DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6788 and TNR

DIOPT Version :9

Sequence 1:	NP_573254.1	Gene:	CG6788 / 32773	FlyBaseID:	FBgn0030880	Length:	358	Species:	Drosophila melanogaster
Sequence 2:	NP_003276.3	Gene:	TNR / 7143	HGNCID:	11953	Length:	1358	Species:	Homo sapiens

Alignment Length:	364	Identity:	109/364 - (29%)
Similarity:	168/364 - (46%)	Gaps:	70/364 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 ILSLSISTSLAN--DPQRSFDQNADNPCSAHRIWVWRPILDRFAKVNSSDELKNQVNAMSETIKD 75
            :.|.:|||:.:.  ||..:...:.....||  :..|:|         ...|::|.|.....|
Human  1028 LTSGTISTNFSTLLDPPANLTASEVTRQSA--LISWQP---------PRAEIENYVLTYKST--- 1078

  Fly    76 LQTRIGHKNELLLLQAGQIKDQSARLNVLIKNMKVLRSECLNAQAEIKSKDIQIQLSAAKIKQMS 140
                .|.:.||::    ..:|...||..|::|                 .|..:.|.||:....|
Human  1079 ----DGSRKELIV----DAEDTWIRLEGLLEN-----------------TDYTVLLQAAQDTTWS 1118

  Fly   141 NELVT------------QCSRQDTCPIDGKGGIYKLKI-----RELPAF-EAPCSSNGWLTIQKR 187
            :...|            |...|.....|...|:|.:.:     ::|..: :......||:..|:|
Human  1119 SITSTAFTTGGRVFPHPQDCAQHLMNGDTLSGVYPIFLNGELSQKLQVYCDMTTDGGGWIVFQRR 1183

  Fly   188 YDGAENFDRGWKDYKDGFGRVRGEFFIGLEKVHLMTRQRRHELYIKLGKIDG-TTSHAHYDNFEL 251
            .:|..:|.|.|.||:.|||.|..||::||:.:|.:|.|.|:||.:.:.  || ..:.|.||.|.:
Human  1184 QNGQTDFFRKWADYRVGFGNVEDEFWLGLDNIHRITSQGRYELRVDMR--DGQEAAFASYDRFSV 1246

  Fly   252 GGEIESYELKSLGRYNGTAGDSLRPHERQKFTTNDKDNDAYRFNCAADEYGGWWYYDCAKSMLNG 316
            ......|:|: :|.|||||||||..|:.:.|:|.|:|||....|||....|.|||.:|.::.|||
Human  1247 EDSRNLYKLR-IGSYNGTAGDSLSYHQGRPFSTEDRDNDVAVTNCAMSYKGAWWYKNCHRTNLNG 1310

  Fly   317 KFYKEGRSRNGKTNGILWGSWHNNDWTYSLTFVEMMIRP 355
            |:   |.||:  :.||.|..|..::  :|:.||||.:||
Human  1311 KY---GESRH--SQGINWYHWKGHE--FSIPFVEMKMRP 1342

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6788	NP_573254.1	FReD	160..356	CDD:238040	78/203 (38%)
TNR	NP_003276.3	EGF_2	<208..230	CDD:285248
		EGF_2	267..292	CDD:285248
		EGF_2	299..323	CDD:285248
		fn3	328..398	CDD:278470
		fn3	416..496	CDD:278470
		fn3	505..583	CDD:278470
		FN3	595..679	CDD:238020
		fn3	687..766	CDD:278470
		fn3	776..855	CDD:278470
		fn3	865..944	CDD:278470
		fn3	954..1026	CDD:278470
		FN3	1042..1127	CDD:238020	24/123 (20%)
		FReD	1133..1342	CDD:238040	79/218 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2579
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19143
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.910