Protein Alignment Vps4 and Spast

DIOPT Version :10

• Sequence 1: NP_573258.1
• Gene: Vps4 / 32777
• FlyBaseID: FBgn0283469
• Length: 442
• Species: Drosophila melanogaster
• Sequence 2: XP_008762708.1
• Gene: Spast / 362700
• RGDID: 1308494
• Length: 614
• Species: Rattus norvegicus
• Alignment Length: 524
• Identity: 160/524 - (30%)
• Similarity: 248/524 - (47%)
• Gaps: 133/524 - (25%)

  Fly    11 IDLVTKATEEDRNKNYAEALRLYEHGVEYFLHTIK--YEAQGEKAKDSIRAKC------------ 61
            |.:..:..||::.....:|:..|:.|:|.....|.  ...|||:.:.:.|.:.
  Rat   125 ISIALRIDEEEKAGQKEQAVEWYKKGIEELEKGIAVIVTGQGEQYERARRLQAKMMTNLVMAKDR 189

  Fly    62 LQYLDRAEKLKEYLKK--------------------------GKKKPIKEGGESSAKDDKDKKSD 100
            ||.|::.:.:.::.|.                          .||.|:.....|..:.....||.
  Rat   190 LQLLEKLQPVLQFSKSQTDVYNESTNLTCRNGHLQSESGAVPKKKDPLTHASNSLPRSKTVMKSG 254

  Fly   101 SDD-------------------EDGDDP------------------------EKKK--------- 113
            |..                   ..|..|                        .|||
  Rat   255 STGLSGHHRAPSCSGLSMVSGARPGSGPAATTHKGTSKPNRTNKPSTPTTAVRKKKDLKNFRNVD 319

  Fly   114 --LQSKLEDAIVIEKPKVQWSDVAGLDAAKEALKEAVILPIKFPQLFTGKRIPWKGILLFGPPGT 176
              |.:.:.:.||.....|::.|:||.:.||:||:|.||||...|:||||.|.|.:|:|||||||.
  Rat   320 SNLANLIMNEIVDNGTAVKFDDIAGQELAKQALQEIVILPSLRPELFTGLRAPARGLLLFGPPGN 384

  Fly   177 GKSYLAKAVATEANRSTFFSVSSSDLMSKWLGESEKLVKNLFELARQHKPSIIFIDEIDSMCSAR 241
            ||:.||||||.|:| :|||::|::.|.||::||.||||:.||.:||:.:||||||||:||:...|
  Rat   385 GKTMLAKAVAAESN-ATFFNISAASLTSKYVGEGEKLVRALFAVARELQPSIIFIDEVDSLLCER 448

  Fly   242 SDNENDSVRRIKTEFLVQMQGVGN-DTDGILVLGATNIPWVLDSAIRRRFEKRIYIPLPEAHARL 305
            .:.|:|:.||:|||||::..||.: ..|.:||:||||.|..||.|:.|||.||:|:.||....||
  Rat   449 REGEHDASRRLKTEFLIEFDGVQSAGDDRVLVMGATNRPQELDEAVLRRFIKRVYVSLPNEETRL 513

  Fly   306 VMFKIHLGNTTHVLTEQDLKELAGKTEGYSGADISIVVRDALMEPVRKVQTATHFKRVSGPSPTN 370
            ::.|..|......||:::|.:||..|:||||:|::.:.:||.:.|:|:::.
  Rat   514 LLLKNLLCKQGSPLTQKELAQLARMTDGYSGSDLTALAKDAALGPIRELKP-------------- 564

  Fly   371 HEEIVNDLLVPCSPGDQGAVEMNWMDVPSDKLFEPPVTMRDMLKSLSRTKPTVNEDDLKKLRKFT 435
             |::.|          ..|.||.            .:.:.|..:||.:.|.:|:...|:...::.
  Rat   565 -EQVKN----------MSASEMR------------NIRLSDFTESLKKIKRSVSPQTLEAYIRWN 606

  Fly   436 EDFG 439
            :|||
  Rat   607 KDFG 610

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vps4	NP_573258.1	MIT_VPS4	6..69	CDD:239141	15/71 (21%)
		RecA-like_VPS4	126..296	CDD:410929	93/170 (55%)
		AAA_lid_3	323..361	CDD:465537	13/37 (35%)
		Vps4_C	379..439	CDD:462762	10/59 (17%)
Spast	XP_008762708.1	MIT_spastin	114..193	CDD:239142	14/67 (21%)
		RecA-like_spastin	341..504	CDD:410932	92/163 (56%)
		AAA_lid_3	531..585	CDD:465537	19/90 (21%)
		Vps4_C	<578..610	CDD:462762	7/31 (23%)