Protein Alignment mnb and hipk1b

DIOPT Version :10

• Sequence 1: NP_728107.2
• Gene: mnb / 32771
• FlyBaseID: FBgn0259168
• Length: 1047
• Species: Drosophila melanogaster
• Sequence 2: XP_009304049.2
• Gene: hipk1b / 572323
• ZFINID: ZDB-GENE-140324-1
• Length: 1126
• Species: Danio rerio
• Alignment Length: 1091
• Identity: 267/1091 - (24%)
• Similarity: 391/1091 - (35%)
• Gaps: 342/1091 - (31%)

  Fly   142 SSSSSSRMK----------AERALYYTMSAY----------GSSG-----GS-----VDAAQGSG 176
            |||:..|:|          |....|.::..|          |:||     ||     |.||..:|
Zfish    14 SSSAFCRVKKMKVESCAWDASNEAYSSVGQYSFNPAAGLSFGTSGLVFPPGSRGQVVVRAADSTG 78

  Fly   177 S---GGGRQRHAPLYGRFVDAEDLPATHRDVMHHHSSPSSSSEVRAMQARIPNHFREPASGP--- 235
            |   |..|:                 |..:..||..|.||......::.:  |...|.:.|.
Zfish    79 SLQRGSSRR-----------------TSHNNTHHSESHSSRGHRYGVKRK--NEEVESSGGGGSG 124

  Fly   236 ------LRKLSVDLIKTY-----KHINEVYYAKKKRRAQQTQGDDDSSNKKERKLYNDGYDDDNH 289
                  |.:||.....|.     .....:.::....::..:.|:.|             |....|
Zfish   125 SSSVQILEELSAPAFSTQTGGAGTTGQSIPHSAPTTKSSSSNGEGD-------------YQLVQH 176

  Fly   290 DYI--IKNGEKFLDRYEIDSLIGKGSFGQVVKAYDHEEQCHVAIKIIKNKKPFLNQAQIEVKLLE 352
            :.:  :.|.      ||:...:|:|:||||.|.:.......|||||:||...:..|.||||.:|
Zfish   177 EILCSVSNS------YEVLEFLGRGTFGQVAKCWKRGTNEIVAIKILKNHPSYARQGQIEVSIL- 234

  Fly   353 MMNRADAEN--KYYIVKLKRHFMWRNHLCLVFELLSYNLYDLLRNTNFRGVSLNLTRKFAQQLCT 415
              ||..|||  ::..|:....|..:.|.|||||:|..||||.|:::.|..:.|...|...||:.|
Zfish   235 --NRLSAENADEFNFVRSYECFQHKGHTCLVFEMLEQNLYDFLKHSKFSPLPLRHIRPILQQVAT 297

  Fly   416 ALLFLSTPELNIIHCDLKPENILLCNPKRS--AIKIVDFGSSCQLGQRIYH-YIQSRFYRSPEVL 477
            ||:.|..  |.:||.|||||||:|.:|.|.  .:|::||||:..:.:.:.. |:|||:||:||::
Zfish   298 ALMKLKC--LGLIHADLKPENIMLVDPIRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEII 360

  Fly   478 LGIQYDLAIDMWSLGCILVEMHTGEPLFSGCNEVDQMNKIVEVLGMPPKYLLDQAHKTRKFFDKI 542
            ||:.:..|||||||||::.|:..|.||:.|.:|.||:..|.:..|:||:|||....||.:||::
Zfish   361 LGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPPEYLLSAGTKTSRFFNR- 424

  Fly   543 VADGSYVL------KKNQNGRKYKPPGSRK-----LHDILGVETGGPGGRRLDEPGH-------- 588
            ..|.||.|      .::::....|...:||     |.|::.|..          |.|
Zfish   425 GPDSSYPLWRLKTPSEHESEMGIKSKEARKYIFNCLDDMMQVNL----------PNHLEGTDLLA 479

  Fly   589 SVSDYLKFKDLILRMLDFDPKTRVTPYYALQHNFFKRTADEATNTSGAGATANA----------- 642
            ..:|..:..||:.|||..|...|:||...|.|.|.  |.....|...:....:.
Zfish   480 EKADRRELIDLLKRMLRLDADKRITPTKTLAHPFV--TMSHLLNFPHSSHVKSCFQNMDICKRRN 542

  Fly   643 GAGGSGSSGAGGSSGGGVGGGLGASNSSS----GAVSSSSAAAP--------------------- 682
            .:..||.:....::..|..|.|..:.||.    ..|.|:..|.|
Zfish   543 SSFDSGKTLFAANTVPGTAGNLTVTFSSQLNQHSQVPSAGGAVPLLNYQPALYQQATINIPGLAQ 607

  Fly   683 ------TAAT----------------AAATAAG--SSGSGSSV-----GGGSSAAQQQQAMPLPL 718
                  |.:|                ...|..|  ||...||.     .|.....|.|.:.||.|
Zfish   608 PSIPLQTRSTQLCAQTEPFQQTLIVCPPTTIQGLPSSNKTSSYPVRMENGVPVVQQNQSSQPLQL 672

  Fly   719 -----------------------------PLPLPL------PPL---------AGPGGASD---- 735
                                         ||||.|      |.|         |.|.|...
Zfish   673 QPSMLTQGSCTPLMVATLHPHPAGVASQYPLPLALGCGAGRPALLEQTATVLQAWPAGTQQILIP 737

  Fly   736 ---GQCHGLLMHSVAANAMNNFSAL----------------SLQSNAHPPPSLANSH--HSTNSL 779
               .|..|:.:|:.:...:.|.|.|                :.||..|......|.|  ...|..
Zfish   738 SAWQQVPGMTIHNSSHQPVVNQSPLQALLSENSTQQTSSWRASQSGQHNGVVQQNPHILSGINPT 802

  Fly   780 GSLNHISPGSTGCHNNNS-----NSSNNNTRHSRLYG-------------SNMVNMVGHHNSGSS 826
            .|||..:..:|...|..|     .||::....|:.|.             |..|:::..|:....
Zfish   803 HSLNRGATTATRSQNKRSRICCDTSSSSALVASQSYSALLTQPIIISDTPSPAVSVITIHSDSED 867

  Fly   827 NNHNSISYPHAMECDPPQ--------------------MPPPPPNGHGRMR----------VPAI 861
            .:....   |...|.|..                    :.|.|.|||..::          |...
Zfish   868 EDERKF---HPASCGPSHRTNVISCLTVHDSDSSTASPLTPKPQNGHIGLQSSRLAKSLAVVAPT 929

  Fly   862 MQLQPNSYAPNSVPYYGNMSSSSVAAAAAAAAAAASHLMMTDSSVISASAAGGGQGGGNPGQNPV 926
            ::.||              ..||::|....|.....:..|....  :|:.......||:..::..
Zfish   930 VKTQP--------------VESSISAKIPPALGLPQNYYMKPKR--AAATRHQSSSGGSISEHQQ 978

  Fly   927 TPSAAAFLFPSQPAGTLYGTALGSLSDLPLPMPLPMSVPLQ----LPPSSS 973
            .||.      |||......|.  |.|..|.|..:|.|..|:    .||:||
Zfish   979 EPSR------SQPLNLSQTTV--SSSQAPPPGVIPSSSSLRRQHTYPPASS 1021

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mnb	NP_728107.2	PKc_DYRK1	289..628	CDD:271128	134/364 (37%)
hipk1b	XP_009304049.2	None