Protein Alignment mnb and dyrk4

DIOPT Version :10

• Sequence 1: NP_728107.2
• Gene: mnb / 32771
• FlyBaseID: FBgn0259168
• Length: 1047
• Species: Drosophila melanogaster
• Sequence 2: XP_009296230.2
• Gene: dyrk4 / 564976
• ZFINID: ZDB-GENE-091015-3
• Length: 644
• Species: Danio rerio
• Alignment Length: 628
• Identity: 215/628 - (34%)
• Similarity: 307/628 - (48%)
• Gaps: 137/628 - (21%)

  Fly   174 GSGSGGGRQRHAPLYGRFVDAEDLPATHRDVMHHHSS-PSSSSE-VRAMQA--------RIPNHF 228
            |:|.|...|..||:       :.:..|:..::|.:.: ||...: |::.|.        :.||.|
Zfish    65 GTGVGTLPQLEAPV-------KQVLVTNGKLLHSNGTLPSIVKQLVQSTQGNQEERPRPQFPNRF 122

  Fly   229 REPASGPLRKLSVDL----------IKTY-------------KHI---------------NEVYY 255
                ...:..||..|          |:||             ||.               :|::|
Zfish   123 ----GSSVENLSESLTRSIINKFEKIRTYEGQRLPMSPTTALKHFQNQLTEYEREEIMDYSEIWY 183

  Fly   256 -AKKKRRAQQTQGDDDSSNKKERKLYNDGYDDDNHDYIIKNGEKFLDRYEIDSLIGKGSFGQVVK 319
             ....::.:.:||...          |.||||::..|:....:....|||:..:|||||||||:|
Zfish   184 LGLDTKKIEGSQGSPQ----------NAGYDDEHGSYLKVLHDHIGYRYEVLEVIGKGSFGQVLK 238

  Fly   320 AYDHEEQCHVAIKIIKNKKPFLNQAQIEVKLLEMMNRADAENKYYIVKLKRHFMWRNHLCLVFEL 384
            ..||:....||||||:|||.|.:||.:|:|:|:.:.|.|.:|.:.::.:|.:|.:|||||:.|||
Zfish   239 CLDHKTNETVAIKIIRNKKRFHHQALVELKILDAVRRRDRDNCHNVIHMKEYFYFRNHLCISFEL 303

  Fly   385 LSYNLYDLLRNTNFRGVSLNLTRKFAQQLCTALLFLSTPELNIIHCDLKPENILLCNPKRSAIKI 449
            |..|||:|::..||:|.||.|.|:||..|...|..|...:  |||||||||||||....:..||:
Zfish   304 LGANLYELIKKNNFQGFSLGLIRRFAHSLLKCLQMLHKEK--IIHCDLKPENILLSQRGQGNIKV 366

  Fly   450 VDFGSSCQLGQRIYHYIQSRFYRSPEVLLGIQYDLAIDMWSLGCILVEMHTGEPLFSGCNEVDQM 514
            |||||||...||:|.||||||||||||:||..|.:|||||||||||.|::||.|||.|.:||:|:
Zfish   367 VDFGSSCYEQQRVYTYIQSRFYRSPEVILGHPYSMAIDMWSLGCILAELYTGYPLFPGESEVEQI 431

  Fly   515 NKIVEVLGMPPKYLLDQAHKTRKFFDKIVADGSYVLKKNQNGRKYKPPGSRKLHDILGVETGGPG 579
            ..|:|::|:||...:..|.:.|.|||   :.|:.....|..|:|:: |.|:.|..:|  :|..|
Zfish   432 ACIMEIMGLPPNDFVQTASRRRLFFD---SKGNPRNITNSKGKKHR-PSSKDLASVL--KTNDP- 489

  Fly   580 GRRLDEPGHSVSDYLKFKDLILRMLDFDPKTRVTPYYALQHNF---------------FKRTADE 629
                           .|.|.|.|.|.:||..|:||..|:||.:               .::.:|.
Zfish   490 ---------------LFLDFIQRCLVWDPTKRMTPDEAMQHEWITEGRLNRLHPKPRPLRKESDN 539

  Fly   630 ATNTSGAGATANAGAGGSGS-------SGAGGSSGGGVG----GGLGASNSSSGAVSSSSAAAPT 683
            ....:...||.|..|..|||       |.|....|..|.    ..:|||.....:.:||.:.:..
Zfish   540 NYEFTYRKATGNRTADKSGSDEKLKRVSDASSKGGKTVSEERLRPIGASAEEENSENSSKSLSKD 604

  Fly   684 AATAAATAAGSSG-----------SGSSVGGGSSAAQQQQAMP 715
            :.|      .|||           :|||....||...:.|.:|
Zfish   605 SKT------DSSGERSVQIIIKPQTGSSSDSSSSEGPEPQFLP 641

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mnb	NP_728107.2	PKc_DYRK1	289..628	CDD:271128	155/353 (44%)
dyrk4	XP_009296230.2	None