DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Vps4 and nmd

DIOPT Version :9

Sequence 1:	NP_001285396.1	Gene:	Vps4 / 32777	FlyBaseID:	FBgn0283469	Length:	442	Species:	Drosophila melanogaster
Sequence 2:	NP_001285801.1	Gene:	nmd / 44021	FlyBaseID:	FBgn0005322	Length:	369	Species:	Drosophila melanogaster

Alignment Length:	260	Identity:	100/260 - (38%)
Similarity:	154/260 - (59%)	Gaps:	18/260 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   129 VQWSDVAGLDAAKEALKEAVILPIKFPQLFTGKRIPW---KGILLFGPPGTGKSYLAKAVATEAN 190
            |.|:|:||||:..:.|:|:|:|||:...||...:: |   ||:||.||||.||:.:|||.|.||.
  Fly    94 VSWADIAGLDSVIQELRESVVLPIQHKDLFKHSKL-WQAPKGVLLHGPPGCGKTLIAKATAKEAG 157

  Fly   191 RSTFFSVSSSDLMSKWLGESEKLVKNLFELARQHKPSIIFIDEIDSMCSARSDNENDSVRRIKTE 255
             ..|.::..:.|..||.|||:||...:|.||.:.:|.|||||||||...:|:.|::::...:||:
  Fly   158 -MRFINLDVAILTDKWYGESQKLTSAVFSLASRIEPCIIFIDEIDSFLRSRNMNDHEATAMMKTQ 221

  Fly   256 FLVQMQGVG-NDTDGILVLGATNIPWVLDSAIRRRFEKRIYIPLPEAHARLVMFKIHLGNTTHVL 319
            |::...|:. |....::|:||||.|..||.||.||...:.:|.||....|..:.|:.| .:..|.
  Fly   222 FMMLWDGLSTNANSTVIVMGATNRPQDLDKAIVRRMPAQFHIGLPSETQRKDILKLIL-QSEEVS 285

  Fly   320 TEQDLKELAGKTEGYSGADISIVVRDALMEPVRKVQTATHFKRVSGPSPT----NHEEI-VNDLL 379
            .:.||..|:..|.|:||:|:..:.|:|.:..:|::.|:      ..||.|    |:..| ::|||
  Fly   286 QDVDLNRLSKLTNGFSGSDLREMCRNASVYRMRQLITS------RDPSATALDRNNVRITMDDLL 344

Fly 380 379
Fly 345 344

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vps4	NP_001285396.1	MIT_VPS4	6..69	CDD:239141
		RecA-like_VPS4	126..296	CDD:410929	73/170 (43%)
		AAA_lid_3	323..361	CDD:407720	12/37 (32%)
		Vps4_C	379..439	CDD:401324	1/1 (100%)
nmd	NP_001285801.1	AAA	132..266	CDD:214640	58/134 (43%)
nmd	NP_001285801.1	AAA	135..265	CDD:278434	56/130 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467090
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840