Protein Alignment Vps4 and Vps4b

DIOPT Version :10

• Sequence 1: NP_573258.1
• Gene: Vps4 / 32777
• FlyBaseID: FBgn0283469
• Length: 442
• Species: Drosophila melanogaster
• Sequence 2: NP_033216.2
• Gene: Vps4b / 20479
• MGIID: 1100499
• Length: 444
• Species: Mus musculus
• Alignment Length: 442
• Identity: 333/442 - (75%)
• Similarity: 381/442 - (86%)
• Gaps: 1/442 - (0%)

  Fly     2 AAGTTLQKAIDLVTKATEEDRNKNYAEALRLYEHGVEYFLHTIKYEAQGEKAKDSIRAKCLQYLD 66
            :..|.|||||||.:||.:||:..||.|||:||:|.|:||||.:||||||:|||.||||||.:|||
Mouse     3 STNTNLQKAIDLASKAAQEDKAGNYEEALQLYQHAVQYFLHVVKYEAQGDKAKQSIRAKCTEYLD 67

  Fly    67 RAEKLKEYLKKGKKKPIKEGGESSAKDDKDKKSDSDDE-DGDDPEKKKLQSKLEDAIVIEKPKVQ 130
            |||||||||||.:|||.|...|..:....:|.:|||.| :.|||||||||::|:.|||||:|.|:
Mouse    68 RAEKLKEYLKKKEKKPQKPVKEEQSGPVDEKGNDSDGEAESDDPEKKKLQNQLQGAIVIERPNVK 132

  Fly   131 WSDVAGLDAAKEALKEAVILPIKFPQLFTGKRIPWKGILLFGPPGTGKSYLAKAVATEANRSTFF 195
            |||||||:.||||||||||||||||.||||||.||:||||||||||||||||||||||||.||||
Mouse   133 WSDVAGLEGAKEALKEAVILPIKFPHLFTGKRTPWRGILLFGPPGTGKSYLAKAVATEANNSTFF 197

  Fly   196 SVSSSDLMSKWLGESEKLVKNLFELARQHKPSIIFIDEIDSMCSARSDNENDSVRRIKTEFLVQM 260
            |:|||||:|||||||||||||||:|||::||||||||||||:|.:||:||:::.|||||||||||
Mouse   198 SISSSDLVSKWLGESEKLVKNLFQLARENKPSIIFIDEIDSLCGSRSENESEAARRIKTEFLVQM 262

  Fly   261 QGVGNDTDGILVLGATNIPWVLDSAIRRRFEKRIYIPLPEAHARLVMFKIHLGNTTHVLTEQDLK 325
            ||||.|.|||||||||||||||||||||||||||||||||||||..||::|||:|.:.|||.|.:
Mouse   263 QGVGVDNDGILVLGATNIPWVLDSAIRRRFEKRIYIPLPEAHARAAMFRLHLGSTQNSLTEADFQ 327

  Fly   326 ELAGKTEGYSGADISIVVRDALMEPVRKVQTATHFKRVSGPSPTNHEEIVNDLLVPCSPGDQGAV 390
            ||..||:|||||||||:||||||:||||||:|||||:|.|||..:...||||||.||||||.||:
Mouse   328 ELGRKTDGYSGADISIIVRDALMQPVRKVQSATHFKKVRGPSRADPNCIVNDLLTPCSPGDPGAI 392

  Fly   391 EMNWMDVPSDKLFEPPVTMRDMLKSLSRTKPTVNEDDLKKLRKFTEDFGQEG 442
            ||.|||||.|||.||.|:|.|||:|||.|||||||.||.||:||||||||||
Mouse   393 EMTWMDVPGDKLLEPVVSMWDMLRSLSSTKPTVNEQDLLKLKKFTEDFGQEG 444

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vps4	NP_573258.1	MIT_VPS4	6..69	CDD:239141	43/62 (69%)
		RecA-like_VPS4	126..296	CDD:410929	145/169 (86%)
		AAA_lid_3	323..361	CDD:465537	29/37 (78%)
		Vps4_C	379..439	CDD:462762	45/59 (76%)
Vps4b	NP_033216.2	MIT_VPS4	7..69	CDD:239141	42/61 (69%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	77..118		20/40 (50%)
		RecA-like_VPS4	128..298	CDD:410929	145/169 (86%)
		AAA_lid_3	325..366	CDD:465537	31/40 (78%)
		Vps4_C	381..441	CDD:462762	45/59 (76%)