DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mnb and AT2G40120

DIOPT Version :9

Sequence 1:	NP_728107.2	Gene:	mnb / 32771	FlyBaseID:	FBgn0259168	Length:	1047	Species:	Drosophila melanogaster
Sequence 2:	NP_181541.1	Gene:	AT2G40120 / 818603	AraportID:	AT2G40120	Length:	570	Species:	Arabidopsis thaliana

Alignment Length:	593	Identity:	179/593 - (30%)
Similarity:	260/593 - (43%)	Gaps:	98/593 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 RNWPTNGNQDQADDDDAGHQIIS----KFLPKSAWDTVLLDVKRDVDEDGDRDRDRVDGNVLMVQ 140
            ||..|.......||.:..:::.|    |||........:....|..|..||
plant    14 RNGLTEAESALRDDINEKNKLASFDFEKFLFPIPTPIKITASSRPSDSGGD-------------- 64

  Fly   141 GSSSSSSRMKAE-RALYYTMSAYGSSGGSVDAAQGSGSGGGRQRHAPLYGRFVDAEDLPATHRDV 204
            ||:|.||....| .:|..:.|.:.||.|.|:....|.|....|      .:|..|...|......
plant    65 GSNSKSSSSDDEFVSLDSSTSGFCSSSGFVNPYGDSSSSSDGQ------SQFGTARTYPEWSEFY 123

  Fly   205 MHHHSS------------------PSSSSEVRAMQARIPN----HFREPASGPLRKLSVD-LIKT 246
            :|:.:.                  |.::.:......:..|    :.|..:.|.|.:.|:| |.|.
plant   124 LHNETEDEDEFMSPAFRESDCFILPENAEDKFITDNQFENSLGVYDRSSSQGSLTEASLDYLDKP 188

  Fly   247 YKHINEVYYAKKKRRAQQTQGDDDSSNKKERKLYN---DGYD---------------DDNHDYII 293
            :  :.::....|........||..:...:|..:.:   |.|:               ::|.|..|
plant   189 F--LLDIGLEDKTDELDLKTGDQLNVTDEEVDVVHEVEDEYEVFNLRIIHWKNRTGFEENKDLPI 251

  Fly   294 KNGEKFLDRYEIDSLIGKGSFGQVVKAYDHEEQCHVAIKIIKNKKPFLNQAQIEVKLLEMMNRAD 358
            ........||.|...||..:|.:||:|.|......|.:|||||.|.|.:|:..|:|||:.:|:.|
plant   252 VINTVIGGRYYITEYIGSAAFSKVVQAQDLHNGVDVCLKIIKNDKDFFDQSLDEIKLLKHVNKHD 316

  Fly   359 AENKYYIVKLKRHFMWRNHLCLVFELLSYNLYDLLRNTNFRGVS--LNLTR--KFAQQLCTALLF 419
            ..::::|::|..:|..:.||.:|.|||..|||:..:.....|..  .||:|  ...:|...||:|
plant   317 PADEHHILRLYDYFYHQEHLFIVCELLRANLYEFQKFNQESGGEPYFNLSRLQVITRQCLDALVF 381

  Fly   420 LSTPELNIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYHYIQSRFYRSPEVLLGIQYDL 484
            |.  .|.||||||||||||:.:.||.|:||:|.||||.....:..|:|||.||:|||:||:.||.
plant   382 LH--GLGIIHCDLKPENILIKSYKRCAVKIIDLGSSCFRSDNLCLYVQSRSYRAPEVILGLPYDE 444

  Fly   485 AIDMWSLGCILVEMHTGEPLFSGCNEVDQM--NKIVEVLGMPPKYLLDQAHKTRKFFDKIVADGS 547
            .||:|||||||.|:.:||.||.  ||...|  .:||.|||.....:|::..:|.|:|.|  ....
plant   445 KIDLWSLGCILAELCSGEVLFP--NEAVAMILARIVAVLGPIETEMLEKGQETHKYFTK--EYDL 505

  Fly   548 YVLKKNQNGRKYKPPGSRKLHDILGVETGGPGGRRLDEPGHSVSDYLKFKDLILRMLDFDPKTRV 612
            |.|.:..|..:|.......|.:.|                 .|||.| |.|.:..:||.:|..|.
plant   506 YHLNEESNEIEYIITEESSLEEQL-----------------QVSDEL-FLDFVRTLLDINPLRRP 552

  Fly   613 TPYYALQH 620
            |...||.|
plant   553 TALEALNH 560

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mnb	NP_728107.2	PKc_DYRK1	289..628	CDD:271128	131/338 (39%)
mnb	NP_728107.2	S_TKc	303..623	CDD:214567	128/324 (40%)
AT2G40120	NP_181541.1	PKc_DYRK_like	261..563	CDD:271035	128/324 (40%)
AT2G40120	NP_181541.1	S_TKc	261..563	CDD:214567	128/324 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	3	2.770