Protein Alignment mnb and hipk1

DIOPT Version :10

• Sequence 1: NP_728107.2
• Gene: mnb / 32771
• FlyBaseID: FBgn0259168
• Length: 1047
• Species: Drosophila melanogaster
• Sequence 2: XP_012819927.1
• Gene: hipk1 / 734033
• XenbaseID: XB-GENE-987412
• Length: 1218
• Species: Xenopus tropicalis
• Alignment Length: 1148
• Identity: 276/1148 - (24%)
• Similarity: 432/1148 - (37%)
• Gaps: 325/1148 - (28%)

  Fly   104 FLPKSAWDTVLLDVKRDVDEDGDRDRDRVDGNVLMVQGSSSSSSRMKAERALYYTMSAYGSSGGS 168
            |.|.|...:.....|:...|....|   |.|     ||||:.          |||.:.      :
 Frog     8 FSPSSVSSSAFCSAKKLKVEPSGWD---VTG-----QGSSNK----------YYTHTK------N 48

  Fly   169 VDAAQGSGSGGGRQRHAPLYGRFVDAEDLPATHRDVMHHHSSPSSSSEVRAMQARIPNHFREPAS 233
            :..|||..|...:          |....|||...:::    .|::::|...:.|.     ....|
 Frog    49 LPVAQGHASSSHQ----------VAGFSLPAYEPNLL----IPAAAAEHIVVTAA-----DSTDS 94

  Fly   234 GPLRKLSVDLIKTYKH----INEVYYAKKKRRAQQTQGDDDSSNKKER---KLYN---------- 281
            ||........|.|::.    ::.......||::::...:.......||   .|.|
 Frog    95 GPTTSFQNSQILTHRSNVPLLDPYQKCGLKRKSEEVDSNGSVQIIDERPPLMLQNRTVVGAAATT 159

  Fly   282 ------DGYDDDNHDYIIKNGE---KFLDRYEIDSLIGKGSFGQVVKAYDHEEQCHVAIKIIKNK 337
                  ....:...||.:...|   ...:.||:...:|:|:||||.|.:....:..|||||:||.
 Frog   160 TTVTTKSSSSNGEGDYQLVQHEILCSMTNSYEVLEFLGRGTFGQVAKCWKRSTKEIVAIKILKNH 224

  Fly   338 KPFLNQAQIEVKLLEMMNRADAENKYYIVKLKRHFMWRNHLCLVFELLSYNLYDLLRNTNFRGVS 402
            ..:..|.||||.:|..::..:|: :|..|:....|..:||.|||||:|..||||.|:...|..:.
 Frog   225 PSYARQGQIEVSILSRLSSENAD-EYNFVRSYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLP 288

  Fly   403 LNLTRKFAQQLCTALLFLSTPELNIIHCDLKPENILLCNPKRS--AIKIVDFGSSCQLGQRIYH- 464
            |...|...||:.|||:.|.:  |.:||.|||||||:|.:|.|.  .:|::||||:..:.:.:..
 Frog   289 LKYIRPILQQVATALMKLKS--LGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKAVCST 351

  Fly   465 YIQSRFYRSPEVLLGIQYDLAIDMWSLGCILVEMHTGEPLFSGCNEVDQMNKIVEVLGMPPKYLL 529
            |:|||:||:||::||:.:..|||||||||::.|:..|.||:.|.:|.||:..|.:..|:|.:|||
 Frog   352 YLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLL 416

  Fly   530 DQAHKTRKFFD----------KIVADGSYVLK---KNQNGRKYKPPGSRKLHDI--LGVETGGPG 579
            ....||.:||:          ::.|...:.::   |::..|||.   ...|.|:  :.:.|...|
 Frog   417 SAGTKTSRFFNRDPDLGYPLWRLKAPDEHEMETGIKSKEARKYI---FNCLDDMAQVNMSTDLEG 478

