DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6788 and Tnn

DIOPT Version :9

Sequence 1:	NP_573254.1	Gene:	CG6788 / 32773	FlyBaseID:	FBgn0030880	Length:	358	Species:	Drosophila melanogaster
Sequence 2:	NP_808507.2	Gene:	Tnn / 329278	MGIID:	2665790	Length:	1560	Species:	Mus musculus

Alignment Length:	364	Identity:	101/364 - (27%)
Similarity:	166/364 - (45%)	Gaps:	56/364 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 SFDQNAD-----NPCSAHRIWVWRPILDRFAKVNSSDELKNQVNAMSETIKDLQTR---IGHKNE 85
            |.||::.     .|...:.|.||       |:..:.:..|....|::|.......|   :.|...
Mouse  1194 SKDQSSTILTGLKPGMEYTIHVW-------AQKGARESKKADTKALTEIDPPRNLRPFGVTHSGG 1251

  Fly    86 LLLLQAGQIKDQSARLNVLIKNMKVLRSECLNAQAEIKSKDIQ------IQLSAAKIKQMSNELV 144
            :|.......:.....|.....|..|...|....|...:.:|::      :.|.|.|..|.|..:.
Mouse  1252 VLTWLPPSAQIDGYILTYQFPNGTVKEVELPRGQQRFELQDLEQGVTYPVSLVAFKGNQRSRTVS 1316

  Fly   145 T-------------QCS--RQDTCPIDGKGGIYKLKI-----RELPAF-EAPCSSNGWLTIQKRY 188
            |             .||  :|:|   :...|:|.:.:     |.:..: :......||:..|:|.
Mouse  1317 TTLSTVDARFPHPSDCSQVQQNT---NAASGLYTIYLNGDASRPMQVYCDMDTDGGGWIVFQRRN 1378

  Fly   189 DGAENFDRGWKDYKDGFGRVRGEFFIGLEKVHLMT--RQRRHELYIKLGKIDGTTSHAHYDNFEL 251
            .|..:|.:.|:.|.:|||....||::||:|:|.:|  ...|:|:...|...: .:::|.||.|::
Mouse  1379 TGQLDFFKRWRSYVEGFGDPMKEFWLGLDKLHNLTTGTTTRYEVRADLQTFN-ESAYAVYDFFQV 1442

  Fly   252 GGEIESYELKSLGRYNGTAGDSLRPHERQKFTTNDKDNDAYRFNCAADEYGGWWYYDCAKSMLNG 316
            ....|.|:| |:|:|.|||||:|..|...||||.|:|||....|||...:|||||.:|..:..||
Mouse  1443 ASSKERYKL-SVGKYRGTAGDALTYHNGWKFTTFDRDNDIALSNCALTHHGGWWYKNCHLANPNG 1506

  Fly   317 KFYKEGRSRNGKTNGILWGSWHNNDWTYSLTFVEMMIRP 355
            |:   |.:::  :.|:.|..|..::  :|:.:||:.|||
Mouse  1507 KY---GETKH--SEGVNWEPWKGHE--FSIPYVELKIRP 1538

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6788	NP_573254.1	FReD	160..356	CDD:238040	71/204 (35%)
Tnn	NP_808507.2	EGF_2	<142..166	CDD:285248
		EGF_2	169..197	CDD:285248
		EB	181..233	CDD:279949
		EGF_2	233..259	CDD:285248
		fn3	264..332	CDD:278470
		fn3	359..434	CDD:278470
		fn3	444..521	CDD:278470
		FN3	532..608	CDD:214495
		FN3	620..696	CDD:214495
		fn3	708..785	CDD:278470
		fn3	796..875	CDD:278470
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	868..888
		fn3	884..961	CDD:278470
		fn3	972..1049	CDD:278470
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1044..1063
		FN3	1060..1136	CDD:214495
		fn3	1148..1225	CDD:278470	8/37 (22%)
		fn3	1236..1313	CDD:278470	13/76 (17%)
		FReD	1327..1539	CDD:238040	75/224 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2579
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810