Protein Alignment mnb and hipk3b

DIOPT Version :10

• Sequence 1: NP_728107.2
• Gene: mnb / 32771
• FlyBaseID: FBgn0259168
• Length: 1047
• Species: Drosophila melanogaster
• Sequence 2: NP_001073628.1
• Gene: hipk3b / 569156
• ZFINID: ZDB-GENE-030131-82
• Length: 1261
• Species: Danio rerio
• Alignment Length: 1173
• Identity: 277/1173 - (23%)
• Similarity: 420/1173 - (35%)
• Gaps: 390/1173 - (33%)

  Fly    45 SSSSLNHHPHN-GHHNHHHPPHYIN-------YLAQIGCQ----------HRVRNWP-----TNG 86
            |...|...|.| .:|...:|..|:|       |..::...          ||.:::|     ..|
Zfish    22 SVKKLKVEPRNCVYHERAYPQTYLNGRTLGIAYPTKLTASFKTRDSVIGIHRGQDFPLQTAAVQG 86

  Fly    87 NQDQADDDDAGHQIISKFLPKSAWDTVLLDVKRDVD----EDGDRDRDRVDGNVLMVQGSSSSSS 147
            .:.|       |.|           ||....||...    |...:|:.||         .||.::
Zfish    87 VRRQ-------HTI-----------TVAQQQKRGASSQEKESEHQDKGRV---------CSSGAT 124

  Fly   148 RMKAE-RALYYTMSAYGSSG-GSVDAAQGSGSGGGRQRHAPLYGRFVDAEDLPATHR-------- 202
            |.... |.:.......|..| |.||.. |.|...|.|...   |.| |..|  ::||
Zfish   125 RAAGRGRGVGSDSQEEGGGGQGGVDEG-GGGEDEGDQEDC---GGF-DLND--SSHRCGLKRKSG 182

  Fly   203 DVMHHHSSPSSSSEVRAMQARIPNHFREP--------ASGPLRKLSVDLIKTYKHINEVYYAKKK 259
            ::.:..|:.....::..:.|.:.::...|        ..||                      .|
Zfish   183 ELENLGSTMQIVEDLSMLPAMLQSNVGNPPVAVPQAVGGGP----------------------AK 225

  Fly   260 RRAQQTQGDDDSSNKKERKLYNDGYDDDNHDYI--IKNGEKFLDRYEIDSLIGKGSFGQVVKAYD 322
            :......||.|             |....|:.:  :||      .||:...:|:|:||||||.:.
Zfish   226 QGGGSGNGDGD-------------YQLVQHEMLCSLKN------TYEVLDFLGRGTFGQVVKCWK 271

  Fly   323 HEEQCHVAIKIIKNKKPFLNQAQIEVKLLEMMNRADAENKYYIVKLKRHFMWRNHLCLVFELLSY 387
            ...:..||:||:||...:..|.||||.:|..::..:|: ::.:|:....|..|:|.|||||:|..
Zfish   272 RGTKDIVAVKILKNHPSYARQGQIEVGILARLSNENAD-EHNLVRAFECFQHRSHTCLVFEMLEQ 335

  Fly   388 NLYDLLRNTNFRGVSLNLTRKFAQQLCTALLFLSTPELNIIHCDLKPENILLCNPKRS--AIKIV 450
            ||||.|:...|..:.|.:.|...||:.|||..|.  .:.:||.|||||||:|.:|.|.  .:|::
Zfish   336 NLYDFLKQNKFSPLPLKVIRPILQQVATALKKLK--GMGLIHADLKPENIMLVDPVRQPYRVKVI 398

  Fly   451 DFGSSCQLGQRIYH-YIQSRFYRSPEVLLGIQYDLAIDMWSLGCILVEMHTGEPLFSGCNEVDQM 514
            ||||:..:.:.:.. |:|||:||:||::||:.:..|||||||||::.|:..|.||:.|..|.||:
Zfish   399 DFGSASHVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGALEFDQI 463

