Protein Alignment mnb and dyrk1a

DIOPT Version :9

• Sequence 1: NP_728107.2
• Gene: mnb / 32771
• FlyBaseID: FBgn0259168
• Length: 1047
• Species: Drosophila melanogaster
• Sequence 2: XP_012812685.1
• Gene: dyrk1a / 779733
• XenbaseID: XB-GENE-1017105
• Length: 771
• Species: Xenopus tropicalis
• Alignment Length: 851
• Identity: 428/851 - (50%)
• Similarity: 510/851 - (59%)
• Gaps: 199/851 - (23%)

  Fly   221 QARIPNHFREPASGPLRKLSVDLIKTYKHINEVYYAKKKRRAQQTQGDDDSSNKKERKLYNDGYD 285
            |.|:|..||:||:.|||||||||||||||||||||||||||.||.|| ||||:|||||:||||||
 Frog    90 QRRMPQTFRDPATAPLRKLSVDLIKTYKHINEVYYAKKKRRHQQGQG-DDSSHKKERKVYNDGYD 153

  Fly   286 DDNHDYIIKNGEKFLDRYEIDSLIGKGSFGQVVKAYDHEEQCHVAIKIIKNKKPFLNQAQIEVKL 350
            |||:|||:|||||::||||||||||||||||||||||..||..||||||||||.|||||||||:|
 Frog   154 DDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRAEQEWVAIKIIKNKKAFLNQAQIEVRL 218

  Fly   351 LEMMNRADAENKYYIVKLKRHFMWRNHLCLVFELLSYNLYDLLRNTNFRGVSLNLTRKFAQQLCT 415
            ||:||:.|.|.|||||.||||||:|||||||||:||||||||||||||||||||||||||||:||
 Frog   219 LELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCT 283

  Fly   416 ALLFLSTPELNIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYHYIQSRFYRSPEVLLGI 480
            |||||:||||:|||||||||||||||||||||||||||||||||||||.|||||||||||||||:
 Frog   284 ALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGM 348

  Fly   481 QYDLAIDMWSLGCILVEMHTGEPLFSGCNEVDQMNKIVEVLGMPPKYLLDQAHKTRKFFDKIVAD 545
            .||||||||||||||||||||||||||.||||||:|||||||:||.::||||.|.||||:| :.:
 Frog   349 PYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMSKIVEVLGIPPAHILDQAPKARKFFEK-MPE 412

  Fly   546 GSYVLKKNQNGRK-YKPPGSRKLHDILGVETGGPGGRRLDEPGHSVSDYLKFKDLILRMLDFDPK 609
            |::.|||.::|:| |||||:||||::||||||||||||..|.||:|:||||||||||||||:|.|
 Frog   413 GTWNLKKTKDGKKEYKPPGTRKLHNLLGVETGGPGGRRGGESGHTVADYLKFKDLILRMLDYDAK 477

  Fly   610 TRVTPYYALQHNFFKRTADEATNTSGAGATA-------NAGAGGSGSSGAGGSSGGGVGGGLGAS 667
            ||:.|||||||:|||:||||.||||.:.:|:       ::|...|.||.:|||||
 Frog   478 TRIQPYYALQHSFFKKTADEGTNTSNSVSTSPAMEQSQSSGTTSSTSSSSGGSSG---------- 532

  Fly   668 NSSSGAVSSSSAAAPTAA--------TAAATAAGSSGSGSSVGGGSSAAQQQQAMP------LPL 718
            .|:||...|.    ||..        |||..|.........|        :||..|      .|.
 Frog   533 TSNSGRARSD----PTHQHRHSGGHFTAAVQAMDCETHSPQV--------RQQFPPGWTVPEAPT 585

  Fly   719 PLPLPLPPLAGPGGASDGQCHGLLMHSVAANAMNNFSALSLQSNAHPPPSLAN-SHHSTNSLGSL 782
            .:.:...|:.                               ::..|.|||..| .||..|  ||.
 Frog   586 QVTIETHPVQ-------------------------------ETTFHVPPSQQNVPHHHGN--GSH 617

  Fly   783 NHISPGSTGCHNNNSNSSNNNTRHSRLYGSNMVNMVGHHNSGSSNNHNSISYPHAMECDPPQMPP 847
            :|.....   |::..:..:|.|| :|:|.|         .|.||:..:|:...|:
 Frog   618 HHHHHHH---HHHGQHVLSNRTR-TRIYNS---------PSTSSSTQDSMDVGHS---------- 659

  Fly   848 PPPNGHGRMRVPAIMQLQPNSYAPNSVPYYGNMSSSSVAAAAAAAAAAASHLMMTDSSVISASAA 912
                 |..|.                     ::|||:.:::.::::..........:..::|:..
 Frog   660 -----HHSMT---------------------SLSSSTTSSSTSSSSTGNQGNQAYQNRPVAANTL 698

  Fly   913 GGGQGGGNPGQNPVTPSAAAFLFPSQPAGTLYGTALGSLSDLPLPMPLPMSVPLQLPPSSSSSVS 977
            ..||.|      .:..:..||..|.|..|
 Frog   699 DFGQNG------TMDVNLTAFSNPRQETG------------------------------------ 721

  Fly   978 SGSASVGSGGVGVGVVGQRRHITG-PAAQVGISQSVGSG---SSGSATGASSSDASSSSPMVGVC 1038
                                 ||| |..|  .|.:.|.|   :.|..|.....| ...|||.|||
 Frog   722 ---------------------ITGHPDYQ--YSANTGPGHYVTEGHLTMRQGMD-REDSPMTGVC 762

  Fly  1039 VQQNPV 1044
            |||:||
 Frog   763 VQQSPV 768

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mnb	NP_728107.2	PKc_DYRK1	289..628	CDD:271128	280/339 (83%)
		S_TKc	303..623	CDD:214567	266/320 (83%)
dyrk1a	XP_012812685.1	PKc_DYRK1	160..496	CDD:271128	278/336 (83%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	551	1.000	Domainoid score	I248
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	730	1.000	Inparanoid score	I611
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002707
OrthoInspector	1	1.000	-	-		otm48465
Panther	1	1.100	-	-	O	PTHR24058
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R968
SonicParanoid	1	1.000	-	-		X1406
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	9.090