Protein Alignment mnb and hipk1a

DIOPT Version :10

• Sequence 1: NP_728107.2
• Gene: mnb / 32771
• FlyBaseID: FBgn0259168
• Length: 1047
• Species: Drosophila melanogaster
• Sequence 2: XP_009295328.2
• Gene: hipk1a / 572042
• ZFINID: ZDB-GENE-081031-101
• Length: 1124
• Species: Danio rerio
• Alignment Length: 1211
• Identity: 302/1211 - (24%)
• Similarity: 446/1211 - (36%)
• Gaps: 348/1211 - (28%)

  Fly    36 SFSSSIITSSSSS------LNHHPHNGHHNHHHPPHYINYLAQIGCQHRVRNWPTNGNQDQADDD 94
            :|||..::||..|      :.:|..|..:......:|         ||....  |||:.......
Zfish     7 AFSSPSVSSSGISRSKKLKVENHAWNVSNQSGESSYY---------QHSPSQ--TNGSSPSTSGF 60

  Fly    95 DAGHQIISKFLP---KSAWDTVLLDVKRDVDEDGDRDRDRVDGNVLMVQGSSSSSSRMKAERALY 156
            :..:...|...|   .|...||:    |..|..|.           :.:.||||||
Zfish    61 NPSYNSSSLVFPPPGASREQTVV----RAADSTGS-----------VPEPSSSSSS--------- 101

  Fly   157 YTMSAYGSSGGSVDAAQGSGSGGGRQRHAPLYGRFVDAEDLPATHRDVMHHHSSPSSSSEVRAMQ 221
               |:..|..|. ||...|.:..|.|:.|.|..:..:.:                 ||..|:.
Zfish   102 ---SSTSSHRGK-DARSNSLTCEGYQKRASLKRKSEEVD-----------------SSDSVQI-- 143

  Fly   222 ARIPNHFREPASGPLRKLSVDLIKTYKHINEVYYAKKKRRAQQTQGDDDSSNKKERKLYNDG-YD 285
                          |.:||..::.     |.|........||...  ..:|..|....:::| |.
Zfish   144 --------------LEELSAPVLP-----NRVAGGGGNATAQSIA--HSTSTTKSSNSHSEGDYQ 187

  Fly   286 DDNHDYI--IKNGEKFLDRYEIDSLIGKGSFGQVVKAYDHEEQCHVAIKIIKNKKPFLNQAQIEV 348
            ...|:.:  :.|.      ||:...:|:|:||||.|.:.......|||||:||...:..|.||||
Zfish   188 LVQHEILCSVSNS------YEVLEFLGRGTFGQVAKCWKRGTNEIVAIKILKNHPSYARQGQIEV 246

  Fly   349 KLLEMMNRADAENKYYIVKLKRHFMWRNHLCLVFELLSYNLYDLLRNTNFRGVSLNLTRKFAQQL 413
            .:|..::..:|: ::..|:....|..:||.|||||:|..||||.|:::.|..:.|...|...||:
Zfish   247 SILSRLSTENAD-EFNFVRSYECFQHKNHTCLVFEMLEQNLYDFLKHSKFSPLLLKCIRPVLQQV 310

  Fly   414 CTALLFLSTPELNIIHCDLKPENILLCNPKRS--AIKIVDFGSSCQLGQRIYH-YIQSRFYRSPE 475
            .|||:.|.:  |.:||.|||||||:|.:|.|.  .:|::||||:..:.:.:.. |:|||:||:||
Zfish   311 STALMKLKS--LGLIHADLKPENIMLVDPIRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPE 373

  Fly   476 VLLGIQYDLAIDMWSLGCILVEMHTGEPLFSGCNEVDQMNKIVEVLGMPPKYLLDQAHKTRKFFD 540
            ::||:.:..|||||||||::.|:..|.||:.|.:|.||:..|.:..|:|.:|||....||.:||.
Zfish   374 IILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTXGLPAEYLLSAGTKTSRFFH 438

  Fly   541 KIVADGSYVL--------------KKNQNGRKYKPPGSRKLHDILGVE-TGGPGGRRLDEPGHSV 590
            : ..|.||.|              .|::..|||.   ...|.|::.|. |...|...|.|.
Zfish   439 R-GPDSSYPLWRLKTPAEHEADFGIKSKEARKYI---FNCLDDMMQVNMTNLEGTDILAEK---- 495

