DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mnb and YAK1

DIOPT Version :9

Sequence 1:	NP_728107.2	Gene:	mnb / 32771	FlyBaseID:	FBgn0259168	Length:	1047	Species:	Drosophila melanogaster
Sequence 2:	NP_198447.2	Gene:	YAK1 / 833590	AraportID:	AT5G35980	Length:	956	Species:	Arabidopsis thaliana

Alignment Length:	1012	Identity:	267/1012 - (26%)
Similarity:	384/1012 - (37%)	Gaps:	358/1012 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   159 MSAYGSSGGSVDAAQGS-GSGGGRQRHAPLYGRFVDAEDLPATHRDVMHHHSSPSSSSEVRAMQA 222
            |....||.|:..|..|. ||.|......|:  :.|....||..           .|:|:|...
plant     1 MDDIDSSDGAAAARAGEIGSIGVSTPWKPI--QLVFKRYLPQN-----------GSASKVHVA-- 50

  Fly   223 RIPNHFREPASGPLRKLSVDLIKTYKHINEVYYAKKKRRAQQTQGDDDSSNKKERKLY------- 280
                 .::|.   :.:|:.||::|||..:..:    |.|.:...           |.|
plant    51 -----VKKPV---VVRLTRDLVETYKICDPQF----KYRGELNP-----------KRYLTTPSVG 92

  Fly   281 --NDGYDDDNHDYIIKNGEKFL-----DRYEIDSLIGKGSFGQVVKAYDHEEQCHVAIKIIKNKK 338
              |||:|:.|:|.|:...:.|.     .||.:..|:|.|:||||.|.:..|....||:|:|||:.
plant    93 VNNDGFDNVNYDLILAVNDDFCSSDSRQRYIVKDLLGHGTFGQVAKCWVPETNSFVAVKVIKNQL 157

  Fly   339 PFLNQAQIEVKLLEMMNRA-DAENKYYIVKLKRHFMWRNHLCLVFELLSYNLYDLLRNTNFRGVS 402
            .:..||.:||.:|..:|:. |.|:|.:||::..:|:.::|||:.||||..|||:|::...|||:|
plant   158 AYYQQALVEVSILTTLNKKYDPEDKNHIVRIYDYFLHQSHLCICFELLDMNLYELIKINQFRGLS 222

  Fly   403 LNLTRKFAQQLCTALLFLSTPELNIIHCDLKPENILLC-NPKRSAIKIVDFGSSCQLGQRIYHYI 466
            |::.:.|::|:...|..|.  :..|||||||||||||| :.|.:.|||:||||:|...:.:|.||
plant   223 LSIVKLFSKQILLGLALLK--DAGIIHCDLKPENILLCASVKPTEIKIIDFGSACMEDKTVYSYI 285

  Fly   467 QSRFYRSPEVLLGIQYDLAIDMWSLGCILVEMHTGEPLFSGCNEVDQMNKIVEVLG-MPPKYLLD 530
            |||:|||||||||.||..||||||.|||:.|:..|.|||.|.:|.|.:.:::|:|| .||.|:|.
plant   286 QSRYYRSPEVLLGYQYTTAIDMWSFGCIVAELFLGLPLFPGGSEFDILRRMIEILGKQPPDYVLK 350

  Fly   531 QAHKTRKFFDKIVAD-------GSY------------------VLKKNQNGRKYKPPGSRKLHDI 570
            :|..|.||| |.|..       |:|                  ..||.:.|::|.  ..:.|.:|
plant   351 EAKNTNKFF-KCVGSVHNLGNGGTYGGLKSAYMALTGEEFEAREKKKPEIGKEYF--NHKNLEEI 412

  Fly   571 LGVETGGPGGRRLDEPGHSVSDYLKFKDLILRMLD-------FDPKTRVTPYYALQHNFFKRTAD 628
            :   ...|....|.|     .|.:|...:.|.::|       |||..|.:|:.|.:|.|.  |.:
plant   413 V---KSYPYKINLPE-----DDVVKETQIRLALIDFLKGLMEFDPAKRWSPFQAAKHPFI--TGE 467

  Fly   629 EAT---------------------NTSGAGATANAG--------------------------AGG 646
            ..|                     :..|.|....||                          |..
plant   468 PFTCPYNPPPETPRVHVTQNIKVDHHPGEGHWFAAGLSPHVSGRTRIPMHNSPHFQMMPYSHANS 532

  Fly   647 SGSSGAGGS------------SGGGVGG-----------GLGASNSSSGAVSSSSAAAPTAATAA 688
            .||.|:.||            |.||.|.           ||...|....::..:|..|.......
plant   533 YGSIGSYGSYNDGTIQDNSYGSYGGTGNMFAYYSPVNHPGLYMQNQGGVSMLGTSPDARRRVMQY 597

  Fly   689 ATAAGSSGSGSSVGGGSSAAQQQQAMPLPLPLPLPLPP-----------LA------GPGGASDG 736
            ....|.:|.|:|...|:.|           ||||...|           ||      ||......
plant   598 PHGNGPNGLGTSPSAGNFA-----------PLPLGTSPSQFTPNTNNQFLAGSPGHHGPTSPVRN 651

  Fly   737 QCHGLLMHSVAA----------------------------NAMNNF------------------- 754
            .|||..:..:||                            :.|:||
plant   652 SCHGSPLGKMAAFSQINRRMSAGYSGGSQSQDSSLSQAQGHGMDNFYQNEGYSGQFSGSPSRRQL 716

  Fly   755 -------------------------SALSLQSNAHPPPSLANSHHSTNSLGSLNHISPG------ 788
                                     :..||:||.:.|.|.|  ||..|...:|:...||
plant   717 DSGVKNRKQTQGGTTLSTGYSTHNNANSSLRSNMYNPSSTA--HHLENPDTALSVPDPGDWDPNY 779

  Fly   789 --------------------STGCH-------------NNNSNSSNNNTRHSRLYGSNMV----- 815
                                |.|..             |:|:::|::|....|.|..|..
plant   780 SDDLLLEEDSADESSLANAFSRGMQLGSTDASSYSRRFNSNASTSSSNPTTQRRYAPNQAFSQVE 844

  Fly   816 ----------NMVGHHNSGSSN-NHNSISYPHAMECDPP---------------------QMPPP 848
                      ...|.|..||.. .|.|.:.|..:...||                     |:||.
plant   845 TGSPPSNDPHARFGQHIPGSQYIPHVSQNSPSRLGQQPPQRYNHGRPNAGRTMDRNHMNAQLPPS 909

  Fly   849 PPNGHGRMRVPAIMQLQPNSYAPNSVPYYGNMSSSSV 885
            ..|..|:.|.|     :.:||. |.|| :|..:::.|
plant   910 NTNSGGQQRSP-----RSSSYT-NGVP-WGRRTNNHV 939

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mnb	NP_728107.2	PKc_DYRK1	289..628	CDD:271128	147/378 (39%)
mnb	NP_728107.2	S_TKc	303..623	CDD:214567	141/354 (40%)
YAK1	NP_198447.2	PKc_YAK1	122..464	CDD:271114	141/354 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm3032
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1406
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	7	6.770