Protein Alignment mnb and hipk2

DIOPT Version :10

• Sequence 1: NP_728107.2
• Gene: mnb / 32771
• FlyBaseID: FBgn0259168
• Length: 1047
• Species: Drosophila melanogaster
• Sequence 2: NP_001072750.1
• Gene: hipk2 / 780207
• XenbaseID: XB-GENE-958494
• Length: 1142
• Species: Xenopus tropicalis
• Alignment Length: 1120
• Identity: 273/1120 - (24%)
• Similarity: 410/1120 - (36%)
• Gaps: 309/1120 - (27%)

  Fly   150 KAERALYYTMSAYGSSGGSVDAAQGSG-SGGGRQRHAPLYGRFVDAEDLPATHRDVMHHHSSPSS 213
            |.|.:..:.|:.||......::.:.|. ||.....||.|...:......|.:...::...||..|
 Frog    25 KLELSPGWDMTGYGCHSKVYNSGKNSSTSGQPVLSHASLLQSYEQTVIFPTSAGHIVVTSSSNGS 89

  Fly   214 SSEV-RAMQARIPNHFREPASGPLRKLSVDLIKTYKHINEVYYAKKKRRAQQTQGDDD------- 270
            |:.. :|:..        |.:..:|:.:|.|:.||:...      .||:.::.:.:..
 Frog    90 SAATGQALGG--------PQTNLMRRSTVSLLDTYQKCG------LKRKCEELENNSSVQIVDEH 140

  Fly   271 ------------SSNKKERKLYNDGYDDDNHDYIIKNGE---KFLDRYEIDSLIGKGSFGQVVKA 320
                        ::........|.|.:.:. ||.:...|   ...:.||:...:|:|:||||||.
 Frog   141 PPVTQNNASGATAATTSTATSKNSGSNSEG-DYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKC 204

  Fly   321 YDHEEQCHVAIKIIKNKKPFLNQAQIEVKLLEMMNRADAENKYYIVKLKRHFMWRNHLCLVFELL 385
            :.......|||||:||...:..|.||||.:|..::...|:: |..|:....|..:||.|||||:|
 Frog   205 WKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTESADD-YNFVRAYECFQHKNHTCLVFEML 268

  Fly   386 SYNLYDLLRNTNFRGVSLNLTRKFAQQLCTALLFLSTPELNIIHCDLKPENILLCNPKRS--AIK 448
            ..||||.|:...|..:.|...|...||:.|||:.|.:  |.:||.|||||||:|.:|.|.  .:|
 Frog   269 EQNLYDFLKQNKFSPLPLKYIRPVLQQVGTALMKLKS--LGLIHADLKPENIMLVDPSRQPYRVK 331

  Fly   449 IVDFGSSCQLGQRIYH-YIQSRFYRSPEVLLGIQYDLAIDMWSLGCILVEMHTGEPLFSGCNEVD 512
            ::||||:..:.:.:.. |:|||:||:||::||:.:..|||||||||::.|:..|.||:.|.:|.|
 Frog   332 VIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYD 396

  Fly   513 QMNKIVEVLGMPPKYLLDQAHKTRKFFDKIVADGSYVL--------KKNQNGRKYKPPGSRK--- 566
            |:..|.:..|:|.:|||....||.:||:: ..|..|.|        .:|:.|.|.|.  :||
 Frog   397 QIRYISQTQGLPAEYLLSSGTKTTRFFNR-DGDSPYPLWRLKTPEDHENETGIKSKE--ARKYIF 458

  Fly   567 --LHDILGVETGG--PGGRRLDEPGHSVSDYLKFKDLILRMLDFDPKTRVTPYYALQHNFF---- 623
              |.|:..|....  .|...|.|.    :|..:|.||:.:||..|...|:||...|.|.|.
 Frog   459 NCLDDMAQVNMASDLEGSDMLVEK----ADRREFIDLLKKMLTIDADKRITPIETLNHPFVTMTH 519

