DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6788 and FGB

DIOPT Version :9

Sequence 1:	NP_573254.1	Gene:	CG6788 / 32773	FlyBaseID:	FBgn0030880	Length:	358	Species:	Drosophila melanogaster
Sequence 2:	NP_005132.2	Gene:	FGB / 2244	HGNCID:	3662	Length:	491	Species:	Homo sapiens

Alignment Length:	385	Identity:	106/385 - (27%)
Similarity:	172/385 - (44%)	Gaps:	95/385 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 RPILDRFAKVNSSDELKNQVNAMSET----------IKDL----QTRIGHKNELLLLQAGQIK-- 95
            |||.      ||.|||.|.|.|:|:|          :|||    |.::.....::...:.:::
Human   121 RPIR------NSVDELNNNVEAVSQTSSSSFQYMYLLKDLWQKRQKQVKDNENVVNEYSSELEKH 179

  Fly    96 ----DQSARLNVLIKNMKVLRSECLNAQAEIK--SKDIQIQLSAAKIKQMSNELVTQCSRQDTCP 154
                |::...|: ..|::||||...|.:::|:  ..|:..|:...:         |.|:.....|
Human   180 QLYIDETVNSNI-PTNLRVLRSILENLRSKIQKLESDVSAQMEYCR---------TPCTVSCNIP 234

  Fly   155 IDG---------KGG----IYKLK-IRELPAFEAPCSSN----GWLTIQKRYDGAENFDRGWKDY 201
            :..         |||    :|.:: ...:..:...|..|    ||..||.|.||:.:|.|.|..|
Human   235 VVSGKECEEIIRKGGETSEMYLIQPDSSVKPYRVYCDMNTENGGWTVIQNRQDGSVDFGRKWDPY 299

  Fly   202 KDGFGRVR------------GEFFIGLEKVHLMTRQRRHELYIKLGKIDGTTSHAHYDNFELGGE 254
            |.|||.|.            ||:::|.:|:..:||....||.|::....|....|||..|.:..|
Human   300 KQGFGNVATNTDGKNYCGLPGEYWLGNDKISQLTRMGPTELLIEMEDWKGDKVKAHYGGFTVQNE 364

  Fly   255 IESYELKSLGRYNGTAGDSLRP--------------HERQKFTTNDKDNDAY-----RFNCAADE 300
            ...|:: |:.:|.||||::|..              |....|:|.|:|||.:     |..|:.::
Human   365 ANKYQI-SVNKYRGTAGNALMDGASQLMGENRTMTIHNGMFFSTYDRDNDGWLTSDPRKQCSKED 428

  Fly   301 YGGWWYYDCAKSMLNGKFYKEGR-----SRNGKTNGILWGSWHNNDWTYSLTFVEMMIRP 355
            .|||||..|..:..||::|..|:     :::|..:|::|.:| ...| ||:..:.|.|||
Human   429 GGGWWYNRCHAANPNGRYYWGGQYTWDMAKHGTDDGVVWMNW-KGSW-YSMRKMSMKIRP 486

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6788	NP_573254.1	FReD	160..356	CDD:238040	73/241 (30%)
FGB	NP_005132.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	44..75
		Beta-chain polymerization, binding distal domain of another fibrin	45..47
		Fib_alpha	92..234	CDD:312286	30/128 (23%)
		FReD	237..486	CDD:294064	73/251 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2579
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	168	1.000	Inparanoid score	I4150
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X25
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.860