DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mnb and AT1G73460

DIOPT Version :9

Sequence 1:	NP_728107.2	Gene:	mnb / 32771	FlyBaseID:	FBgn0259168	Length:	1047	Species:	Drosophila melanogaster
Sequence 2:	NP_001319375.1	Gene:	AT1G73460 / 843681	AraportID:	AT1G73460	Length:	1169	Species:	Arabidopsis thaliana

Alignment Length:	634	Identity:	166/634 - (26%)
Similarity:	268/634 - (42%)	Gaps:	119/634 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 NGHHNHHHPPHYINYLAQIGCQH-RVRNWPTNGNQDQAD------DDDAGHQIISKFLPKSAWDT 112
            |.|...|....|:.     ..|| .||:.....|.|.||      |..||......|......|.
plant   575 NVHRKSHRDDVYVE-----DDQHDSVRSIGVGINSDAADFGSEVRDSLAGGSSEGDFEYSRDHDP 634

  Fly   113 VLLDVKR----------DVDEDGDRDRDRVDGNVLMVQGSSSSSSRMKAERALYYTMSAYGSSGG 167
            |....|:          |......:...:.||...:....||.|..:|.:....::..:....|.
plant   635 VASRFKQLYSESDKKHIDAPNKNKQQASKNDGPDYIADNDSSGSFHVKIQTDGGFSFGSSQKDGQ 699

  Fly   168 SVDAAQGSGSGGG------RQRHAPLYGRFVDAEDLPATHR----DVMHHHSS--PSSSSEVRAM 220
            |:.|........|      |.|:..........:|:.||.|    |....|||  .::::.::::
plant   700 SMHAESSKSLWSGNHETVTRDRNTERLSASTAMDDMVATWRRKSSDSSSSHSSVKDNNATSIKSL 764

  Fly   221 QARIPNHFREPASGPLRKLSVDLIKTYKHINEVYYAKKKRRAQQTQGDDDSS------------- 272
            .:       .|:|     ||....:..||.:     |:..|...::.:||::
plant   765 NS-------SPSS-----LSNYACEERKHAD-----KEDDRNDSSEIEDDNATALDDEEAVAVQE 812

  Fly   273 --------------------NKKERKLYNDGYDDDNHDYIIKNGEKFLDRYEIDSLIGKGSFGQV 317
                                ::|.|    .|::::.:..::.| .....||.:...:|..:|.:.
plant   813 QVRQIKAQEEEFETFDLKIVHRKNR----TGFEEEKNFNVVLN-SVIAGRYHVTEYLGSAAFSKA 872

  Fly   318 VKAYDHEEQCHVAIKIIKNKKPFLNQAQIEVKLLEMMNRADAENKYYIVKLKRHFMWRNHLCLVF 382
            ::|:|.:....|.||||||.|.|.:|:..|:|||:.:|:.|..:||::::|..:|.:|.||.:|.
plant   873 IQAHDLQTGMDVCIKIIKNNKDFFDQSLDEIKLLKYVNKHDPADKYHLLRLYDYFYYREHLLIVC 937

  Fly   383 ELLSYNLYDLLRNTNFRGVSLNLTRKFAQ----QLCTALLFLSTPELNIIHCDLKPENILLCNPK 443
            |||..|||:..:.....|..:..|....|    |...:|.||.  .|.:|||||||||||:.:..
plant   938 ELLKANLYEFHKFNRESGGEVYFTMPRLQSITIQCLESLQFLH--GLGLIHCDLKPENILVKSYS 1000

  Fly   444 RSAIKIVDFGSSCQLGQRIYHYIQSRFYRSPEVLLGIQYDLAIDMWSLGCILVEMHTGEPLFSGC 508
            |..||::|.||||.....:..|:|||.||:|||:||:.||..||:|||||||.|:.||..||...
plant  1001 RCEIKVIDLGSSCFETDHLCSYVQSRSYRAPEVILGLPYDKKIDVWSLGCILAELCTGNVLFQND 1065

  Fly   509 NEVDQMNKIVEVLGMPPKYLLDQAHKTRKFFDKIVADGSYVLKKNQ--NGRKYKPPGSRKLHDIL 571
            :....:.:::.::|.....:|.:...:.|:|.|    ...:.::||  |..:|..|....|...|
plant  1066 SPASLLARVMGIVGSFDNEMLTKGRDSHKYFTK----NRMLYERNQESNRLEYLIPKRTSLRHRL 1126

  Fly   572 GVETGGPGGRRLDEPGHSVSDYLKFKDLILRMLDFDPKTRVTPYYALQH 620
            .:...|                  |.|.:..:|:.:||.|.:...||:|
plant  1127 PMGDQG------------------FTDFVAHLLEINPKKRPSAAEALKH 1157

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mnb	NP_728107.2	PKc_DYRK1	289..628	CDD:271128	113/338 (33%)
mnb	NP_728107.2	S_TKc	303..623	CDD:214567	111/324 (34%)
AT1G73460	NP_001319375.1	PKc_DYRK_like	858..1160	CDD:271035	111/324 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	3	2.770