  Fly   624 --------------------KRTAD--EATNTSGAGATANAGAGGSGSSGAGGSSGGGVGGGLGA 666
                                ||..:  :..|.|......:.....|.:.....|:      .|..
 Frog   520 LLDFPHSSHVKSCFQNMEICKRRVNMYDTVNHSKTPFITHVAPSTSTNLTMTFSN------QLNT 578

  Fly   667 SNSSSGAVSSSSAAAPTAATAAATA--------------------AGSSGSGSSVGG-------- 703
            .:|...|.|.::.|..|......||                    .|...|.|..||
 Frog   579 VHSQPTAASMAAVAQRTMPLQTGTAQLCARPDPFQQALIVCPPAFQGLQTSPSKHGGYSVRMENT 643

  Fly   704 --------GSSAAQ------QQQAMPLPLPLPLPLPP----LAGPGGASDGQCHGLLMH-SVAAN 749
                    |:.|.|      .|||.|......| |||    |||..      .|..:.| :|..:
 Frog   644 VPLVTQTAGAQALQIQPGLLTQQAWPSGTQQIL-LPPAWQQLAGVA------AHTSVQHATVIPD 701

  Fly   750 AMNNFSALSLQSNAH----------PPPSLANSHHSTNSLGSLN----HI---SPGSTGCHNNNS 797
            .|.....|:...|.|          ..|:|...|.:..|...||    |:   .|.|       |
 Frog   702 GMAGTQQLADWRNTHAHGTHYNPIMQQPALLTGHVTLPSAQPLNVGVAHVMRQQPTS-------S 759

  Fly   798 NSSNNNTRHSRLYGSNMVNMVGHHNSGSSNNHNSISYPHAMECDPPQMPPPPPN----------- 851
            :||:....||      :...:..:...||.:.||......::.:.|.....|.|
 Frog   760 SSSSRKKHHS------LARNISAYEVTSSQSVNSPQRSKRVKENTPPRCAVPQNTTACVPSITCG 818

  Fly   852 --------GHGRMR---------VPAIMQLQPNS----------YAPNSVPYYGNM--------S 881
                    .|.|.|         .||:..:..:|          .||:......|:        |
 Frog   819 WGDSAVGGSHNRQRQTIVIPDTPSPAVSVITISSDTDEEEEQKHVAPSLPKQRRNVISCVTVHDS 883

  Fly   882 SSSVAAAAAAAAAAASHLMMTDSSVISASAAGGGQGGGNP--------------------GQNPV 926
            ..|.:::..:..||:.|....::|...:....|.....||                    .:.|.
 Frog   884 PISDSSSNTSPYAASGHRRGNNTSAAESKCQTGNPCPANPRTIIVPPLKTQPSEGRLECERKQPD 948

  Fly   927 TPS------------AAAFLFPSQPAGTLY--GTALG-SLSDLPLPM------------------ 958
            |.|            |:|....:..|||.|  ..|.| |....||.:
 Frog   949 TTSHHMYKAKLLSSVASASHSSASSAGTAYRHSRAPGHSFQQQPLNLSQVSQHISTERTGSHRRQ 1013

  Fly   959 -----PLPMSVPLQLPPSSSSS-------------------VSSGSASVGSGGVGVGVV---GQR 996
                 |.....|...|.||.|.                   ..:..|::||.|....:|   |..
 Frog  1014 HAYIAPTLAQAPYSFPHSSPSHGAVHPHLAAAHLPSQPHLYTYTAPAALGSSGTVAHLVASQGSA 1078

  Fly   997 RHITGPAAQVGISQS 1011
            ||...||:.|.:|.:
 Frog  1079 RHAAYPASIVPVSMA 1093

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mnb	NP_728107.2	PKc_DYRK1	289..628	CDD:271128	137/383 (36%)
hipk2	NP_001072750.1	STKc_HIPK2	171..525	CDD:271129	135/363 (37%)