DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mnb and AT3G17750

DIOPT Version :9

Sequence 1:	NP_728107.2	Gene:	mnb / 32771	FlyBaseID:	FBgn0259168	Length:	1047	Species:	Drosophila melanogaster
Sequence 2:	NP_188402.1	Gene:	AT3G17750 / 821043	AraportID:	AT3G17750	Length:	1138	Species:	Arabidopsis thaliana

Alignment Length:	567	Identity:	167/567 - (29%)
Similarity:	261/567 - (46%)	Gaps:	81/567 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    91 ADDDDAGHQIISKFLP--KSAWDTVLLDVKRDVDEDGDRDRDRVDGNVLM---VQGSSSSSSRMK 150
            :||.|....||.::.|  .|.||..||.. |.|...|.:.......::|:   ..|..|..|.:
plant   604 SDDVDDNGSIIPEYFPGEGSEWDLELLPY-RGVGVAGVKPPPGKGASMLLKNFADGGFSFPSPV- 666

  Fly   151 AERALYYTMSAYGSSGGSVDAA------QGSG---------------SGGGRQRHAPLYGRFVDA 194
            |:|......||........||.      :..|               ||...:|:.    |.:|.
plant   667 ADRQKSQDDSANPEWSNHCDAVVRNESDEPKGLIQSDSMIVSSTKRCSGSSSERNL----RDMDD 727

  Fly   195 EDLPATHRDVMHHHSSPSSSSEVRAMQARIPNHFREPAS-GPLRKLSVDLIKTYKHINEVYYAKK 258
            |.:.::      .:||||:.|..............|..| ||    ..|...:::..:.:...::
plant   728 EKVASS------RNSSPSALSHSSDTGREHKEEDEEETSHGP----EEDPGTSFEDEDAIVVQEQ 782

  Fly   259 KRRAQQTQGDDDSSNKK--ERKLYNDGYDDDNHDYIIKNGEKFLDRYEIDSLIGKGSFGQVVKAY 321
            .|:.|..:.|.::.|.|  .|| ...|:::|.:.:::.| .....||.:...:|..:|.:.::|:
plant   783 VRQIQAQEQDFETFNLKIVHRK-NRTGFEEDKNFHVVLN-SVIAGRYHVTEHLGSAAFSKAIQAH 845

  Fly   322 DHEEQCHVAIKIIKNKKPFLNQAQIEVKLLEMMNRADAENKYYIVKLKRHFMWRNHLCLVFELLS 386
            |......|.:|||||.|.|.:|:..|:|||:.:|:.|..:||::::|..:|.:|.||.:|.|||.
plant   846 DLHTGIDVCVKIIKNNKDFFDQSLDEIKLLKYVNQHDPADKYHLLRLYDYFYFREHLLIVCELLK 910

  Fly   387 YNLYDLLRNTNFRGVSLNLTRKFAQ----QLCTALLFLSTPELNIIHCDLKPENILLCNPKRSAI 447
            .|||:..:.....|..:..|....|    |...||.||.  .|.:|||||||||||:.:..|..|
plant   911 ANLYEFQKFNRESGGEVYFTMPRLQSITIQCLEALNFLH--GLGLIHCDLKPENILIKSYSRCEI 973

  Fly   448 KIVDFGSSCQLGQRIYHYIQSRFYRSPEVLLGIQYDLAIDMWSLGCILVEMHTGEPLFSGCNEVD 512
            |::|.||||.....:..|:|||.||:|||:||:.||..||:|||||||.|:.||..||...:...
plant   974 KVIDLGSSCFETDHLCSYVQSRSYRAPEVILGLPYDKKIDIWSLGCILAELCTGNVLFQNDSPAT 1038

  Fly   513 QMNKIVEVLGMPPKYLLDQAHKTRKFFDKIVADGSYVLKKNQ--NGRKYKPPGSRKLHDILGVET 575
            .:.:::.::|...:.:|.:...|.|:|.|    ...:.::||  |..:|..|....|.
plant  1039 LLARVIGIIGSIDQEMLAKGRDTCKYFTK----NHLLYERNQESNNLEYLIPKKSSLR------- 1092

  Fly   576 GGPGGRRL--DEPGHSVSDYLKFKDLILRMLDFDPKTRVTPYYALQH 620
                 |||  .:.|        |.|.:..:|..|||.|.:.:.||:|
plant  1093 -----RRLPMGDQG--------FIDFVAYLLQVDPKKRPSAFEALKH 1126

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mnb	NP_728107.2	PKc_DYRK1	289..628	CDD:271128	117/340 (34%)
mnb	NP_728107.2	S_TKc	303..623	CDD:214567	115/326 (35%)
AT3G17750	NP_188402.1	PKc_DYRK_like	827..1129	CDD:271035	115/326 (35%)
AT3G17750	NP_188402.1	S_TKc	827..1129	CDD:214567	115/326 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	3	2.770