Protein Alignment mnb and YAK1

DIOPT Version :10

• Sequence 1: NP_728107.2
• Gene: mnb / 32771
• FlyBaseID: FBgn0259168
• Length: 1047
• Species: Drosophila melanogaster
• Sequence 2: NP_012394.1
• Gene: YAK1 / 853300
• SGDID: S000003677
• Length: 807
• Species: Saccharomyces cerevisiae
• Alignment Length: 846
• Identity: 221/846 - (26%)
• Similarity: 360/846 - (42%)
• Gaps: 219/846 - (25%)

  Fly    11 MNGGDPVDKATADWAPFVVGAAAGGSFSSSIITSSSSSL--------NHHPHNGHHNHHHPPHYI 67
            ||..:..|.::::       :....|.|.:::|.|.:|:        |.|...|..|    |.|:
Yeast     1 MNSSNNNDSSSSN-------SNMNNSLSPTLVTHSDASMGSGRASPDNSHMGRGIWN----PSYV 54

  Fly    68 NYLAQIGCQHRVRNWPTNGNQDQADDDDAGHQIISKFLPKSAWDTVLLDVKR----------DVD 122
            |..:|...|.:.:|     :..|........|..|:|...:.|:...:...:          |::
Yeast    55 NQGSQRSPQQQHQN-----HHQQQQQQQQQQQQNSQFCFVNPWNEEKVTNSQQNLVYPPQYDDLN 114

  Fly   123 EDGDRDRDRVDGNVLMVQGSSSSSSRMKAERALYY-TMSAYGSSGGSVDAAQGSGS--GGGRQRH 184
            .:...|..|...:.|:|     ..:|..|.....| :..||.||..|: |...||.  .|.:|:.
Yeast   115 SNESLDAYRRRKSSLVV-----PPARAPAPNPFQYDSYPAYTSSNTSL-AGNSSGQYPSGYQQQQ 173

  Fly   185 APLY-----------GRFV----DAEDLPATHRDVMHHHSS------------------------ 210
            ..:|           .|||    |.:|..........::||
Yeast   174 QQVYQQGAIHPSQFGSRFVPSLYDRQDFQRRQSLAATNYSSNFSSLNSNTNQGTNSIPVMSPYRR 238

  Fly   211 -----PSSS------------SEVRAMQARIPN------------------HFREPA-----SGP 235
                 ||:|            .||:..:..||.                  .||..:     ..|
Yeast   239 LSAYPPSTSPPLQPPFKQLRRDEVQGQKLSIPQMQLCNSKNDLQPVLNATPKFRRASLNSKTISP 303

  Fly   236 LRKLSVDLIKTYKHINE--VYYAKKKRRAQQTQGDDDSSNKKERKLYNDGYDDDNHDYI------ 292
            |..::..||.||...:.  .|...|..:...|:..:...        |:|:|:.|.|||
Yeast   304 LVSVTKSLITTYSLCSPEFTYQTSKNPKRVLTKPSEGKC--------NNGFDNINSDYILYVNDV 360

  Fly   293 --IKNGEKFLDRYEIDSLIGKGSFGQVVKAYDHEEQCHVAIKIIKNKKPFLNQAQIEVKLLEMMN 355
              ::...|:|    :..::|:|:||||||..:...:..:|:|::|::..:|.|:..|.|:||::|
Yeast   361 LGVEQNRKYL----VLDILGQGTFGQVVKCQNLLTKEILAVKVVKSRTEYLTQSITEAKILELLN 421

  Fly   356 -RADAENKYYIVKLKRHFMWRNHLCLVFELLSYNLYDLLRNTNFRGVSLNLTRKFAQQLCTALLF 419
             :.|..||::.:::...|:.:|||||||||||.|||:||:...|.|:|:.|.|.|..|:..:|..
Yeast   422 QKIDPTNKHHFLRMYDSFVHKNHLCLVFELLSNNLYELLKQNKFHGLSIQLIRTFTTQILDSLCV 486

  Fly   420 LSTPELNIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYHYIQSRFYRSPEVLLGIQYDL 484
            |.  |..:|||||||||||||.|.:..:||:||||||:..:.:|.||||||||:||::|||.|..
Yeast   487 LK--ESKLIHCDLKPENILLCAPDKPELKIIDFGSSCEEARTVYTYIQSRFYRAPEIILGIPYST 549

  Fly   485 AIDMWSLGCILVEMHTGEPLFSGCNEVDQMNKIVEVLGMPPKYLLDQAHKTRKFFDKIVADGS-- 547
            :|||||||||:.|:..|.|:|.|.:|.:|:.:|::.||.||.:::|....:.||..|:..:.|
Yeast   550 SIDMWSLGCIVAELFLGIPIFPGASEYNQLTRIIDTLGYPPSWMIDMGKNSGKFMKKLAPEESSS 614

  Fly   548 ----------------YVLKKNQNGRKYKPPGSRKLHDILGVETGGPGGRRLDEP------GHSV 590
                            |.:.:..:.:.:|   .|||.||:         |....|      ...:
Yeast   615 STQKHRMKTIEEFCREYNIVEKPSKQYFK---WRKLPDII---------RNYRYPKSIQNSQELI 667

  Fly   591 SDYLKFKDLILR----MLDFDPKTRVTPYYALQHNFFKRTA-------------------DEATN 632
            ...::.::.::.    :|:.:|..|.||..|:.|.|..:..                   |:|..
Yeast   668 DQEMQNRECLIHFLGGVLNLNPLERWTPQQAMLHPFITKQEFTGEWFPPGSSLPGPSEKHDDAKG 732

  Fly   633 TSGAGATANAGAGGSG-------SSGAGGSSGGGVGGGLGASNSSSGAVSSSSAA------APTA 684
            ......:||..:..:|       ||..||:....:|.......::||.:|::.|.      .||:
Yeast   733 QQSEYGSANDSSNNAGHNYVYNPSSATGGADSVDIGAISKRKENTSGDISNNFAVTHSVQEGPTS 797

  Fly   685 A 685
            |
Yeast   798 A 798

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mnb	NP_728107.2	PKc_DYRK1	289..628	CDD:271128	133/394 (34%)
YAK1	NP_012394.1	PKc_YAK1	369..704	CDD:271114	128/352 (36%)