DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Vps4 and CG10793

DIOPT Version :9

Sequence 1:	NP_001285396.1	Gene:	Vps4 / 32777	FlyBaseID:	FBgn0283469	Length:	442	Species:	Drosophila melanogaster
Sequence 2:	NP_570054.2	Gene:	CG10793 / 31308	FlyBaseID:	FBgn0029656	Length:	479	Species:	Drosophila melanogaster

Alignment Length:	345	Identity:	119/345 - (34%)
Similarity:	187/345 - (54%)	Gaps:	52/345 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 IKYEAQGEKAKDSIRAKCLQYLDRAEKLKEYLKKGKKKP----------IKEGGESSAKDDKD-- 96
            ||.|..|.||.:...||.|.               ||.|          |..|..:.|..::.
  Fly    99 IKVEMGGGKAHEKTPAKELP---------------KKPPTTDASLANWHIGVGAATQALSNEQPL 148

  Fly    97 --KK----SDSDDED-----------GDDP-----EKKKLQSKLEDAIVIEKPKVQWSDVAGLDA 139
              ||    ::|:.:|           |||.     |.:.|...::.:|:.|..|::||||.|...
  Fly   149 QIKKMETATESNGQDNACEIEHVHLGGDDVLFSSLEWQSLAELVKTSILQENIKIKWSDVCGNQR 213

  Fly   140 AKEALKEAVILPIKFPQLFTGKRIPWKGILLFGPPGTGKSYLAKAVATEA-NRSTFFSVSSSDLM 203
            |.|.:||||:.||:|||||.....||:.:||.||||:||:.||||:.:|. .:.|||::::|.::
  Fly   214 AIELIKEAVLTPIEFPQLFAHGLKPWRSLLLHGPPGSGKTLLAKALYSETQGQVTFFNITASIMV 278

  Fly   204 SKWLGESEKLVKNLFELARQHKPSIIFIDEIDSMCSARS-DNENDSVRRIKTEFLVQMQGVGNDT 267
            |||.|||||:::.||.:|.:..||:||.|||:|:.|.|. ..:::|.:|.|.|.|..:.|:.:..
  Fly   279 SKWRGESEKILRVLFHMAAKRAPSVIFFDEIESLTSKRDRATDHESSKRFKNELLQLLDGMEHSL 343

  Fly   268 DGILVLGATNIPWVLDSAIRRRFEKRIYIPLPEAHARLVMFKIHLGNTTHVLTEQDLKELAGKTE 332
            :|:.||.:||:||.:|.|..|||||::.:.||.|..|..:....||::.. |..:.|::|...::
  Fly   344 NGVFVLASTNLPWDIDEAFLRRFEKKLLVQLPNAAERSCLINRLLGSSIS-LNPRLLEQLVEISD 407

  Fly   333 GYSGADISIVVRDALMEPVR 352
            .::|.:|.:..::..|..||
  Fly   408 HFTGDEIRLACKEISMHRVR 427

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vps4	NP_001285396.1	MIT_VPS4	6..69	CDD:239141	9/24 (38%)
		RecA-like_VPS4	126..296	CDD:410929	79/171 (46%)
		AAA_lid_3	323..361	CDD:407720	7/30 (23%)
		Vps4_C	379..439	CDD:401324
CG10793	NP_570054.2	LisH	31..56	CDD:285685
		P-loop_NTPase	205..>259	CDD:304359	31/53 (58%)
		AAA	238..376	CDD:214640	61/137 (45%)
		AAA	242..374	CDD:278434	58/131 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467094
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D787710at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23074
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.950