/48 (29%)
		Vps4_C	<567..599	CDD:462762	7/31 (23%)