DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mnb and hipk3a

DIOPT Version :9

Sequence 1:	NP_728107.2	Gene:	mnb / 32771	FlyBaseID:	FBgn0259168	Length:	1047	Species:	Drosophila melanogaster
Sequence 2:	XP_021326178.1	Gene:	hipk3a / 564413	ZFINID:	ZDB-GENE-061207-54	Length:	1276	Species:	Danio rerio

Alignment Length:	1026	Identity:	248/1026 - (24%)
Similarity:	368/1026 - (35%)	Gaps:	304/1026 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   138 MVQGSSSSSSRMKAERAL-YYTMSAYG---SSGGSVDAAQGSG-SGGGRQRHAPLYGRFVDAEDL 197
            :::.:||..:|:.:|..| |::.:..|   .||.|...:|||. |.||    ||        |.:
Zfish    86 LLRRASSPYNRVASEGKLQYFSKAEVGVEEKSGDSGQNSQGSSRSSGG----AP--------EGV 138

  Fly   198 PATHRDVMHHHSSPSSSSE----------------VRAMQARIPNHFREPASGPLRKLSVDLIKT 246
            ....|      |...:|.|                .:::...:..|...||..|....|.
Zfish   139 RRKER------SGGLNSDEGTQKCGFKCKGQEIENSKSIMQIVEEHSTLPAMLPTNVGST----- 192

  Fly   247 YKHINEVYYAKKKRRAQQT-----QGDDDSSNKKERKLYNDGYDDDNHDYIIKNGEKFLDRYEID 306
                ..|..|..:::...|     .||.|             |....|:.:.    .....||:.
Zfish   193 ----TAVGVAPPEQKGTGTGAVNGTGDGD-------------YQLVQHEVLC----SMKHTYEVL 236

  Fly   307 SLIGKGSFGQVVKAYDHEEQCHVAIKIIKNKKPFLNQAQIEVKLLEMMNRADAENKYYIVKLKRH 371
            ..:|:|:||||||.:.......||:||:||...:..|.||||.:|..::..:|| ::.:|:....
Zfish   237 EFLGRGTFGQVVKCWKRGTNEIVAVKILKNHPSYARQGQIEVSILARLSGENAE-EHNLVRAFEC 300

  Fly   372 FMWRNHLCLVFELLSYNLYDLLRNTNFRGVSLNLTRKFAQQLCTALLFLSTPELNIIHCDLKPEN 436
            |..|:|.|||||:|..||||.|:...|..:.|.:.|...||:.|||..|.:  |.:||.||||||
Zfish   301 FQHRSHTCLVFEMLEQNLYDFLKQNKFSPLPLKVIRPVLQQVATALKKLKS--LGLIHADLKPEN 363

  Fly   437 ILLCNPKRS--AIKIVDFGSSCQLGQRIYH-YIQSRFYRSPEVLLGIQYDLAIDMWSLGCILVEM 498
            |:|.:|.|.  .:|::||||:..:.:.:.. |:|||:||:||::||:.:..|||||||||::.|:
Zfish   364 IMLVDPVRQPFRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAEL 428

  Fly   499 HTGEPLFSGCNEVDQMNKIVEVLGMPPKYLLDQAHKTRKFFDKIVADGSYV---LK--------- 551
            ..|.||:.|..|.||:..|.:..|:|.:.||:...||.:||.| .:|..|.   ||
Zfish   429 FLGWPLYPGALEYDQIRYISQTQGLPGEQLLNVGTKTARFFCK-ESDSPYTAWRLKTTEEHEAET 492

  Fly   552 --KNQNGRKYKPPGSRKLHDILGVETGGPGGRRLDEPGH--------------SVSDYLKFKDLI 600
              |::..|||          |...         ||:.||              ..:|..:|.||:
Zfish   493 GLKSKEARKY----------IFSC---------LDDIGHVNLMLNMEGCDQLAEKADRREFVDLL 538

  Fly   601 LRMLDFDPKTRVTPYYALQHNFFK-------------------------RTA------------- 627
            ..||..|...|:.|..||.|.|..                         ||:
Zfish   539 KMMLMIDADQRIAPSDALTHPFVTMQHLMDFPHCNHVQSCFHIMDVCHLRTSIFDTLNRNKAPPL 603

  Fly   628 -DEATNTSGAGATANAGAGGSGSSGAGGSSGGGVGGGLGASNSSSGAVSSSSAAAPTAATAAATA 691
             ...|..|....|.                         |.|...   |..|...|.:|......
Zfish   604 MKPVTLPSAPNITV-------------------------AFNKMP---SVHSQTLPPSAPPVVHP 640

  Fly   692 AGSSGSGSSVGGGSSAAQQ--------------------------QQAMPL----PLPLPLPLPP 726
            .....:||:..|.:.:.||                          :..:||    |...|||:.|
Zfish   641 GIPIQTGSAQFGCNESFQQALILCPPAMQGIPSNPNQPAGYSVRMENTIPLVTQAPAIQPLPMRP 705

  Fly   727 LAGPGGASDGQCHGLLMHSVAANAMNNFSALSLQSNAHPPPSLANSHHSTNSLGSLNHISPGSTG 791
                         |::.....:|........:.|.  .|||  |.|..|...:|:......|:||
Zfish   706 -------------GVIAQQPWSNRTPQILVPAWQQ--VPPP--ATSLASDTVVGAQRRGDWGTTG 753

  Fly   792 --------------CHNNNSNSSNNNTRHSRLYGSNMVNMVGHH--NSG---------SSNNHNS 831
                          |.....:||:.::...:....|.:.:..|.  |.|         :||..|.
Zfish   754 TTAFPCLVLETKQMCWKVRPHSSHYSSVMPQPIVPNQMAVSAHQPINIGIAHVVWPQPASNKRNK 818

  Fly   832 ISYPHAME-----------CDPPQMPP-----PPPNGHGRMRVPAIMQLQP------NSYAPNSV 874
            .|...:|.           |..|:||.     .|........|.|.::.:|      .|....:|
Zfish   819 PSQNRSMNVSHFTDTQPSVCPSPKMPEMLPSVEPQTSSPERAVQAQVKQEPKQTEEEESCCKTTV 883

  Fly   875 PYYGNMSSSS--VAAAAAAAAAAASHLMMTDSSVISASAAGGGQGGGNPGQNPVTPS--AAAFLF 935
            |   |....|  :..:.:.|.:..|....||.....|......:..|:|.....|.|  ......
Zfish   884 P---NKQRESIIIRESPSPAVSVISISSGTDEEEEQAQRCSLNKCKGSPECEACTGSLNMERVCS 945

  Fly   936 PSQPAGTLYGTALGSLSDLPLPMPLPMSVPLQ------------LPPSSSS 974
            .|.|..:|..::..|....|.|...|.|:...            .|||.||
Zfish   946 LSSPDSSLSTSSSASAQSSPSPCKRPSSISEDDGHESGCETVDGSPPSDSS 996

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mnb	NP_728107.2	PKc_DYRK1	289..628	CDD:271128	132/408 (32%)
mnb	NP_728107.2	S_TKc	303..623	CDD:214567	128/350 (37%)
hipk3a	XP_021326178.1	PKc_like	232..561	CDD:328722	128/351 (36%)
		NUT	601..>737	CDD:315542	29/180 (16%)
		Atrophin-1	<970..1274	CDD:331285	7/27 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810