DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mnb and clk2a

DIOPT Version :9

Sequence 1:	NP_728107.2	Gene:	mnb / 32771	FlyBaseID:	FBgn0259168	Length:	1047	Species:	Drosophila melanogaster
Sequence 2:	NP_001038344.1	Gene:	clk2a / 558981	ZFINID:	ZDB-GENE-030131-298	Length:	526	Species:	Danio rerio

Alignment Length:	561	Identity:	156/561 - (27%)
Similarity:	249/561 - (44%)	Gaps:	100/561 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   122 DEDGDRDRDRVDGNVLMVQGS---SSSSSRMKAERALYYTMSAYGSSGGSVDAAQGSGSGGGRQR 183
            |...:|||||..|.....:.|   ||||.|.:..|       .:....|...:.........|:.
Zfish    20 DRYRERDRDRDRGRKPRHRRSPTYSSSSERERRAR-------GHRQDTGYARSRSYDNRSSDRRP 77

  Fly   184 HAPLYGRFVDAEDLPATH-----RDVMHHHSSPSSSSEVRAMQARIPNHFREPASGPLRKLSVDL 243
            :...||......|    |     ||....|.:||             |::...||.     |.|.
Zfish    78 YDRHYGESYRRLD----HSRERDRDQNRDHRTPS-------------NYYSRDASP-----SYDF 120

  Fly   244 IKTYKHINEVYYAKK------KRRAQQTQGDDDSSNKKE---RKLYNDGYDDDNHDYIIKNGEKF 299
            .:......|..|.:|      |||.::|:....||::.:   |.|.  ..||:....|.::|:..
Zfish   121 RRGRDRDREDSYRRKGSRRKHKRRRRRTRSYSASSSRSDSGTRALC--VRDDEEGHLICRSGDVL 183

  Fly   300 LDRYEIDSLIGKGSFGQVVKAYDHEE-QCHVAIKIIKNKKPFLNQAQIEVKLLEMMNRADAENKY 363
            .:||||.|.:|:|:||:|::..||.. ..|||:|||||.:.:...|::|:.:||.:|..|.||..
Zfish   184 QERYEIVSTLGEGTFGRVMQCIDHRRGGAHVALKIIKNVEKYKEAARLEINVLERINEKDPENNN 248

  Fly   364 YIVKLKRHFMWRNHLCLVFELLSYNLYDLLRNTNFRGVSLNLTRKFAQQLCTALLFLSTPELNII 428
            ..|::...|.:..|:|:.||||:.:.:|.|:..|:...|:|..|..|.|:|.|:.||.  |..:.
Zfish   249 LCVQMFDWFDYHGHMCISFELLALSTFDFLKENNYLPYSINQVRHMAYQVCLAVKFLH--ENKLT 311

  Fly   429 HCDLKPENILLCNP-----------------KRSAIKIVDFGSSCQLGQRIYHYIQSRFYRSPEV 476
            |.||||||||..|.                 |.:|:::|||||:....:.....:.:|.||:|||
Zfish   312 HTDLKPENILFVNSDYTVTYNVEKKRDERTVKNTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEV 376

  Fly   477 LLGIQYDLAIDMWSLGCILVEMHTGEPLFSGCNEVDQMNKIVEVLGMPPKYLLDQAHKTRKFF-- 539
            :|.:.:....|:||:|.||.|.:.|..||...:..:.:..:..:||..|..::.:..|.:.|:
Zfish   377 ILELGWSQPCDVWSIGSILFEYYLGFTLFQTHDNREHLAMMERILGPVPSRMIRKTRKQKYFYRG 441

  Fly   540 ----DKIVADGSYVLKKNQNGRKYKPPGSRKLHDILGVETGGPGGRRLDEPGHSVSDYLKFKDLI 600
                |:..:.|.||.:..:..|:|....:.:.|.:.                          |||
Zfish   442 RLDWDENSSAGRYVRENCKPLRRYLLSEAEEHHQLF--------------------------DLI 480

  Fly   601 LRMLDFDPKTRVTPYYALQHNFFKRTADEATNTSGAGATAN 641
            ..||:::|..|:|...||:|.||:.....:..::|....||
Zfish   481 EAMLEYEPSKRLTLAAALRHPFFQSGISSSELSAGKSWEAN 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mnb	NP_728107.2	PKc_DYRK1	289..628	CDD:271128	110/362 (30%)
mnb	NP_728107.2	S_TKc	303..623	CDD:214567	105/343 (31%)
clk2a	NP_001038344.1	DUF1777	34..>117	CDD:285811	21/111 (19%)
		PRP38_assoc	<37..104	CDD:289628	15/77 (19%)
		PKc_CLK2	174..503	CDD:271117	108/356 (30%)
		S_TKc	187..503	CDD:214567	105/343 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910