Protein Alignment mnb and Dyrk2

DIOPT Version :10

• Sequence 1: NP_728107.2
• Gene: mnb / 32771
• FlyBaseID: FBgn0259168
• Length: 1047
• Species: Drosophila melanogaster
• Sequence 2: XP_006514109.3
• Gene: Dyrk2 / 69181
• MGIID: 1330301
• Length: 665
• Species: Mus musculus
• Alignment Length: 544
• Identity: 185/544 - (34%)
• Similarity: 280/544 - (51%)
• Gaps: 90/544 - (16%)

  Fly   197 LPAT-HRDVMHHHSSPSSSSEVRAMQARIPNHFREPASGPL-----RKLSVDLIKTYKH-----I 250
            ||.. .|.:...|....||:.:::|:.     ..:..:.|:     .|..:..:..::|     .
Mouse   183 LPGVPERQLESIHRRQGSSTSLKSMEG-----MGKVKASPMTPEQAMKQYMQKLTAFEHHEIFSY 242

  Fly   251 NEVYY--AKKKRRAQQTQGDDDSSNKKERKLYNDGYDDDNHDYIIKNGEKFLDRYEIDSLIGKGS 313
            .|:|:  ...|:|...|.|.:           |.|||||...|:....:....|||:..:|||||
Mouse   243 PEIYFLGPNAKKRQGMTGGPN-----------NGGYDDDQGSYVQVPHDHVAYRYEVLKVIGKGS 296

  Fly   314 FGQVVKAYDHEEQCHVAIKIIKNKKPFLNQAQIEVKLLEMMNRADAENKYYIVKLKRHFMWRNHL 378
            ||||||||||:...|||:|:::|:|.|..||..|:::||.:.:.|.:|...::.:..:|.:|||:
Mouse   297 FGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDNTMNVIHMLENFTFRNHI 361

  Fly   379 CLVFELLSYNLYDLLRNTNFRGVSLNLTRKFAQQLCTALLFLSTPELNIIHCDLKPENILLCNPK 443
            |:.|||||.|||:|::...|:|.||.|.||||..:...|..|.  :..|||||||||||||....
Mouse   362 CMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALH--KNRIIHCDLKPENILLKQQG 424

  Fly   444 RSAIKIVDFGSSCQLGQRIYHYIQSRFYRSPEVLLGIQYDLAIDMWSLGCILVEMHTGEPLFSGC 508
            ||:||::||||||...||:|.||||||||:|||:||.:|.:.||||||||||.|:.||.||..|.
Mouse   425 RSSIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGE 489

  Fly   509 NEVDQMNKIVEVLGMPPKYLLDQAHKTRKFFDK----------IVADGSYVLK--KNQNGRKYKP 561
            :|.||:..::|:||||.:.|||.:.:.:.|...          .::|||.||.  :::.|:...|
Mouse   490 DEGDQLACMIELLGMPSQKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGP 554

  Fly   562 PGSRKLHDILGVETGGPGGRRLDEPGHSVSDYLKFKDLILRMLDFDPKTRVTPYYALQHNFFKRT 626
            |.||:..:.|         :..|:|        .|.|.:.:.|::||..|:||..||:|.:.:|.
Mouse   555 PESREWGNAL---------KGCDDP--------LFLDFLKQCLEWDPAVRMTPGQALRHPWLRRR 602

  Fly   627 ADEATNTSGAGATANAGAGGSGSSGAGGSSGGGVGGGLGASNSSSGAVSSSSAAAPTAATAAATA 691
            ..:...                          |....:.....|:||::|.|...|.:::|:...
Mouse   603 LPKPPT--------------------------GEKTAVKRVTESTGAITSISKLPPPSSSASKLR 641

  Fly   692 AGSSGSGSSVGGGSSAAQQQQAMP 715
            ...:....:.|.    .||:..:|
Mouse   642 TNLAQMTDANGN----IQQRTVLP 661

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mnb	NP_728107.2	PKc_DYRK1	289..628	CDD:271128	151/350 (43%)
Dyrk2	XP_006514109.3	PKc_DYRK2_3	220..599	CDD:271126	164/408 (40%)