  Fly   591 SDYLKFKDLILRMLDFDPKTRVTPYYALQHNFFKRT---------------------------AD 628
            :|..:|.||:.:||..|...|:||...|.|.|...|                           .|
Zfish   496 ADRREFIDLLKKMLTLDADKRITPTKTLNHPFVTMTHLLHFPHSSHVKSCFQNMDICKRRCTAFD 560

  Fly   629 EATN--TSGAGATANAGAGGSGSSGAGGSSGGGVGGGLGASNSSS-------------------G 672
            ...|  :|..|.:|.|....:.||.....|.....||...|.||:                   |
Zfish   561 NNKNLFSSHNGPSAAANLTVTFSSQLNQHSQMASTGGQSLSLSSNVPLLNYQPGLYQQATINIPG 625

  Fly   673 AVSSS--SAAAPTAATAAA------------TAAG----SSGSGSSVGGGSS---AAQQQQAMPL 716
            ....|  ..|.||...|..            |..|    :..:|..|...:|   ..|.|...||
Zfish   626 LAQQSVPLQARPTQLCAQTEPFQQTLIVCPPTIQGLQTTNKHTGYPVRMDNSVPIVPQNQSTQPL 690

  Fly   717 ---------------------------PLPLPLPL-----------PPLAG-PGG-------ASD 735
                                       ||.|.|||           ..|.| |.|       :|.
Zfish   691 HIQPSMLTQFLHTSLYPFPNQSNSSSTPLTLRLPLTLSSRHLEQSATMLQGWPAGTQQILIPSSW 755

  Fly   736 GQCHGLLMHSVAANAMNNFSALS--LQSNAHPPPSLANSHHSTNSLGSLNHISPGSTGCHNNNSN 798
            .|..|:.||:.:...::..|.:|  |..|::...|....|.     |..:....||....|.|:.
Zfish   756 QQMSGMAMHNPSQPVLSTDSPMSSLLSDNSNQQNSWRGRHG-----GQCDGTQQGSVQGRNVNTQ 815

  Fly   799 SSN----------NNTRHSRL-YGSNMVNMVGHHNSGSSNNHN------------------SISY 834
            :|:          |..:.|:: :..|.|.........|:..|.                  ||..
Zfish   816 ASHAGAASARSQQNTLKRSKVRHADNRVRPTSSQQQASAAAHGCGDASQPIIISDTPSPAVSIIT 880

  Fly   835 PHA--MECDPPQMPPPPPNGHGRMRVPAIMQL--QPNSYAPNSVP---------YYGNMSSSSVA 886
            .|:  .:.|..::||...:.:.|..|.:.:.:  ..:|.:..|.|         ...|..|.|:|
Zfish   881 IHSDTEDEDDRKIPPESCSVNQRTNVISCVTVHDSQDSDSSTSTPISPKRQSSFIENNTHSKSLA 945

  Fly   887 AAAAAAAA----AASHLMMTDSS------------------------VISASAAGGGQGG---GN 920
            ....:...    |||....|:||                        .::.|.|....||   ..
Zfish   946 VVTPSVKTQLWDAASGEQSTNSSGKSKKGMASQSSDRHQRAASNRSQPLNLSQAQQSMGGPLRRQ 1010

  Fly   921 PGQNPVTPSAA-----AFLFPSQPAGTLY----GTALGSLSDLPLPMPLPMSVPLQLPPSSSSSV 976
            |...|..||.:     |.||.|  |.:||    ..||.|:|         .:|. ||..|||:|.
Zfish  1011 PTYPPTGPSHSYRLHEASLFGS--ASSLYAYPASAALASVS---------QAVD-QLHNSSSTSS 1063

  Fly   977 SSGSASVGSGGVGVGV------VGQRRHITGPAAQVGISQS 1011
            |..:.:.|.....:.:      :|...|.:.|..|...:||
Zfish  1064 SRHTRTAGPYSASLSLLQKNSAMGVMCHASAPYQQQLSAQS 1104

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mnb	NP_728107.2	PKc_DYRK1	289..628	CDD:271128	133/385 (35%)
hipk1a	XP_009295328.2	None