  Fly   580 GRRLDEPGHSVSDYLKFKDLILRMLDFDPKTRVTPYYALQHNFF--------------------- 623
            ...|.|.    :|..::.||:.:||..|...|:||...|.|.|.
 Frog   479 TDMLAEK----ADRREYIDLLKKMLTIDADKRITPLKTLNHPFVTMTHLLDFPHSNHVKSCFQNM 539

  Fly   624 ---KR---------------TADEATNTS---------GAGATANAGAGGSGSSGAGGSSGGGVG 661
               ||               |...|.|||         ...:..|..:..:.||.|..:
 Frog   540 EICKRRSNMYDTVNQIKSPFTTHVAPNTSTNLTMSFNNQLNSVHNQASVLASSSTAAAT------ 598

  Fly   662 GGLGASNSSSGAVSSSSAAAPTAA--------------------------------------TAA 688
              |..:||....::..||..|.||                                      .||
 Frog   599 --LSLANSDVSLLNYQSALYPPAAGPVTGVTQQSVSLQPGTTQLCTQTDPFQQTFIVCPPAFQAA 661

  Fly   689 ATAAGSSGSGSSVGGGSS--------AAQ------------------------------QQQAMP 715
            ...|.:..||..|...:|        |||                              .|.|:|
 Frog   662 GLQATTKHSGFPVRMDNSVPIVPQAPAAQPLQIQSGVLTQGSCTPLMVATLHPHVATITPQYAVP 726

  Fly   716 LPLPLPLPLPPL---------AGPGGASD-------GQCHGLLMH-SVAANAM-----NNFSALS 758
            ..|......|.|         |.|||...       .|..|:.:| ||...||     .|...|:
 Frog   727 FTLNCAAGRPALVEQTAAVLQAWPGGTQQILLPSTWQQLPGVALHNSVQPTAMIPETIGNNQQLT 791

  Fly   759 LQSNAHPPPSLANSHHSTNSLGSL--NHIS-----PGSTGC-------HNNNSNSSNNNTRHSR- 808
            ...|||   |..|.:.:.....||  ||::     |.:.|.       .|:|:::..|..:.|:
 Frog   792 DWRNAH---SHGNQYSTLMQQPSLLANHVTLAAAQPLNVGVAHVVRQQQNSNTSTKKNKQQASQS 853

  Fly   809 ---------LYGSNMVNMVGHHNSGSSNNHNSISYPHAMECDP---PQMPPPPPNGHGRMRVPAI 861
                     :..|.:.::||.....:|:::|.: .|...:..|   |..|.||      :.|..|
 Frog   854 SSKALSSLDVIPSQVYSLVGSSPLQASSSYNPL-LPLQEQRQPIVIPDTPSPP------VSVITI 911

  Fly   862 M----QLQPNSYAP-NSVPYYGNMSSSSVAAAAAAAAAAASHLMMTDSSVISASAAGGGQGGGNP 921
            .    :.:.:.|.| ||    |....|:|          .|::.:.||....:|.:.......:.
 Frog   912 RSDTDEEEDSKYKPTNS----GMKLRSNV----------ISYVTVNDSPDSDSSVSSPYLADRHT 962

  Fly   922 GQNPVTPSAAAFLFPSQPAGTLYGTALGSLSDLPLPMPLPMS-VPLQLPPSSSSSVSSGSASV-- 983
            ..|.||.     :|....:.|.:..:|.|.:.:..|:...|: .||.   :..:.|.||:|.:
 Frog   963 SVNGVTG-----VFDMSNSRTAHSQSLNSRTIIVPPLKSQMNDCPLD---TQLTGVLSGAAKITK 1019

  Fly   984 ------GSGGVGVGVVGQRRH-ITGPAAQVGISQSVGSGSSGS 1019
                  |.....:...|.|.| :......:.:||:..|...|:
 Frog  1020 SCTATNGQSSSCITQTGCRSHRMLNGVQPLNLSQNQQSAMMGT 1062

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mnb	NP_728107.2	PKc_DYRK1	289..628	CDD:271128	132/398 (33%)
hipk1	XP_012819927.1	STKc_HIPK1	174..528	CDD:271130	129/363 (36%)