Protein Alignment Vps4 and Vps4a

DIOPT Version :10

• Sequence 1: NP_573258.1
• Gene: Vps4 / 32777
• FlyBaseID: FBgn0283469
• Length: 442
• Species: Drosophila melanogaster
• Sequence 2: NP_569053.1
• Gene: Vps4a / 116733
• MGIID: 1890520
• Length: 437
• Species: Mus musculus
• Alignment Length: 440
• Identity: 330/440 - (75%)
• Similarity: 379/440 - (86%)
• Gaps: 10/440 - (2%)

  Fly     5 TTLQKAIDLVTKATEEDRNKNYAEALRLYEHGVEYFLHTIKYEAQGEKAKDSIRAKCLQYLDRAE 69
            :||||||||||||||||:.|||.||||||:|.||||||.|||||..:|||:||||||:|||||||
Mouse     4 STLQKAIDLVTKATEEDKAKNYEEALRLYQHAVEYFLHAIKYEAHSDKAKESIRAKCMQYLDRAE 68

  Fly    70 KLKEYLK---KGKKKPIKEGGESSAKDDKDKKSDSDDEDGDDPEKKKLQSKLEDAIVIEKPKVQW 131
            |||:||:   |..|||:||      ...:.|.||||.| ||:|||||||.:|..|:|:|||.::|
Mouse    69 KLKDYLRNKEKHGKKPVKE------NQSEGKGSDSDSE-GDNPEKKKLQEQLMGAVVMEKPNIRW 126

  Fly   132 SDVAGLDAAKEALKEAVILPIKFPQLFTGKRIPWKGILLFGPPGTGKSYLAKAVATEANRSTFFS 196
            :|||||:.||||||||||||||||.||||||.||:||||||||||||||||||||||||.|||||
Mouse   127 NDVAGLEGAKEALKEAVILPIKFPHLFTGKRTPWRGILLFGPPGTGKSYLAKAVATEANNSTFFS 191

  Fly   197 VSSSDLMSKWLGESEKLVKNLFELARQHKPSIIFIDEIDSMCSARSDNENDSVRRIKTEFLVQMQ 261
            |||||||||||||||||||||||||||||||||||||:||:|.:|::||:::.||||||||||||
Mouse   192 VSSSDLMSKWLGESEKLVKNLFELARQHKPSIIFIDEVDSLCGSRNENESEAARRIKTEFLVQMQ 256

  Fly   262 GVGNDTDGILVLGATNIPWVLDSAIRRRFEKRIYIPLPEAHARLVMFKIHLGNTTHVLTEQDLKE 326
            ||||:.||.||||||||||||||||||||||||||||||..||..||::|||:|.|.||:.::.|
Mouse   257 GVGNNNDGTLVLGATNIPWVLDSAIRRRFEKRIYIPLPEEAARAQMFRLHLGSTPHNLTDANIHE 321

  Fly   327 LAGKTEGYSGADISIVVRDALMEPVRKVQTATHFKRVSGPSPTNHEEIVNDLLVPCSPGDQGAVE 391
            ||.||||||||||||:|||:||:||||||:|||||:|.|||.||...:::|||.||||||.||:|
Mouse   322 LARKTEGYSGADISIIVRDSLMQPVRKVQSATHFKKVCGPSRTNPSVMIDDLLTPCSPGDPGAIE 386

  Fly   392 MNWMDVPSDKLFEPPVTMRDMLKSLSRTKPTVNEDDLKKLRKFTEDFGQE 441
            |.|||||.|||.||.|.|.|||:||:.|:||||.|||.|::||:||||||
Mouse   387 MTWMDVPGDKLLEPVVCMSDMLRSLATTRPTVNADDLLKVKKFSEDFGQE 436

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vps4	NP_573258.1	MIT_VPS4	6..69	CDD:239141	51/62 (82%)
		RecA-like_VPS4	126..296	CDD:410929	146/169 (86%)
		AAA_lid_3	323..361	CDD:465537	29/37 (78%)
		Vps4_C	379..439	CDD:462762	41/59 (69%)
Vps4a	NP_569053.1	PTZ00454	4..348	CDD:240423	268/350 (77%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	75..106		15/37 (41%)
		RecA-like_VPS4	121..291	CDD:410929	146/169 (86%)
		Vps4_C	374..434	CDD:462762	41/59 (69%)