Protein Alignment mnb and hipk1a

DIOPT Version :9

• Sequence 1: NP_728107.2
• Gene: mnb / 32771
• FlyBaseID: FBgn0259168
• Length: 1047
• Species: Drosophila melanogaster
• Sequence 2: XP_021325698.1
• Gene: hipk1a / 572042
• ZFINID: ZDB-GENE-081031-101
• Length: 1125
• Species: Danio rerio
• Alignment Length: 1212
• Identity: 299/1212 - (24%)
• Similarity: 441/1212 - (36%)
• Gaps: 349/1212 - (28%)

  Fly    36 SFSSSIITSSSSS------LNHHPHNGHHNHHHPPHYINYLAQIGCQHRVRNWPTNGNQDQADDD 94
            :|||..::||..|      :.:|..|..:......:|         ||....  |||:.......
Zfish     7 AFSSPSVSSSGISRSKKLKVENHAWNVSNQSGESSYY---------QHSPSQ--TNGSSPSTSGF 60

  Fly    95 DAGHQIISKFLP---KSAWDTVLLDVKRDVDEDGDRDRDRVDGNVLMVQGSSSSSSRMKAERALY 156
            :..:...|...|   .|...||:    |..|..|....          ..||||||...:.|
Zfish    61 NPSYNSSSLVFPPPGASREQTVV----RAADSTGSGPE----------PSSSSSSSSTSSHR--- 108

  Fly   157 YTMSAYGSSGGSVDAAQGSGSGGGRQRHAPLYGRFVDAEDLPATHRDVMHHHSSPSSSSEVRAMQ 221
                       ..||...|.:..|.|:.|.|..:..:.:                 ||..|:.
Zfish   109 -----------GKDARSNSLTCEGYQKRASLKRKSEEVD-----------------SSDSVQI-- 143

  Fly   222 ARIPNHFREPASGPLRKLSVDLIKTYKHINEVYYAKKKRRAQQTQGDDDSSNKKERKLYNDG-YD 285
                          |.:||..::.     |.|........||...  ..:|..|....:::| |.
Zfish   144 --------------LEELSAPVLP-----NRVAGGGGNATAQSIA--HSTSTTKSSNSHSEGDYQ 187

  Fly   286 DDNHDYI--IKNGEKFLDRYEIDSLIGKGSFGQVVKAYDHEEQCHVAIKIIKNKKPFLNQAQIEV 348
            ...|:.:  :.|.      ||:...:|:|:||||.|.:.......|||||:||...:..|.||||
Zfish   188 LVQHEILCSVSNS------YEVLEFLGRGTFGQVAKCWKRGTNEIVAIKILKNHPSYARQGQIEV 246

  Fly   349 KLLEMMNRADAENKYYIVKLKRHFMWRNHLCLVFELLSYNLYDLLRNTNFRGVSLNLTRKFAQQL 413
            .:|..::..:|: ::..|:....|..:||.|||||:|..||||.|:::.|..:.|...|...||:
Zfish   247 SILSRLSTENAD-EFNFVRSYECFQHKNHTCLVFEMLEQNLYDFLKHSKFSPLLLKCIRPVLQQV 310

  Fly   414 CTALLFLSTPELNIIHCDLKPENILLCNPKRS--AIKIVDFGSSCQLGQRIYH-YIQSRFYRSPE 475
            .|||:.|.:  |.:||.|||||||:|.:|.|.  .:|::||||:..:.:.:.. |:|||:||:||
Zfish   311 STALMKLKS--LGLIHADLKPENIMLVDPIRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPE 373

  Fly   476 VLLGIQYDLAIDMWSLGCILVEMHTGEPLFSGCNEVDQMNKIVEVLGMPPKYLLDQAHKTRKFFD 540
            ::||:.:..|||||||||::.|:..|.||:.|.:|.||:..|.:..|:|.:|||....||.:||.
Zfish   374 IILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTSRFFH 438

  Fly   541 KIVADGSYVL--------------KKNQNGRKYKPPGSRKLHDILGVE-TGGPGGRRLDEPGHSV 590
            : ..|.||.|              .|::..|||.   ...|.|::.|. |...|...|.|.
Zfish   439 R-GPDSSYPLWRLKTPAEHEAEFGIKSKEARKYI---FNCLDDMMQVNMTNLEGTDILAEK---- 495