  Fly   515 NKIVEVLGMPPKYLLDQAHKTRKFFDKIVADGSYV---LK-----------KNQNGRKYKPPGSR 565
            ..|.:..|:|.::||:...||.:||.: .:|..|.   ||           |::..|||
Zfish   464 RYISQTQGLPGEHLLNVGTKTSRFFCR-ESDSPYATWRLKSTEEHETETGLKSKEARKY------ 521

  Fly   566 KLHDILGVETGGPGGRRLDEPGH--------------SVSDYLKFKDLILRMLDFDPKTRVTPYY 616
                |...         ||:..|              ...|..:|..|:.:||..|.:.|:.|..
Zfish   522 ----IFSC---------LDDIAHVNLVMNLEGCDLLAEKVDRAEFVALLKKMLLIDAEERIAPSD 573

  Fly   617 ALQHNF-----------------------------------------FKRTADE---ATN----- 632
            ||.|.|                                         |.||...   |:|
Zfish   574 ALSHPFVTMQHLLDFPHSNHVKSCFHIMDVCCSRPGSYESHSRTKAQFVRTVPSTGAASNLTLPF 638

  Fly   633 --TSGAGATANAGAG----------GSGSSGAGGSSGGG-------VGGGLGASNSSSGAVSSSS 678
              .:|....|.|.:.          .:||:..|.|....       :.|.....|..:|...|..
Zfish   639 CKVTGIHTQALASSAPTVMHPGIPLQTGSAQFGDSFQQALILCPPTIQGLPPNPNKPAGYSVSME 703

  Fly   679 AAAPTAATAAATAAGSSGSG-SSVGGGSSAAQQ------QQAMPL----PLPLPLPLPPLAGPGG 732
            :..|....|:|........| .:..|.|:.|||      .|..|:    |....|...|:|||..
Zfish   704 STVPLVTQASAIQPLQIRPGVITQQGWSNRAQQILVPTWPQVTPVAPVAPSATTLASEPVAGPQR 768

  Fly   733 ASD-GQCHGLLMHSVAANAMNNFSALSLQSNAHPPPSLAN----SHHSTNSLGSLNHISPGSTGC 792
            .:| |:.|.   |.      |::|::.    .|..|.|.|    |.|...|:| :.|:.......
Zfish   769 LADWGKVHS---HG------NHYSSMM----PHHQPLLTNPMAMSAHQPISIG-IAHVVWPQPAA 819

  Fly   793 HNNNSNSSN--NNTRHSRLYGSNMVNMVGHHNSGSSNNHNSISYPHAMECDPPQMPPPPPNGHGR 855
            :..|..|||  ||..|                  |:|:.|       :.|..|:|.
Zfish   820 NKRNKPSSNRCNNFMH------------------STNSQN-------VSCQSPKMV--------- 850

  Fly   856 MRVPAIMQLQPNSYAPNSVPYYGNMSSSSVAAAAAAAAAAASHLMMTDSSVISASAAGGGQGGGN 920
                                   |.:.::...||.....|.|..:..:.||...:         .
Zfish   851 -----------------------NSAKNTEEEAADCVVEAESEAVQEEESVCCKA---------E 883

  Fly   921 PGQNPVTPSAAAFLFPSQPAGTLYGTALGSLSDLPLPMPLPMSVPLQLPPSSSSSVSSGSASVGS 985
            |.....|.|       .:...|:.      ::|.|            .|..|..|:|||:...|.
Zfish   884 PEYEDPTVS-------QKQRQTIV------ITDSP------------SPAGSIISISSGTDEDGP 923

  Fly   986 GGVGVGVVGQRRHIT----GP---AAQVGISQ----SVGSGSSGSATGASSSDASSSSPMVGVCV 1039
                    ..::|..    .|   |.|..::.    |:.|..|..:|.:|:|:.||:||    |.
Zfish   924 --------DTQKHALECKGSPDCEACQSTLNMERVCSLSSPDSTLSTSSSASEQSSASP----CK 976

  Fly  1040 QQN 1042
            :.|
Zfish   977 RPN 979

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mnb	NP_728107.2	PKc_DYRK1	289..628	CDD:271128	130/412 (32%)
hipk3b	NP_001073628.1	STKc_HIPK3	251..580	CDD:271131	123/351 (35%)