Protein Alignment Vps4 and FIGNL2

DIOPT Version :10

• Sequence 1: NP_573258.1
• Gene: Vps4 / 32777
• FlyBaseID: FBgn0283469
• Length: 442
• Species: Drosophila melanogaster
• Sequence 2: XP_016874787.1
• Gene: FIGNL2 / 401720
• HGNCID: 13287
• Length: 767
• Species: Homo sapiens
• Alignment Length: 458
• Identity: 114/458 - (24%)
• Similarity: 189/458 - (41%)
• Gaps: 93/458 - (20%)

  Fly     8 QKAIDLVTKATE---EDRNKNYAEALRLYEHGVEYFLHTIKYEA--QGEKAKDSIRAKCLQYLDR 67
            :..:.|..||.:   |.|.:.||     ||...........|.|  .||...:..|||.....:.
Human   374 ESGLSLKRKAADEGPEGRYRKYA-----YEPAKAPVADGASYPAADNGECRGNGFRAKPPGAAEE 433

  Fly    68 AE-------------------KLKEYLKKGKKKPIKEGGESSAKDDKDKKSDSDDEDGDDPEKKK 113
            |.                   :|:.:.|..::.|...||.:....:..|        |.||...:
Human   434 ASGKYGGGVPLKVLGSPVYGPQLEPFEKFPERAPAPRGGFAVPSGETPK--------GVDPGALE 490

  Fly   114 L-QSKLEDAIVIEKPKVQWSDVAGLDAAKEALKEAVILPIKFPQLFTGKRIPWKGILLFGPPGTG 177
            | .||:.|.    .|.|||:||||..|.|.||:|.::.|:..|..:.|...|.:.:|||||.|.|
Human   491 LVTSKMVDC----GPPVQWADVAGQGALKAALEEELVWPLLRPPAYPGSLRPPRTVLLFGPRGAG 551

  Fly   178 KSYLAKAVATEANRSTFFSVSSSDLMSKWLGESEKLVKNLFELARQHKPSIIFIDEIDSMCSARS 242
            |:.|.:.:||:.. :|...:..:.|.:....|..:|::..|..||...||::.|.|::::..||.
Human   552 KALLGRCLATQLG-ATLLRLRGATLAAPGAAEGARLLQAAFAAARCRPPSVLLISELEALLPARD 615

  Fly   243 DNENDSVRRIKTEFLVQMQ-GVGNDTDGILVLGATNIPWVLDSAIRRRFEKRIYIPLPEAHARLV 306
            |.. .:...::...|..:. |.|...||:||:|.|:.|..||.|.||||..|.|:.||::.||..
Human   616 DGA-AAGGALQVPLLACLDGGCGAGADGVLVVGTTSRPAALDEATRRRFSLRFYVALPDSPARGQ 679

  Fly   307 MFKIHLGNTTHVLTEQDLKELAGKTEGYSGADISIVVRDALMEPVRKVQTATHFKRVSGPSPTNH 371
            :.:..|......|:|::|..|...|:|:||.::..:
Human   680 ILQRALAQQGCALSERELAALVQGTQGFSGGELGQL----------------------------- 715

  Fly   372 EEIVNDLLVPCSPGDQGAVEMNWMDVPSDKLFEPPVTMRDMLKSLSRTKPTVNEDDLKKLRKFTE 436
                      |.....||      .:|.   .:.|::.:|:..:|::..|..:..:|....::.:
Human   716 ----------CQQAAAGA------GLPG---LQRPLSYKDLEAALAKVGPRASAKELDSFVEWDK 761

  Fly   437 DFG 439
            .:|
Human   762 MYG 764

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vps4	NP_573258.1	MIT_VPS4	6..69	CDD:239141	16/65 (25%)
		RecA-like_VPS4	126..296	CDD:410929	60/170 (35%)
		AAA_lid_3	323..361	CDD:465537	6/37 (16%)
		Vps4_C	379..439	CDD:462762	9/59 (15%)
FIGNL2	XP_016874787.1	RecA-like_fidgetin	507..669	CDD:410931	56/163 (34%)
		HflB	<643..>720	CDD:440233	28/115 (24%)