  Fly   591 SDYLKFKDLILRMLDFDPKTRVTPYYALQHNFFKRT---------------------------AD 628
            :|..:|.||:.:||..|...|:||...|.|.|...|                           .|
Zfish   496 ADRREFIDLLKKMLTLDADKRITPTKTLNHPFVTMTHLLHFPHSSHVKSCFQNMDICKRRCTAFD 560

  Fly   629 EATN--TSGAGATANAGAGGSGSSGAGGSSGGGVGGGLGASNSSS-------------------G 672
            ...|  :|..|.:|.|....:.||.....|.....||...|.||:                   |
Zfish   561 NNKNLFSSHNGPSAAANLTVTFSSQLNQHSQMASTGGQSLSLSSNVPLLNYQPGLYQQATINIPG 625

  Fly   673 AVSSS--SAAAPTAATA-----------------AATAAGSSGSGSSVGGGSS---AAQQQQAMP 715
            ....|  ..|.||...|                 |.....:..:|..|...:|   ..|.|...|
Zfish   626 LAQQSVPLQARPTQLCAQTEPFQQTLIVCPPTIQAGLQTSNKHTGYPVRMDNSVPIVPQNQSTQP 690

  Fly   716 L---------------------------PLPLPLPL-----------PPLAG-PGG-------AS 734
            |                           ||.|.|||           ..|.| |.|       :|
Zfish   691 LHIQPSMLTQFLHTSLYPFPNQSNSSSTPLTLRLPLTLSSRHLEQSATMLQGWPAGTQQILIPSS 755

  Fly   735 DGQCHGLLMHSVAANAMNNFSALS--LQSNAHPPPSLANSHHSTNSLGSLNHISPGSTGCHNNNS 797
            ..|..|:.||:.:...::..|.:|  |..|::...|....|.     |..:....||....|.|:
Zfish   756 WQQMSGMAMHNPSQPVLSTDSPMSSLLSDNSNQQNSWRGRHG-----GQCDGTQQGSVQGRNVNT 815

  Fly   798 NSSN----------NNTRHSRL-YGSNMVNMVGHHNSGSSNNHN------------------SIS 833
            .:|:          |..:.|:: :..|.|.........|:..|.                  ||.
Zfish   816 QASHAGAASARSQQNTLKRSKVRHADNRVRPTSSQQQASAAAHGCGDASQPIIISDTPSPAVSII 880

  Fly   834 YPHA--MECDPPQMPPPPPNGHGRMRVPAIMQL--QPNSYAPNSVP---------YYGNMSSSSV 885
            ..|:  .:.|..::||...:.:.|..|.:.:.:  ..:|.:..|.|         ...|..|.|:
Zfish   881 TIHSDTEDEDDRKIPPESCSVNQRTNVISCVTVHDSQDSDSSTSTPISPKRQSSFIENNTHSKSL 945

  Fly   886 AAAAAAAAA----AASHLMMTDSS------------------------VISASAAGGGQGG---G 919
            |....:...    |||....|:||                        .::.|.|....||   .
Zfish   946 AVVTPSVKTQLWDAASGEQSTNSSGKSKKGMASQSSDRHQRAASNRSQPLNLSQAQQSMGGPLRR 1010

  Fly   920 NPGQNPVTPSAA-----AFLFPSQPAGTLY----GTALGSLSDLPLPMPLPMSVPLQLPPSSSSS 975
            .|...|..||.:     |.||.|  |.:||    ..||.|:|         .:|. ||..|||:|
Zfish  1011 QPTYPPTGPSHSYRLHEASLFGS--ASSLYAYPASAALASVS---------QAVD-QLHNSSSTS 1063

  Fly   976 VSSGSASVGSGGVGVGV------VGQRRHITGPAAQVGISQS 1011
            .|..:.:.|.....:.:      :|...|.:.|..|...:||
Zfish  1064 SSRHTRTAGPYSASLSLLQKNSAMGVMCHASAPYQQQLSAQS 1105

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mnb	NP_728107.2	PKc_DYRK1	289..628	CDD:271128	133/385 (35%)
		S_TKc	303..623	CDD:214567	129/337 (38%)
hipk1a	XP_021325698.1	STKc_HIPK	201..528	CDD:271113	129/337 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590052
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R968
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.770