DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mnb and DYRK2

DIOPT Version :9

Sequence 1:	NP_728107.2	Gene:	mnb / 32771	FlyBaseID:	FBgn0259168	Length:	1047	Species:	Drosophila melanogaster
Sequence 2:	NP_006473.2	Gene:	DYRK2 / 8445	HGNCID:	3093	Length:	601	Species:	Homo sapiens

Alignment Length:	699	Identity:	211/699 - (30%)
Similarity:	312/699 - (44%)	Gaps:	173/699 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 AAGGSFSSSIITSSSSSLNHHPHNGHHNHHHPPHYINYLAQIGCQHRVRNWPTNGNQDQADDDDA 96
            |:..:.::..|..|..::|.|.|.|.|.|          .||..|             |..:|::
Human    57 ASNAAAAAHTIGGSKHTMNDHLHVGSHAH----------GQIQVQ-------------QLFEDNS 98

  Fly    97 GHQIISKFLPKSAWDTVLLDV-KRDVDEDGDRDRDRVDGNVLMVQGSSSSSSRMKAERALYYTMS 160
            ..:.:....|..     |..| |..:....:|..|.:...    ||||:|...|:
Human    99 NKRTVLTTQPNG-----LTTVGKTGLPVVPERQLDSIHRR----QGSSTSLKSME---------- 144

  Fly   161 AYGSSGGSVDAAQGSGSGGGRQRHAPLYGRFVDAEDLPATHRDVMHHHSSPSSSSEVRAMQARIP 225
                             |.|:.:..|:            |....|..:           ||....
Human   145 -----------------GMGKVKATPM------------TPEQAMKQY-----------MQKLTA 169

  Fly   226 NHFREPASGPLRKLSVDLIKTYKHINEVYY--AKKKRRAQQTQGDDDSSNKKERKLYNDGYDDDN 288
            ....|..|.|                |:|:  ...|:|...|.|.:           |.|||||.
Human   170 FEHHEIFSYP----------------EIYFLGLNAKKRQGMTGGPN-----------NGGYDDDQ 207

  Fly   289 HDYIIKNGEKFLDRYEIDSLIGKGSFGQVVKAYDHEEQCHVAIKIIKNKKPFLNQAQIEVKLLEM 353
            ..|:....:....|||:..:|||||||||||||||:...|||:|:::|:|.|..||..|:::||.
Human   208 GSYVQVPHDHVAYRYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEH 272

  Fly   354 MNRADAENKYYIVKLKRHFMWRNHLCLVFELLSYNLYDLLRNTNFRGVSLNLTRKFAQQLCTALL 418
            :.:.|.:|...::.:..:|.:|||:|:.|||||.|||:|::...|:|.||.|.||||..:...|.
Human   273 LRKQDKDNTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLD 337

  Fly   419 FLSTPELNIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYHYIQSRFYRSPEVLLGIQYD 483
            .|.  :..|||||||||||||....||.||::||||||...||:|.||||||||:|||:||.:|.
Human   338 ALH--KNRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGARYG 400

  Fly   484 LAIDMWSLGCILVEMHTGEPLFSGCNEVDQMNKIVEVLGMPPKYLLDQAHKTRKFFDK------- 541
            :.||||||||||.|:.||.||..|.:|.||:..::|:||||.:.|||.:.:.:.|...
Human   401 MPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKLLDASKRAKNFVSSKGYPRYC 465

  Fly   542 ---IVADGSYVLK--KNQNGRKYKPPGSRKLHDILGVETGGPGGRRLDEPGHSVSDYLKFKDLIL 601
               .::|||.||.  :::.|:...||.||:..:.|         :..|:|        .|.|.:.
Human   466 TVTTLSDGSVVLNGGRSRRGKLRGPPESREWGNAL---------KGCDDP--------LFLDFLK 513

  Fly   602 RMLDFDPKTRVTPYYALQHNFFKRTADEATNTSGAGATANAGAGGSGSSGAGGSSGGGVGGGLGA 666
            :.|::||..|:||..||:|.:.:|...:...                          |....:..
Human   514 QCLEWDPAVRMTPGQALRHPWLRRRLPKPPT--------------------------GEKTSVKR 552

  Fly   667 SNSSSGAVSSSSAAAPTAATAAATAAGSSGSGSSVGGGSSAAQQQQAMP 715
            ...|:||::|.|...|.:::|:......:....:.|.    .||:..:|
Human   553 ITESTGAITSISKLPPPSSSASKLRTNLAQMTDANGN----IQQRTVLP 597

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mnb	NP_728107.2	PKc_DYRK1	289..628	CDD:271128	151/350 (43%)
mnb	NP_728107.2	S_TKc	303..623	CDD:214567	148/331 (45%)
DYRK2	NP_006473.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..24
		PKc_DYRK2_3	156..535	CDD:271126	168/435 (39%)
		Nuclear localization signal. /evidence=ECO:0000305\|PubMed:19965871	189..191		1/1 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162948at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R968
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.850