DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment mnb and hipk3b

DIOPT Version :9

Sequence 1:NP_728107.2 Gene:mnb / 32771 FlyBaseID:FBgn0259168 Length:1047 Species:Drosophila melanogaster
Sequence 2:NP_001073628.1 Gene:hipk3b / 569156 ZFINID:ZDB-GENE-030131-82 Length:1261 Species:Danio rerio


Alignment Length:1173 Identity:277/1173 - (23%)
Similarity:420/1173 - (35%) Gaps:390/1173 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly    45 SSSSLNHHPHN-GHHNHHHPPHYIN-------YLAQIGCQ----------HRVRNWP-----TNG 86
            |...|...|.| .:|...:|..|:|       |..::...          ||.:::|     ..|
Zfish    22 SVKKLKVEPRNCVYHERAYPQTYLNGRTLGIAYPTKLTASFKTRDSVIGIHRGQDFPLQTAAVQG 86

  Fly    87 NQDQADDDDAGHQIISKFLPKSAWDTVLLDVKRDVD----EDGDRDRDRVDGNVLMVQGSSSSSS 147
            .:.|       |.|           ||....||...    |...:|:.||         .||.::
Zfish    87 VRRQ-------HTI-----------TVAQQQKRGASSQEKESEHQDKGRV---------CSSGAT 124

  Fly   148 RMKAE-RALYYTMSAYGSSG-GSVDAAQGSGSGGGRQRHAPLYGRFVDAEDLPATHR-------- 202
            |.... |.:.......|..| |.||.. |.|...|.|...   |.| |..|  ::||        
Zfish   125 RAAGRGRGVGSDSQEEGGGGQGGVDEG-GGGEDEGDQEDC---GGF-DLND--SSHRCGLKRKSG 182

  Fly   203 DVMHHHSSPSSSSEVRAMQARIPNHFREP--------ASGPLRKLSVDLIKTYKHINEVYYAKKK 259
            ::.:..|:.....::..:.|.:.::...|        ..||                      .|
Zfish   183 ELENLGSTMQIVEDLSMLPAMLQSNVGNPPVAVPQAVGGGP----------------------AK 225

  Fly   260 RRAQQTQGDDDSSNKKERKLYNDGYDDDNHDYI--IKNGEKFLDRYEIDSLIGKGSFGQVVKAYD 322
            :......||.|             |....|:.:  :||      .||:...:|:|:||||||.:.
Zfish   226 QGGGSGNGDGD-------------YQLVQHEMLCSLKN------TYEVLDFLGRGTFGQVVKCWK 271

  Fly   323 HEEQCHVAIKIIKNKKPFLNQAQIEVKLLEMMNRADAENKYYIVKLKRHFMWRNHLCLVFELLSY 387
            ...:..||:||:||...:..|.||||.:|..::..:|: ::.:|:....|..|:|.|||||:|..
Zfish   272 RGTKDIVAVKILKNHPSYARQGQIEVGILARLSNENAD-EHNLVRAFECFQHRSHTCLVFEMLEQ 335

  Fly   388 NLYDLLRNTNFRGVSLNLTRKFAQQLCTALLFLSTPELNIIHCDLKPENILLCNPKRS--AIKIV 450
            ||||.|:...|..:.|.:.|...||:.|||..|.  .:.:||.|||||||:|.:|.|.  .:|::
Zfish   336 NLYDFLKQNKFSPLPLKVIRPILQQVATALKKLK--GMGLIHADLKPENIMLVDPVRQPYRVKVI 398

  Fly   451 DFGSSCQLGQRIYH-YIQSRFYRSPEVLLGIQYDLAIDMWSLGCILVEMHTGEPLFSGCNEVDQM 514
            ||||:..:.:.:.. |:|||:||:||::||:.:..|||||||||::.|:..|.||:.|..|.||:
Zfish   399 DFGSASHVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGALEFDQI 463

  Fly   515 NKIVEVLGMPPKYLLDQAHKTRKFFDKIVADGSYV---LK-----------KNQNGRKYKPPGSR 565
            ..|.:..|:|.::||:...||.:||.: .:|..|.   ||           |::..|||      
Zfish   464 RYISQTQGLPGEHLLNVGTKTSRFFCR-ESDSPYATWRLKSTEEHETETGLKSKEARKY------ 521

