Protein Alignment mnb and CLK4

DIOPT Version :9

• Sequence 1: NP_728107.2
• Gene: mnb / 32771
• FlyBaseID: FBgn0259168
• Length: 1047
• Species: Drosophila melanogaster
• Sequence 2: NP_065717.1
• Gene: CLK4 / 57396
• HGNCID: 13659
• Length: 481
• Species: Homo sapiens
• Alignment Length: 473
• Identity: 133/473 - (28%)
• Similarity: 221/473 - (46%)
• Gaps: 87/473 - (18%)

  Fly   201 HRDVMHHHSSPSSSS---EVRAMQAR-------------------IPNHF-REPASGPLRKLSVD 242
            :|....||....|..   |.|::..|                   :|.|: |:..||.....|..
Human    40 NRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKS 104

  Fly   243 LIKTYKHINEVYYAKKKRRAQQTQGDDDSSNKKERKLYNDGYDDDNHDYII-KNGEKFLDRYEID 306
            .:::.:       :..||:..:......|.:|..|:..:...:||...::| ::|:....||||.
Human   105 SVRSRR-------SSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIV 162

  Fly   307 SLIGKGSFGQVVKAYDH-EEQCHVAIKIIKNKKPFLNQAQIEVKLLEMMNRADAENKYYIVKLKR 370
            ..:|:|:||:||:..|| .:..|||:||:||...:...|:.|:::||.:|..|..:.:..|::..
Human   163 DTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLE 227

  Fly   371 HFMWRNHLCLVFELLSYNLYDLLRNTNFRGVSLNLTRKFAQQLCTALLFLSTPELNIIHCDLKPE 435
            .|....|:|:|||||..:.||.::..:|....::..|:.|.|:|.::.||...:|.  |.|||||
Human   228 WFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLT--HTDLKPE 290

  Fly   436 NILLCNP-----------------KRSAIKIVDFGSSCQLGQRIYHYIQSRFYRSPEVLLGIQYD 483
            |||....                 |.:.||:|||||:....:.....:.:|.||:|||:|.:.:.
Human   291 NILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWS 355

  Fly   484 LAIDMWSLGCILVEMHTGEPLFSGCNEVDQMNKIVEVLGMPPKYLLDQAHKTRKFF-------DK 541
            ...|:||:||||:|.:.|..:|...:..:.:..:..:||..|::::.:..| ||:|       |:
Human   356 QPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRK-RKYFHHNQLDWDE 419

  Fly   542 IVADGSYVLKKNQNGRKYKPPGSRKL-HDILGVETGGPGGRRLDEPGHSVSDYLKFKDLILRMLD 605
            ..:.|.||      .|:.||.....| ||                     .::.|..||:.|||:
Human   420 HSSAGRYV------RRRCKPLKEFMLCHD---------------------EEHEKLFDLVRRMLE 457

  Fly   606 FDPKTRVTPYYALQHNFF 623
            :||..|:|...||||.||
Human   458 YDPTQRITLDEALQHPFF 475

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mnb	NP_728107.2	PKc_DYRK1	289..628	CDD:271128	113/362 (31%)
		S_TKc	303..623	CDD:214567	108/345 (31%)
CLK4	NP_065717.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..46		1/5 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	102..143		7/47 (15%)
		PKc_CLK1_4	146..475	CDD:271115	111/358 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155026
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740