DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Vps4 and spas

DIOPT Version :9

Sequence 1:	NP_001285396.1	Gene:	Vps4 / 32777	FlyBaseID:	FBgn0283469	Length:	442	Species:	Drosophila melanogaster
Sequence 2:	NP_651206.3	Gene:	spas / 42846	FlyBaseID:	FBgn0039141	Length:	758	Species:	Drosophila melanogaster

Alignment Length:	331	Identity:	138/331 - (41%)
Similarity:	202/331 - (61%)	Gaps:	40/331 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   111 KKKLQSKLEDAIVIEKPKVQWSDVAGLDAAKEALKEAVILPIKFPQLFTGKRIPWKGILLFGPPG 175
            ::||...:.|.||....||:|:|:||.|.||:||:|.||||...|:||||.|.|.||:|||||||
  Fly   462 EQKLVQLILDEIVEGGAKVEWTDIAGQDVAKQALQEMVILPSVRPELFTGLRAPAKGLLLFGPPG 526

  Fly   176 TGKSYLAKAVATEANRSTFFSVSSSDLMSKWLGESEKLVKNLFELARQHKPSIIFIDEIDSMCSA 240
            .||:.||:|||||.: :||.::|::.|.||::|:.||||:.||.:||..:||||||||:||:.|.
  Fly   527 NGKTLLARAVATECS-ATFLNISAASLTSKYVGDGEKLVRALFAVARHMQPSIIFIDEVDSLLSE 590

  Fly   241 RSDNENDSVRRIKTEFLVQMQGV-GN-DTDGILVLGATNIPWVLDSAIRRRFEKRIYIPLPEAHA 303
            ||.:|:::.||:||||||:..|: || |.|.|:||.|||.|..||.|..|||.||:|:.||:...
  Fly   591 RSSSEHEASRRLKTEFLVEFDGLPGNPDGDRIVVLAATNRPQELDEAALRRFTKRVYVSLPDEQT 655

  Fly   304 RLVMFKIHLGNTTHVLTEQDLKELAGKTEGYSGADISIVVRDALMEPVRKVQTATHFKRVSGPSP 368
            |.::....|......|..:.|:.||..|:||||:|::.:.:||.:||:|::
  Fly   656 RELLLNRLLQKQGSPLDTEALRRLAKITDGYSGSDLTALAKDAALEPIREL-------------- 706

  Fly   369 TNHEEIVNDLLVPCSPGDQGAVEMNWMDVPSDKLFEPPVTMRDMLKSLSRTKPTVNEDDLKKLRK 433
             |.|:      |.|            :|:.:.:    .:|.:|...||.|.:.:|....|....|
  Fly   707 -NVEQ------VKC------------LDISAMR----AITEQDFHSSLKRIRRSVAPQSLNSYEK 748

  Fly   434 FTEDFG 439
            :::|:|
  Fly   749 WSQDYG 754

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vps4	NP_001285396.1	MIT_VPS4	6..69	CDD:239141
		RecA-like_VPS4	126..296	CDD:410929	98/171 (57%)
		AAA_lid_3	323..361	CDD:407720	14/37 (38%)
		Vps4_C	379..439	CDD:401324	12/59 (20%)
spas	NP_651206.3	MIT_spastin	230..308	CDD:239142
		P-loop_NTPase	482..>538	CDD:304359	36/55 (65%)
		AAA	515..652	CDD:214640	78/137 (57%)
		AAA	519..650	CDD:278434	74/131 (56%)
		Vps4_C	<722..754	CDD:286426	9/31 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467080
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D59575at33392
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23074
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.950