  Fly   566 KLHDILGVETGGPGGRRLDEPGH--------------SVSDYLKFKDLILRMLDFDPKTRVTPYY 616
                |...         ||:..|              ...|..:|..|:.:||..|.:.|:.|..
Zfish   522 ----IFSC---------LDDIAHVNLVMNLEGCDLLAEKVDRAEFVALLKKMLLIDAEERIAPSD 573

  Fly   617 ALQHNF-----------------------------------------FKRTADE---ATN----- 632
            ||.|.|                                         |.||...   |:|     
Zfish   574 ALSHPFVTMQHLLDFPHSNHVKSCFHIMDVCCSRPGSYESHSRTKAQFVRTVPSTGAASNLTLPF 638

  Fly   633 --TSGAGATANAGAG----------GSGSSGAGGSSGGG-------VGGGLGASNSSSGAVSSSS 678
              .:|....|.|.:.          .:||:..|.|....       :.|.....|..:|...|..
Zfish   639 CKVTGIHTQALASSAPTVMHPGIPLQTGSAQFGDSFQQALILCPPTIQGLPPNPNKPAGYSVSME 703

  Fly   679 AAAPTAATAAATAAGSSGSG-SSVGGGSSAAQQ------QQAMPL----PLPLPLPLPPLAGPGG 732
            :..|....|:|........| .:..|.|:.|||      .|..|:    |....|...|:|||..
Zfish   704 STVPLVTQASAIQPLQIRPGVITQQGWSNRAQQILVPTWPQVTPVAPVAPSATTLASEPVAGPQR 768

  Fly   733 ASD-GQCHGLLMHSVAANAMNNFSALSLQSNAHPPPSLAN----SHHSTNSLGSLNHISPGSTGC 792
            .:| |:.|.   |.      |::|::.    .|..|.|.|    |.|...|:| :.|:.......
Zfish   769 LADWGKVHS---HG------NHYSSMM----PHHQPLLTNPMAMSAHQPISIG-IAHVVWPQPAA 819

  Fly   793 HNNNSNSSN--NNTRHSRLYGSNMVNMVGHHNSGSSNNHNSISYPHAMECDPPQMPPPPPNGHGR 855
            :..|..|||  ||..|                  |:|:.|       :.|..|:|.         
Zfish   820 NKRNKPSSNRCNNFMH------------------STNSQN-------VSCQSPKMV--------- 850

  Fly   856 MRVPAIMQLQPNSYAPNSVPYYGNMSSSSVAAAAAAAAAAASHLMMTDSSVISASAAGGGQGGGN 920
                                   |.:.::...||.....|.|..:..:.||...:         .
Zfish   851 -----------------------NSAKNTEEEAADCVVEAESEAVQEEESVCCKA---------E 883

  Fly   921 PGQNPVTPSAAAFLFPSQPAGTLYGTALGSLSDLPLPMPLPMSVPLQLPPSSSSSVSSGSASVGS 985
            |.....|.|       .:...|:.      ::|.|            .|..|..|:|||:...|.
Zfish   884 PEYEDPTVS-------QKQRQTIV------ITDSP------------SPAGSIISISSGTDEDGP 923

  Fly   986 GGVGVGVVGQRRHIT----GP---AAQVGISQ----SVGSGSSGSATGASSSDASSSSPMVGVCV 1039
                    ..::|..    .|   |.|..::.    |:.|..|..:|.:|:|:.||:||    |.
Zfish   924 --------DTQKHALECKGSPDCEACQSTLNMERVCSLSSPDSTLSTSSSASEQSSASP----CK 976

  Fly  1040 QQN 1042
            :.|
Zfish   977 RPN 979

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mnbNP_728107.2 PKc_DYRK1 289..628 CDD:271128 130/412 (32%)
S_TKc 303..623 CDD:214567 124/391 (32%)
hipk3bNP_001073628.1 STKc_HIPK3 251..580 CDD:271131 123/351 (35%)
S_TKc 252..580 CDD:214567 123/350 (35%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R968
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.940

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