DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Vps4 and vps4a

DIOPT Version :9

Sequence 1:	NP_001285396.1	Gene:	Vps4 / 32777	FlyBaseID:	FBgn0283469	Length:	442	Species:	Drosophila melanogaster
Sequence 2:	XP_002943933.1	Gene:	vps4a / 100158600	XenbaseID:	XB-GENE-970546	Length:	436	Species:	Xenopus tropicalis

Alignment Length:	441	Identity:	340/441 - (77%)
Similarity:	384/441 - (87%)	Gaps:	11/441 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 TTLQKAIDLVTKATEEDRNKNYAEALRLYEHGVEYFLHTIKYEAQGEKAKDSIRAKCLQYLDRAE 69
            :||||||||||||||||:||||.||||||:|.||||||.|||||..:|||:||||||:|||||||
Frog     4 STLQKAIDLVTKATEEDKNKNYEEALRLYQHAVEYFLHAIKYEAHSDKAKESIRAKCMQYLDRAE 68

  Fly    70 KLKEYLK---KGKKKPIKEGGESSAKDDKDKKSDSDDEDGDDPEKKKLQSKLEDAIVIEKPKVQW 131
            |||:|||   |..|||:||       ...:|.||||.| |::|||||||.:|..|||:|||.|:|
Frog    69 KLKDYLKTKDKQNKKPVKE-------SQNEKGSDSDSE-GENPEKKKLQEQLMGAIVMEKPNVRW 125

  Fly   132 SDVAGLDAAKEALKEAVILPIKFPQLFTGKRIPWKGILLFGPPGTGKSYLAKAVATEANRSTFFS 196
            :|||||:.||||||||||||||||.||||||.||:||||||||||||||||||||||||.|||||
Frog   126 NDVAGLEGAKEALKEAVILPIKFPHLFTGKRTPWRGILLFGPPGTGKSYLAKAVATEANNSTFFS 190

  Fly   197 VSSSDLMSKWLGESEKLVKNLFELARQHKPSIIFIDEIDSMCSARSDNENDSVRRIKTEFLVQMQ 261
            |||||||||||||||||||||||||||||||||||||:||:|.:|::||:::.||||||||||||
Frog   191 VSSSDLMSKWLGESEKLVKNLFELARQHKPSIIFIDEVDSLCGSRNENESEAARRIKTEFLVQMQ 255

  Fly   262 GVGNDTDGILVLGATNIPWVLDSAIRRRFEKRIYIPLPEAHARLVMFKIHLGNTTHVLTEQDLKE 326
            ||||:.|||||||||||||||||||||||||||||||||..||..||::|||||.|.|.|::::|
Frog   256 GVGNNNDGILVLGATNIPWVLDSAIRRRFEKRIYIPLPEEAARAQMFRLHLGNTPHSLGEENIRE 320

  Fly   327 LAGKTEGYSGADISIVVRDALMEPVRKVQTATHFKRVSGPSPTNHEEIVNDLLVPCSPGDQGAVE 391
            ||.||:|||||||||:||||||:||||||:|||||:|.|||.||...||:|||.||||||.||||
Frog   321 LAKKTDGYSGADISIIVRDALMQPVRKVQSATHFKKVRGPSRTNPGIIVDDLLTPCSPGDPGAVE 385

  Fly   392 MNWMDVPSDKLFEPPVTMRDMLKSLSRTKPTVNEDDLKKLRKFTEDFGQEG 442
            |.||:||||||.||.|.|.|||:||:.|:||||.|||.|::||||||||||
Frog   386 MTWMEVPSDKLQEPVVCMSDMLRSLATTRPTVNSDDLLKVKKFTEDFGQEG 436

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vps4	NP_001285396.1	MIT_VPS4	6..69	CDD:239141	52/62 (84%)
		RecA-like_VPS4	126..296	CDD:410929	148/169 (88%)
		AAA_lid_3	323..361	CDD:407720	29/37 (78%)
		Vps4_C	379..439	CDD:401324	43/59 (73%)
vps4a	XP_002943933.1	SpoVK	<6..347	CDD:223540	272/348 (78%)
vps4a	XP_002943933.1	Vps4_C	373..433	CDD:370443	43/59 (73%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	241	1.000	Domainoid score	I2209
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H69132
Inparanoid	1	1.050	673	1.000	Inparanoid score	I729
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D321685at33208
OrthoFinder	1	1.000	-	-		FOG0002106
OrthoInspector	1	1.000	-	-		otm48306
Panther	1	1.100	-	-	LDO	PTHR23074
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1655
SonicParanoid	1	1.000	-	-		X1557
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	9.190